PILAR IV: APRENDER A SER
5.2 CONTRIBUCIÓN DEL MODELO
While this thesis has advanced the understanding of the long-lasting consequences of early-life seizures on GABA-A receptors, the mechanisms whereby kainic acid –induced seizures may change GABA-Aergic synaptic transmission in immature brain are unclear. In addition, it will be interesting to study the changes in GABA-A subunits differences between seizure-treated and control rats in future. Furthermore, behavioral studies can be helpful to make better understanding of long-lasting effect of early-life seizures on memory and learning.
54
References
Abou‐Khalil, B., Andermann, E., Andermann, F., Olivier, A., Quesney, L. F. (1993). Temporal
lobe epilepsy after prolonged febrile convulsions: Excellent outcome after surgical treatment. Epilepsia, 34(5), 878-883.
Aggleton, John P., and Malcolm W. Brown. (1999). Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behavioral and Brain Sciences 22(3), 425-444. Alger, B., Nicoll, R. (1982). Pharmacological evidence for two kinds of GABA receptors on rat
hippocampal pyramidal cells studied in vitro. Journal of Physiology (London), 328, 125- 141.
Alger, B. E. (1991). Gating of GABAergic inhibition in hippocampal pyramidal cells. Annals of the New York Academy of Sciences, 627(1), 249-263.
Amaral, D., Lavenex, P. (2007). Hippocampal neuroanatomy. The Hippocampus Book, 1, 37- 114, Oxford U Press publication.
Amaral, D., Witter, M. (1989). The three-dimensional organization of the hippocampal formation: A review of anatomical data. Neuroscience, 31(3), 571-591.
Andersen, P., Bliss, T., Skrede, K. K. (1971). Lamellar organization of hippocampal excitatory pathways. Experimental Brain Research, 13(2), 222-238.
Andersen, P., Bliss, T., Skrede, K. (1971). Unit analysis of hippocampal population spikes. Experimental Brain Research, 13(2), 208-221.
Andrade, R., Malenka, R., Nicoll, R. (1986). AG protein couples serotonin and GABA-B receptors to the same channels in hippocampus. Science, 234(4781), 1261-1265.
Anisman, H., McIntyre, D. C. (2002). Conceptual, spatial, and cue learning in the morris water maze in fast or slow kindling rats: Attention deficit comorbidity. The Journal of Neuroscience, 22(17), 7809-7817.
Asprodini, E. K., Rainnie, D. G., Shinnick-Gallagher, P. (1992). Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acidB receptors on glutamatergic afferents in the amygdala. Journal of Pharmacology and Experimental Therapeutics, 262(3), 1011-1021.
Avishai-Eliner, S., Brunson, K. L., Sandman, C. A., Baram, T. Z. (2002). Stressed-out, or in (utero)? Trends in Neurosciences, 25(10), 518-524.
Badran, S., Schmutz, M., Olpe, H. (1997). Comparative in vivo and in vitro studies with the potent GABA-B receptor antagonist, CGP 56999A. European Journal of Pharmacology, 333(2), 135-142.
55
Bai, D., Zhu, G., Pennefather, P., Jackson, M. F., MacDonald, J. F., Orser, B. A. (2001). Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by γ-aminobutyric acidA receptors in hippocampal neurons. Molecular Pharmacology, 59(4), 814-824.
Barnard, E., Skolnick, P., Olsen, R., Mohler, H., Sieghart, W., Biggio, G., Langer, S. (1998). International union of pharmacology. XV. subtypes of γ-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function. Pharmacological Reviews, 50(2), 291-314.
Ben-Ari, Y., Holmes, G. L. (2006). Effects of seizures on developmental processes in the immature brain. The Lancet Neurology, 5(12), 1055-1063.
Ben-Ari, Y., Represa, A. (1990). Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends in Neurosciences, 13(8), 312-318. Benarroch, E. E. (2007). GABA-A receptor heterogeneity, function, and implications for
epilepsy. Neurology, 68(8), 612-614.
Benes, F. M., Berretta, S. (2001). GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology, 25(1), 1-27.
Berg, A. T., Shinnar, S. (1997). Do seizures beget seizures? an assessment of the clinical evidence in humans. Journal of Clinical Neurophysiology, 14(2), 102-110.
Bettler, B., Kaupmann, K., Mosbacher, J., Gassmann, M. (2004). Molecular structure and physiological functions of GABAB receptors. Physiological Reviews, 84(3), 835-867. Billinton, A., Baird, V. H., Thom, M., Duncan, J. S., Upton, N., Bowery, N. G. (2001). GABA-
B (1) mRNA expression in hippocampal sclerosis associated with human temporal lobe epilepsy. Molecular Brain Research, 86(1), 84-89.
Billinton, A., Baird, V. H., Thom, M., Duncan, J. S., Upton, N., Bowery, N. G. (2001). GABA- B receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy. British Journal of Pharmacology, 132(2), 475-480.
Bowery, N. (1993). GABA-B receptor pharmacology. Annual Review of Pharmacology and Toxicology, 33(1), 109-147.
Bowery, N., Hill, D., Hudson, A. (1985). [3H](−) baclofen: An improved ligand for GABA- B sites. Neuropharmacology, 24(3), 207-210.
Bowery, N., Hudson, A., Price, G. (1987). GABA-A and GABA-B receptor site distribution in the rat central nervous system. Neuroscience, 20(2), 365-383.
Bowery, N., Pratt, G. (1992). GABA-B receptors as targets for drug action. Arzneimittel- Forschung, 42(2A), 215-223.
56
Brivanlou, I. H., Dantzker, J. L., Stevens, C. F., Callaway, E. M. (2004). Topographic specificity of functional connections from hippocampal CA3 to CA1. Proceedings of the National Academy of Sciences of the United States of America, 101(8), 2560-2565. Brooks-Kayal, A. R., Shumate, M. D., Jin, H., Rikhter, T. Y., Coulter, D. A. (1998). Selective
changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy. Nature Medicine, 4(10), 1166-1172.
Buhl, E., Han, Z., Lorinczi, Z., Stezhka, V., Karnup, S., Somogyi, P. (1994). Physiological properties of anatomically identified axo-axonic cells in the rat hippocampus. Journal of Neurophysiology, 71(4), 1289-1307.
Burgard, E. C., Sarvey, J. M. (1991). Long-lasting potentiation and epileptiform activity produced by GABAB receptor activation in the dentate gyrus of rat hippocampal slice. The Journal of Neuroscience, 11(5), 1198-1209.
Buzsaki, G., Eidelberg, E. (1982). Convergence of associational and commissural pathways on CA1 pyramidal cells of the rat hippocampus. Brain Research, 237(2), 283-295.
Buzsaki, G., Eidelberg, E. (1982). Convergence of associational and commissural pathways on CA1 pyramidal cells of the rat hippocampus. Brain research, 237(2), 283-295.
Caillard, O., McLean, H. A., Ben-Ari, Y., Gaïarsa, J. (1998). Ontogenesis of presynaptic GABA-B receptor-mediated inhibition in the CA3 region of the rat hippocampus. Journal of Neurophysiology, 79(3), 1341-1348.
Camfield, C., Camfield, P. (2002). Death in children with epilepsy. The Lancet, 360(9346), 1698-1699.
Cendes, F., Andermann, F., Dubeau, F., Gloor, P., Evans, A., Jones-Gotman, M., Lopes- Cendes, I. (1993). Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy an MRI volumetric study. Neurology, 43(6), 1083-1083.
Chandler, K. E., Princivalle, A. P., Fabian-Fine, R., Bowery, N. G., Kullmann, D. M., Walker, M. C. (2003). Plasticity of GABAB receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus. The Journal of Neuroscience, 23(36), 11382-11391. Chen, K., Baram, T. Z., Soltesz, I. (1999). Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nature Medicine, 5(8), 888-894.
Cilio, M. R., Sogawa, Y., Cha, B., Liu, X., Huang, L., Holmes, G. L. (2003). Long‐term effects of status epilepticus in the immature brain are specific for age and model. Epilepsia, 44(4), 518-528.
Corrêa, S. A., Munton, R., Nishimune, A., Fitzjohn, S., Henley, J. M. (2004). Development of GABA-B subunits and functional GABA- B receptors in rat cultured hippocampal neurons. Neuropharmacology, 47(4), 475-484.
57
Couve, Andrés, Stephen J. Moss, and Menelas N. Pangalos. "GABA-B Receptors: A New Paradigm in G Protein Signaling." Molecular and Cellular Neuroscience 16.4 (2000): 296-312.
Davies, C. H., Starkey, S. J., Pozza, M. F., Collingridge, G. L. (1991). GABAB autoreceptors regulate the induction of LTP. Nature 349, 609 – 611.
Dufresne, C. (1990). Seizure development in kindling fast and kindling slow rat strains. Unpublished master thesis, Carleton University, Ottawa, Ontario, Canada.
Durand, Guylaine M., Yury Kovalchuk, and Arthur Konnerth. (1996). Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381, 71 - 75. Essrich, C., Lorez, M., Benson, J. A., Fritschy, J., Lüscher, B. (1998). Postsynaptic clustering of
major GABAA receptor subtypes requires the γ2 subunit and gephyrin. Nature
Neuroscience, 1(7), 563-571.
Eugène, E., Depienne, C., Baulac, S., Baulac, M., Fritschy, J. M., Le Guern, E., Poncer, J. C. (2007). GABA-A receptor γ2 subunit mutations linked to human epileptic syndromes
differentially affect phasic and tonic inhibition. The Journal of Neuroscience, 27(51), 14108-14116.
Fischer, Y., Gähwiler, B. H., Thompson, S. M. (1999). Activation of intrinsic hippocampal theta oscillations by acetylcholine in rat septo-hippocampal cocultures. The Journal of Physiology, 519(2), 405-413.
Freund, T., Buzsáki, G. (1996). Interneurons of the hippocampus. Hippocampus, 6(4), 347-470. Francis, J., Zhang, Y., Ho, W., Wallace, M.C., Zhang, L., Eubanks, J.H., 1999. Decreased
hippocampal expression, but not functionality, of GABA(B) receptors after transient cerebral ischemia in rats. J. Neurochem. 72, 87–94
Friedman, L. K., Pellegrini-Giampietro, D. E., Sperber, E., Bennett, M., Moshe, S., Zukin, R. (1994). Kainate-induced status epilepticus alters glutamate and GABA-A receptor gene expression in adult rat hippocampus: An in situ hybridization study. The Journal of Neuroscience, 14(5), 2697-2707.
Fritschy, J., Meskenaite, V., Weinmann, O., Honer, M., Benke, D., Mohler, H. (1999). GABAB‐receptor splice variants GB1a and GB1b in rat brain: Developmental regulation, cellular distribution and extrasynaptic localization. European Journal of Neuroscience, 11(3), 761-768.
Fukuda, A., Mody, I., Prince, D. A. (1993). Differential ontogenesis of presynaptic and postsynaptic GABAB inhibition in rat somatosensory cortex. Journal of Neurophysiology, 70(1), 448-452.
Furtinger, S., Bettler, B., Sperk, G. (2003). Altered expression of GABA-B receptors in the hippocampus after kainic-acid-induced seizures in rats. Molecular Brain Research, 113(1), 107-115.
58
Furtinger, S., Pirker, S., Czech, T., Baumgartner, C., Sperk, G. (2003). Increased expression of
γ-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy. Neuroscience Letters, 352(2), 141-145.
Gaiarsa, J., McLean, H., Congar, P., Leinekugel, X., Khazipov, R., Tseeb, V., Ben‐Ari, Y.
(1995). Postnatal maturation of gamma‐aminobutyric acidA and B‐mediated inhibition in the CA3 hippocampal region of the rat. Journal of Neurobiology, 26(3), 339-349. Gaiarsa, J., Tseeb, V., Ben-Ari, Y. (1995). Postnatal development of pre-and postsynaptic
GABAB-mediated inhibitions in the CA3 hippocampal region of the rat. Journal of Neurophysiology, 73(1), 246-255.
Gale, K. (1992). Role of GABA in the genesis of chemoconvulsant seizures. Toxicology Letters, 64, 417-428.
Gambardella, A., Manna, I., Labate, A., Chifari, R., La Russa, A., Serra, P., LePiane, E. (2003). GABA (B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. Neurology, 60(4), 560-563.
Garant, D., Sperber, E., Moshé, S. (1992). The density of GABA-B binding sites in the substantia nigra is greater in rat pups than in adults. European Journal of Pharmacology, 214(1), 75-78.
Haas, K. Z., Sperber, E. F., Moshé, S. L., Stanton, P. K. (1996). Kainic acid-induced seizures enhance dentate gyrus inhibition by downregulation of GABAB receptors. The Journal of Neuroscience, 16(13), 4250-4260.
Haas, K. Z., Sperber, E. F., Opanashuk, L. A., Stanton, P. K., Moshé, S. L. (2001). Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling. Hippocampus, 11(6), 615-625.
Halasy, K., Buhl, E. H., Lörinczi, Z., Tamás, G., Somogyi, P. (1996). Synaptic target selectivity and input of GABAergic basket and bistratified interneurons in the CA1 area of the rat hippocampus. Hippocampus, 6(3), 306-329.
Hauser, W. A. (1995). Epidemiology of epilepsy in children. Neurosurgery clinics of North America, 6(3), 419.
Henschel, O., Gipson, K. E., Bordey, A. (2008). GABAA receptors, anesthetics and anticonvulsants in brain development. CNS & Neurological Disorders Drug Targets, 7(2), 211.
Hershman, K. M., Freedman, R., Bickford, P. C. (1995). GABA-B antagonists diminish the inhibitory gating of auditory response in the rat hippocampus. Neuroscience Letters, 190(2), 133-136.
Hill, D. (1985). GABAB receptor modulation of adenylate cyclase activity in rat brain slices. British Journal of Pharmacology, 84(1), 249.
59
Holmes, G. L., Ben-Ari, Y. (2001). The neurobiology and consequences of epilepsy in the developing brain. Pediatric Research, 49(3), 320-325.
Holmes, G. L., Thompson, J. L., Marchi, T., Feldman, D. S. (1988). Behavioral effects of kainic acid administration on the immature brain. Epilepsia, 29(6), 721-730.
Isaacson, J., Solis, J., Nicoll, R. (1993). Local and diffuse synaptic actions of GABA in the hippocampus. Neuron, 10(2), 165-175.
Isaacson, R. L. (1980). A perspective for the interpretation of limbic system function. Physiological Psychology,
Isaeva, E., Isaev, D., Khazipov, R., Holmes, G. L. (2006). Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. European Journal of Neuroscience, 23(6), 1559-1566.
Kang, J., Shen, W., Macdonald, R. L. (2006). Why does fever trigger febrile seizures? GABA-A receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. The Journal of Neuroscience, 26(9), 2590-2597.
Kapur, J., Stringer, J. L., Lothman, E. W. (1989). Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. Journal of Neurophysiology, 61(2), 417-426.
Kennedy, R. T., Thompson, J. E., Vickroy, T. W. (2002). In vivo monitoring of amino acids by direct sampling of brain extracellular fluid at ultralow flow rates and capillary electrophoresis. Journal of Neuroscience Methods, 114(1), 39-49.
Khirug, S., Ahmad, F., Puskarjov, M., Afzalov, R., Kaila, K., Blaesse, P. (2010). A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus. The Journal of Neuroscience, 30(36), 12028-12035.
Kiernan, J., Rajakumar, R. (2013). Barr's The human nervous system: an anatomical viewpoint. LWW.
Knowles, W. D. (1992). Normal anatomy and neurophysiology of the hippocampal formation. Journal of Clinical Neurophysiology, 9(2), 253-263.
Krampfl, K., Maljevic, S., Cossette, P., Ziegler, E., Rouleau, G. A., Lerche, H., Bufler, J. (2005). Molecular analysis of the A322D mutation in the GABA-A receptor α1‐subunit
causing juvenile myoclonic epilepsy. European Journal of Neuroscience, 22(1), 10-20. Lacaille, J. (1991). Postsynaptic potentials mediated by excitatory and inhibitory amino acids in
interneurons of stratum pyramidale of the CA1 region of rat hippocampal slices in vitro. Journal of Neurophysiology, 66(5), 1441-1454.
Lambert, N. A., Wilson, W. A. (1994). Temporally distinct mechanisms of use-dependent depression at inhibitory synapses in the rat hippocampus in vitro. Journal of Neurophysiology, 72(1), 121-130.
60
Lauren, H., Lopez‐Picon, F., Korpi, E. R., Holopainen, I. (2005). Kainic acid‐induced status
epilepticus alters GABAA receptor subunit mRNA and protein expression in the developing rat hippocampus. Journal of Neurochemistry, 94(5), 1384-1394.
Laurie, D., Wisden, W., Seeburg, P. (1992). The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. embryonic and postnatal development. The Journal of Neuroscience, 12(11), 4151-4172.
Leite, J. P., Babb, T. L., Pretorius, J. K., Kuhlman, P. A., Yeoman, K. M., Mathern, G. W. (1996). Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats. Epilepsy Research, 26(1), 219-231.
Lerma, J., Herranz, A. S., Herreras, O., Abraira, V., Del Rio, R. M. (1986). In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Research, 384(1), 145- 155.
Leung, L.S. (2010) Field potential generation and current source density analysis. In: Electrophysiological Recording Techniques, Vertes RP and Stackman RW (Eds.), Humana Press, Clifton, N.J., NeuroMethods Volume 54:1-26.
Leung, L.S., Fu, X. (1994). Factors affecting paired-pulse facilitation in hippocampal CA1 neurons in vitro. Brain Research, 650(1), 75-84.
Leung, L. S., Canning, K. J., Shen, B. (2005). Hippocampal afterdischarges after GABAB‐Receptor blockade in the freely moving rat. Epilepsia, 46(2), 203-216.
Leung, L. S., Peloquin, P., Canning, K. J. (2008). Paired‐pulse depression of excitatory
postsynaptic current sinks in hippocampal CA1 in vivo. Hippocampus, 18(10), 1008- 1020.
Leung, L., Ma, J., McLachlan, R. (2000). Behaviors induced or disrupted by complex partial seizures. Neuroscience Biobehavioral Reviews, 24(7), 763-775.
Lewis, D. V., Jones, L. S., Mott, D. D. (1989). Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. Experimental Neurology, 106(2), 181-186.
Li, X., Zhou, J., Chen, Z., Chen, S., Zhu, F., Zhou, L. (2008). Long-term expressional changes of na -K -cl-co-transporter 1 (NKCC1) and K -cl-co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE). Brain Research, 1221, 141-146.
Lipscomb, D., Meredith, T. (1980). Baclofen overdose. Postgraduate Medical Journal, 56(652), 108-109.
Liu, X., Leung, L. S. (2003). Partial hippocampal kindling increases GABA-Breceptor-mediated postsynaptic currents in CA1 pyramidal cells. Epilepsy Research, 57(1), 33-47.
Lopes da Silva, F. H., Witter, M., Boeijinga, P., Lohman, A. (1990). Anatomic organization and physiology of the limbic cortex. Physiological Reviews, 70(2), 453-511.
61
Lorente de N6, R. (1933). Studies on the structure of the cerebral cortex. I. the area entorhinalis. J.Psychol.Neurol., Lpz, 45, 381-438.
Lorente de Nó, R. (1934). Studies on the structure of the cerebral cortex. II. continuation of the study of the ammonic system. Journal für Psychologie und Neurologie, Vol 46, 1934, 113-177.
Lothman, E. W., Stringer, J. L., Bertram, E. H. (1992). The dentate gyrus as a control point for seizures in the hippocampus and beyond. Epilepsy Research.Supplement, 7, 301-313. Loup, F., Wieser, H., Yonekawa, Y., Aguzzi, A., Fritschy, J. (2000). Selective alterations in
GABAA receptor subtypes in human temporal lobe epilepsy. The Journal of Neuroscience, 20(14), 5401-5419.
Lynch, M., Sayin, Ü., Bownds, J., Janumpalli, S., Sutula, T. (2000). Long‐term consequences
of early postnatal seizures on hippocampal learning and plasticity. European Journal of Neuroscience, 12(7), 2252-2264.
Macdonald, R., McLean, M. (1985). Anticonvulsant drugs: Mechanisms of action. Advances in Neurology, 44, 713-736.
Maher, J., McLachlan, R. S. (1995). Febrile convulsions is seizure duration the most important predictor of temporal lobe epilepsy? Brain, 118(6), 1521-1528.
Mangan, P. S., Lothman, E. W. (1996). Profound disturbances of pre-and postsynaptic GABAB- receptor-mediated processes in region CA1 in a chronic model of temporal lobe epilepsy. Journal of Neurophysiology, 76(2), 1282-1296.
Marty, S., Berninger, B., Carroll, P., Thoenen, H. (1996). GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron, 16(3), 565-570.
Mason, S. T., Corcoran, M. E. (1979). Seizure susceptibility after depletion of spinal or cerebellar noradrenaline with 6-OHDA. Brain Research, 166(2), 418-421.
Maytal, J., Shinnar, S., Moshé, S. L., Alvarez, L. A. (1989). Low morbidity and mortality of status epilepticus in children. Pediatrics, 83(3), 323-331.
McGeer, E. G., Olney, J. W., McGeer, P. L. (1978). Kainic acid as a tool in neurobiology. Raven press, New York.
McIntyre, D. C. (1980). Amygdala kindling in rats: Facilitation after local amygdala norepinephrine depletion with 6-hydroxydopamine. Experimental Neurology, 69(2), 395-407.
McIntyre, D. C., Hutcheon, B., Schwabe, K., Poulter, M. O. (2002). Divergent GABA-A receptor-mediated synaptic transmission in genetically seizure-prone and seizure- resistant rats. The Journal of Neuroscience, 22(22), 9922-9931.
62
McIntyre, D. C., Kelly, M. E., Dufresne, C. (1999). FAST and SLOW amygdala kindling rat strains: Comparison of amygdala, hippocampal, piriform and perirhinal cortex kindling. Epilepsy Research, 35(3), 197-209.
Megıas, M., Emri, Z., Freund, T., Gulyas, A. (2001). Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience, 102(3), 527-540.
Miller, C., Freedman, R. (1995). The activity of hippocampal interneurons and pyramidal cells during the response of the hippocampus to repeated auditory stimuli. Neuroscience, 69(2), 371-381.
Misgeld, U., Klee, M., Zeise, M. (1984). Differences in baclofen-sensitivity between CA3 neurons and granule cells of the guinea pig hippocampus in vitro. Neuroscience Letters, 47(3), 307-311.
Misgeld, U., Bijak, M., Jarolimek, W. (1995). A physiological role for GABA-B receptors and the effects of baclofen in the mammalian central nervous system. Progress in Neurobiology, 46(4), 423-462.
Mizielinska, S., Greenwood, S., Connolly, C. (2006). The role of GABA-A receptor biogenesis, structure and function in epilepsy. Biochemical Society Transactions, 34(Pt 5), 863-867. Mody, I., De Koninck, Y., Otis, T., Soltesz, I. (1994). Bridging the cleft at GABA synapses in
the brain. Trends in Neurosciences, 17(12), 517-525.
Moehler, H. (2006). GABA A receptors in central nervous system disease: Anxiety, epilepsy, and insomnia. Journal of Receptors and Signal Transduction, 26(5-6), 731-740.
Mohapel, P., McIntyre, D. C. (1998). Amygdala kindling-resistant (SLOW) or-prone (FAST) rat strains show differential fear responses. Behavioral Neuroscience, 112(6), 1402.
Morgane, P. J., Galler, J. R., Mokler, D. J. (2005). A review of systems and networks of the limbic forebrain/limbic midbrain. Progress in Neurobiology, 75(2), 143-160.
Morrisett, R., Mott, D., Lewis, D., Swartzwelder, H., Wilson, W. (1991). GABAB-receptor- mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. The Journal of Neuroscience, 11(1), 203-209.
Mueller, A. L., Taube, J. S., Schwartzkroin, P. A. (1984). Development of hyperpolarizing inhibitory postsynaptic potentials and hyperpolarizing response to gamma-aminobutyric acid in rabbit hippocampus studied in vitro. The Journal of Neuroscience, 4(3), 860-867. Muller, D., Lynch, G. (1989). Evidence that changes in presynaptic calcium currents are not responsible for long-term potentiation in hippocampus. Brain Research, 479(2), 290-299. Mumby, D. G., Gaskin, S., Glenn, M. J., Schramek, T. E., Lehmann, H. (2002). Hippocampal