Wendy Tupa Salas Para optar el Título Profesional de Médico
JUSTIFICACIÓN DEL PROBLEMA
F. DIAGNÓSTICO
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Study Questions 1. Describe briefly major aspects of the structure,
properties, locations, and functions of each of the following proteins of skeletal muscle.
Actin Tropomyosin Myosin Troponin Titin Myomesin Nebulin Desmin α-Actinin Vimentin C-protein
2. Describe the generally accepted sliding filament model of muscle contraction. List some uncertain- ties in this description.
3. Compare mechanisms that regulate contraction in skeletal muscle and in smooth muscle.
4. Compare myosin with kinesins and dyneins. What features do they have in common? What differences can you describe?
5. Compare the properties of actin in skeletal muscle and in nonmuscle cells. What is meant by
“treadmilling?” What is “actin-based motility?” 6. The human genome contains more than 100 genes
for proteins of the kinesin superfamily. Why? 7. Describe some of the major diseases that involve
muscle proteins. References
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