DISEÑO DEL SISTEMA: Moodle

The past two decades have seen promising results from peanut immunotherapies in clinical trials. These are likely to become the first FDA-approved therapies for food allergies. However, they come with their limitations, requiring the discovery of new future therapies. The allergy field has seen an explosion of research into disease etiology, specifically the

contributions of the microbiome and genetics to the development of food allergy. The ultimate goal of these studies is to identify targets for future therapies. The findings presented here contribute greatly to possible future developments. These results provide mechanistic insight into investigational allergen immunotherapies, suggesting that antibody functional differences are important for clinical outcome in OIT. Additionally, a novel treatment approach that targets peanut-specific B cells for deletion is described in a mouse model of peanut allergy. Perhaps the greatest contribution of all is the development of an improved food allergy model that can be used to better understand causes of the disease and allows for the identification of new therapy targets. Together, these findings provide the foundation for future allergy treatments.

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