3.7. La lettura delle necropoli nel panorama delle ricerche italiane
3.7.3. La compresenza di più ideologie e le diverse sfere d'azione
Several different terms are often used to describe joint disorders that result in joint pain. Arthralgia means joint pain. Arthritis implies the presence of an inflam-matory component to the disorder. Arthropathy is a general term meaning joint disease, but it usually means that there is some degree of cartilage damage. Rheu-matologic disease (e.g., rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis), infection, and crystal deposition are examples of conditions that pro-duce an inflammatory response and a resultant loss of cartilage. Osteoarthritis, or degenerative joint disease, occurs primarily as a result of cartilage break-down, but it often has a component of secondary inflammation. This chapter focuses on arthritis; however, some of the medications and conditions listed in the following may cause arthralgia without an inflammatory process.
Before attributing a patient’s pain to arthritis, the physician must consider other potential causes of pain. These potential diagnoses include intra-articular processes that are distinct from arthritis (impingement, neoplasm) and periarticular sources of pain (bursitis, tendonitis). Patients may also have referred pain from an adjacent site or a distant site, which occurs with radiculopathy and spinal stenosis.
The 2010 American College of Rheumatology and European League Against Rheumatism classification criteria for rheumatoid arthritis provides a tool to diagnose rheumatoid arthritis earlier and distinguish it from other types of inflammatory synovitis. The 2010 criteria (Table 5-1) differ from the 1987 cri-teria because the new cricri-teria no longer include the presence of rheumatoid nodules or radiographic erosive changes, which are less likely in early rheuma-toid arthritis. Symmetric arthritis is also not included in the 2010 criteria.
Criteria Score
Target population (who should be tested?): patients who:
1) have at least one joint with definite clinical synovitis (swelling)*
2) with the synovitis not better explained by another disease†
Classification criteria for RA (score-based algorithm: add score of categories A through D; a score of6 of 10 is needed for classification of a patient as having definite RA){ A. Joint involvement§
One large jointjj 0
Two to 10 large joints 1
One to three small joints (with or without involvement of large joints)¶ 2 Four to 10 small joints (with or without involvement of large joints) 3
>10 joints (at least one small joint)# 5
B. Serology (at least one test result is needed for classification)**
Negative RF and negative ACPA 0
Low-positive RF or low-positive ACPA 2
High-positive RF or high-positive ACPA 3
Table 5-1. The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis—cont'd
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Criteria Score C. Acute phase reactants (at least one test result is needed for classification)††
Normal CRP and normal ESR 0
Abnormal CRP or normal ESR 1
D. Duration of symptoms{{
<6 wks 0
6 wks 1
ACPA, Anticitrullinated protein antibody; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate;RA, rheumatoid arthritis.
*The criteria are aimed at classification of newly presenting patients. In addition, patients with erosive disease typical of RA with a history compatible with previous fulfillment of the 2010 criteria should be classified as having RA. Patients with chronic disease, including those whose disease is inactive (with or without treatment), who, based on retrospectively available data, have previously fulfilled the 2010 criteria should be classified as having RA.
†Differential diagnoses differ in patients with different presentations, but may include conditions such as systemic lupus erythematosus, psoriatic arthritis, and gout. If it is unclear about the relevant differential diagnoses to consider, an expert rheumatologist should be consulted.
{Although patients with a score of less than 6 of 10 are not classifiable as having RA, their status can be reassessed, and the criteria might be fulfilled cumulatively over time.
§Joint involvement refers to any swollen or tender joint on examination, which may be confirmed by imaging evidence of synovitis. Distal interphalangeal joints, first carpometacarpal joints, and first metatarsophalangeal joints are excluded from assessment. Categories of joint distribution are classified according to the location and number of involved joints, with placement into the highest category possible based on the pattern of joint involvement.
jj“Large joints” refers to shoulders, elbows, hips, knees, and ankles.
¶“Small joints” refers to the metacarpophalangeal joints, proximal interphalangeal joints, second to fifth metatarsophalangeal joints, thumb interphalangeal joints, and wrists.
#In this category, at least one of the involved joints must be a small joint; the other joints can include any combination of large and additional small joints, as well as other joints not specifically listed elsewhere (e.g., temporomandibular, acromioclavicular, sternoclavicular).
**Negative refers to international unit values that are less than or equal to the upper limit of normal for the laboratory and assay; low positive refers to international unit values that are higher than the upper limit of normal but three or less times the upper limit of normal for the laboratory and assay; high positive refers to international unit values that are more than three times the upper limit of normal for the laboratory and assay. When rheumatoid factor information is only available as positive or negative, a positive result should be scored as low positive for the rheumatoid factor.
††Normal and/or abnormal is determined by local laboratory standards.
{{Duration of symptoms refers to patient self-report of the duration of signs or symptoms of synovitis (e.g., pain, swelling, tenderness) of joints that are clinically involved at the time of assessment, regardless of treatment status.
Adapted with permission from Aletaha D, Neogi T, Silman AJ, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010;69:1583 [published correction appears in Ann Rheum Dis. 2010;69:1892].
Table 5-1. The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis
Chapter 5 ARTHRITIS AND ARTHRALGIA
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Medications Associated with Arthritis/Arthralgia
Bacillus Calmette-Guerin (BCG) Carbamazepine
Granulocyte colony-stimulating factor Gold salts
Griseofulvin Hydralazine Infliximab Interferons
Interleukin-2 and interleukin-6 Isoniazid
Chapter 5 ARTHRITIS AND ARTHRALGIA
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Simvastatin Steroids (systemic) Sulfasalazine Tacrolimus Tamoxifen Terbinafine Tetracycline Ticlopidine Vitamin A excess
Causes of Arthritis Ankylosing spondylitis
Degenerative joint disease (osteoarthritis) Giant cell arteritis
Gout
Hemochromatosis Hemophilia Infection
• Atypical mycobacteria
• Bacterial (Staphylococcus aureus, Streptococcus, Salmonella, Neisseria gonorrhoeae, Haemophilus influenzae, Escherichia coli, Pseudomonas)
• Fungi (Coccidioides immitis, Histoplasma capsulatum, Blastomyces dermatitidis)
• Gonorrhea
• HIV arthritis
• Lyme disease
• Tuberculosis
• Viral (HIV, hepatitis B, hepatitis C, parvovirus B19, rubella, coxackieviruses, alphaviruses, Human T-Lymphocytic Virus [HTLV]-1) Immune reconstitution syndrome following highly active antiretroviral
therapy Infectious endocarditis Inflammatory bowel disease Medications
Polymyalgia rheumatica
Pseudogout (calcium pyrophosphate dehydrate crystal deposition disease) Psoriatic arthritis
Reactive arthritis (immunologic reaction to a previous infection) Referred pain or pain from intra-articular disease other than arthritis
• Bursitis
• Impingement syndromes
• Neoplasm
• Spinal stenosis
• Radiculopathy
• Tendinitis
Chapter 5 ARTHRITIS AND ARTHRALGIA
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Rheumatoid arthritis Scleroderma
Seronegative spondyloarthropathies Sickle cell anemia
Still disease
Systemic lupus erythematosus Trauma
Whipple disease
Key Historical Features
✓ Distribution/location of pain
✓ Quantification of pain
✓ Description of pain
✓ Radiation
✓ Duration and timing of symptoms
✓ Swelling
✓ Morning stiffness
✓ Degree of functional impairment
✓ Pain that wakes the patient
✓ Effect of treatment modalities
✓ Mechanical symptoms, such as catching, locking, or joint instability
✓ Systemic symptoms, such as fever, weight loss, night sweats, or fatigue
✓ Medical history, especially previous trauma to the affected joint
✓ Surgical history, especially surgery on the affected joint
✓ Medications
✓ Family history of arthritis or rheumatologic disease
✓ Social history, including smoking, alcohol use, illicit drug use
✓ Occupational history, especially jobs associated with repetitive trauma
✓ Review of systems for constitutional symptoms, urethritis, conjunctivitis, or skin lesions
Key Physical Findings
✓ Inspection
• Posture
• Body habitus
• Use of mobility aids
• Gait
• Leg length discrepancy
• Scars from previous trauma or surgery
• Swelling
• Erythema
• Muscle atrophy
• Deformity of shape or alignment
• Skin lesions
Chapter 5 ARTHRITIS AND ARTHRALGIA
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✓ Palpation
• Warmth
• Effusion
• Tenderness to palpation over individual structures
✓ Range of motion
• Active and passive range of motion testing
• Presence of crepitus
✓ Muscle testing
✓ Ligament testing for laxity and joint instability