CONSIDERACIONES SOBRE CAPACIDAD DE LAS LÍNEAS DE TRANSMISIÓN .1 SUSTENTO DEL PETITORIO

In the current study mouse pups were dosed orally with concentrations of genistein that produced biologically relevant serum concentrations, BPA at the reproductive NOAEL identified by Tyl et al. (2002; 2008), or with a combination of genistein and BPA. These compounds were administered by a method that takes

advantage of the natural suckling ability of the pup. The model used in the current study more adequately mimics human infant exposure. Direct administration of the compound to the pup allows for first-pass metabolism, which is essential for understanding the effects of these compounds on the body.

The results from the current study indicate that genistein, at physiological concentrations, and BPA at the NOAEL or below, do not adversely affect several key endpoints in male reproductive tract development and function. In fact BPA may have a stimulatory affect on male spermatogenesis (Table 2). It is likely that exposure to these two xenoestrogens has not resulted in the decline in sperm numbers that has been seen over the latter half of the twentieth century. The current study also shows that doses of BPA below the NOAEL identified by Tyl et al. (2002; 2008) are capable of causing an effect when administered in combination with physiological concentrations of genistein. However, in agreement with Tyl et al. (2002; 2008) these effects are not necessarily adverse. Investigation of BPA and genistein’s combined effects on other body organs needs to be completed. Results from these studies will paint a complete picture of the combined effects of these endocrine disruptors. Future studies should aim at using concentrations of BPA that mimic human infant serum levels. Results from these studies

will be better able to answer the questions regarding the safety of using plastic baby bottles. Animals in this study were only observed till 4 months of age, and it is possible that testicular tumors/cancer may become evident at 12 months of age or greater. Therefore, longer term studies on these animals may be necessary to identify the full effect of these endocrine disruptors. More mechanistic studies should also be conducted to help identify the cause of the effects seen. Sertoli cell numbers, testosterone, and FSH concentrations should also be measured. Results from the current study indicate that consumption of soy infant formula from plastic baby bottles is not detrimental to the development of the male reproductive tract. It is the conclusion of this author based on these results, that it is safe for parents to use plastic baby bottles when administering soy infant formula.

Table 2: Summary table describing the results from treatment with 50 mg/kg/d Genistein, or 50 mg/kg/d BPA, or 50 mg/kg/d genistein and 50 mg/kg/d BPA (Gen/BPA50), or 50 mg/kg/d genistein and 5 mg/kg/d BPA (Gen/BPA5), or 50 mg/kg/d genistein and 0.5 mg/kg/d BPA (Gen/BPA0.5). Arrow indicates an up regulation of the measured parameter. Dashes indicate no effect of treatment on the measured parameter.

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