MESES ACTIVIDADES
7. TÉCNICAS UTILIZADAS PARA LA RECOLECCIÓN DE LA INFORMACIÓN ETAPA
8.2 ANÁLISIS CLIMÁTICO
8.2.2.4 Distribución de Weibull
1. Ahlfors, Helena: Interleukin-4 induced leukocyte differentiation.
University of Turku, p. 145
2. Ahlskog, Johanna: Regulation of heat shock transcription
factors by ubiquitin and ubiquitin-like modifiers. Åbo Akademi University, p. 139
3. Blomster, Henri: Cellular regulation of SUMO modification by
alternative targeting mechanisms. Åbo Akademi University, p. 145
4. Filén, Sanna: ATF3 and GIMAP family proteins 1 and 4 in
human T helper cell differentiation. Åbo Akademi University, p. 145
5. Kouvonen, Petri: Simplified sample handling in mass
spectrometry based protein research. University of Turku, p.106
6. Kukkonen-Macchi, Anu: Functional characterization of proteins
required for mitotic progression and the spindle assembly checkpoint. University of Turku, p. 96
7. Pallari, Hanna-Mari: Dynamic interplay between the
intermediate filament protein nestin and Cyclin-dependent kinase 5. Åbo Akademi University, p. 111
8. Peuhu, Emilia: Lethal Weapons - Novel approaches for
receptor-targeted cancer cell elimination. Åbo Akademi
University, p. 179
9. Sandqvist, Anton: HSF1-HSF2 heterotrimerization as a
transcriptional switch and miR-18 mediated regulation of HSF2. Åbo Akademi University, p.140
10. Tahvanainen, Johanna: New mechanisms regulating human
Th1 and Th2 cell differentiation. University of Turku, p. 175
11. Tiikkainen, Pekka: Study of ligand-based virtual screening
tools in computer-aided drug design. University of Turku, p. 98
12. Toivonen, Raine: Targeting adenoviral gene therapy vectors to
HNSCC and heart. University of Turku, p. 103
13. Tuomi, Saara: The integrin tail: A tail of motility and division.
University of Turku, p.166
14. Vuoriluoto, Karoliina: Anchor or accelerate – a study on cancer
cell adhesion and mobility. University of Turku, p.162
Publications 2010
1. Aittokallio, T. 2010. Dealing with missing values in large-scale
studies – microarray data imputation and beyond. Briefings in Bioinformatics, 11: 253-264.
2. Ahlfors H., Limaye A., Elo L.L., Tuomela S., Burute M.,
Gottimukkala K.V., Notani D., Rasool O., Galande S., Lahesmaa R. 2010. SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation. Blood, 116(9):1443-1453.
3. Ahlskog J.K., Björk J.K., Elsing A.N., Aspelin C., Kallio M.,
Roos-Mattjus P., Sistonen L. 2010. Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol. Cell. Biol., 30(24):5608-5620.
N.E. 2010. Investigation of the role of conserved residues Ser13, Asn48 and Pro49 in the catalytic mechanism of the tau class glutathione transferase from Glycine max. Biochim. Biophys. Acta, 1804(4):662-667.
5. Björk J.K., Sandqvist A., Elsing A.N., Kotaja N., Sistonen L.
2010. miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis. Development, 137(19):3177-3184.
6. Björk J.K., Sistonen L. 2010. Regulation of the members of the
mammalian heat shock factor family. FEBS J., 277(20):4126- 4139.
7. Blom T., Bergelin N., Meinander A., Löf C., Slotte J.P.,
Eriksson J.E., Törnquist K. 2010. An autocrine sphingosine-1- phosphate signaling loop enhances NF-kappaB-activation and survival. BMC Cell Biol., 11:45.
8. Blomster H.A., Imanishi S.Y., Siimes J., Kastu J., Morrice
N.A., Eriksson J.E., Sistonen L. 2010. In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J. Biol. Chem., 285(25):19324-19329.
9. Das D., Lanner F., Main H., Andersson E.R., Bergmann O.,
Sahlgren C., Heldring N., Hermanson O., Hansson E.M., Lendahl U. 2010. Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells. Dev. Biol., 15;348(2):153-166.
10. de Thonel A., Ferraris S.E., Pallari H.M., Imanishi S.Y., Kochin
V., Hosokawa T., Hisanaga S., Sahlgren C., Eriksson J.E. 2010. Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis. Mol. Biol. Cell, 21(8):1423-1434.
11. Diamandis E.P., Hudson T., Kallioniemi O., Liu E.T., López-Otín
C. 2010. Cancer Genomes. Clin. Chem., 6 (11):1660-1664
12. Dias J.D., Guse K., Nokisalmi P., Eriksson M., Chen
D.T., Diaconu I., Tenhunen M., Liikanen I., Grénman R., Savontaus M., Pesonen S., Cerullo V., Hemminki A. 2010. Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures. Eur. J. Cancer, 46(3):625-635.
13. do Carmo Costa M., Bajanca F., Rodrigues A.J., Tomé R.J.,
Corthals G., Macedo-Ribeiro S., Paulson H.L., Logarinho E., Maciel P. 2010. Ataxin-3 plays a role in mouse myogenic differentiation through regulation of integrin subunit levels. PLoS One, 5(7):e11728.
14. Elo L.L., Järvenpää H., Tuomela S., Raghav S., Ahlfors H.,
Laurila K., Gupta B., Lund R.J., Tahvanainen J., Hawkins R.D., Oresic M., Lähdesmäki H., Rasool O., Rao K.V., Aittokallio T., Lahesmaa R. 2010. Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity, 32(6):852-862.
15. Elo L.L., Mykkänen J., Nikula T., Järvenpää H., Simell S.,
Aittokallio T., Hyöty H., Ilonen J., Veijola R., Simell T., Knip M., Simell O., Lahesmaa R. 2010. Early suppression of immune response pathways characterizes children with prediabetes
in genome-wide gene expression profiling. J. Autoimmun., 35(1):70-76.
16. Filén S., Ylikoski E., Tripathi S., West A., Björkman M., Nyström
J., Ahlfors H., Coffey E., Rao K.V., Rasool O., Lahesmaa R. 2010. Activating transcription factor 3 is a positive regulator of human IFNG gene expression. J. Immunol., 184(9):4990- 4999.
17. Filén S., Lahesmaa R. GIMAP Proteins in T-Lymphocytes.
2010. Journal of Signal Transduction. Volume 2010, Article ID 268589
18. Gupta S., Iljin K., Sara H., Mpindi J.P., Mirtti T., Vainio P.,
Rantala J., Alanen K., Nees M., Kallioniemi O. 2010. FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res., 70(17):6735-6745.
19. Haikarainen T., Tsou C.C., Wu J.J, Papageorgiou A.C.
Structural characterization and biological implications of di-zink binding in the ferroxidase center of Strepococcus pyogenes Dpr. Biochem. Biophys. Res. Comm., 398:361-365.
20. Haikarainen T., Papageorgiou A.C. 2010. Dps-like proteins:
Structural and functional insights into a versatile protein family. Cell. Mol. Life Sci., 67:341-251
21. Heikkinen P.T., Nummela M., Jokilehto T., Grenman R., Kähäri
V.-M., Jaakkola P.M. 2010. Hypoxic conversion of SMAD7 function from an inhibitor into a promoter of cell invasion. Cancer Res., 70(14):5984-5993.
22. Heikkinen P.T., Nummela M., Leivonen S.K., Westermarck J.,
Hill C.S., Kähäri V.-M., Jaakkola P.M. 2010. Hypoxia activated Smad3-spesific dephosphorylation by PP2A. J Biol. Chem., 285(6):3740-3749.
23. Härmä V., Virtanen J., Mäkelä R., Happonen A., Mpindi J.P.,
Knuuttila M., Kohonen P., Lötjönen J., Kallioniemi O., Nees M. 2010. A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS One, 5(5):e10431.
24. Ivaska J, Heino J. 2010. Interplay between cell adhesion and
growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res., 339(1):111-120.
25. Jaakkola U., Kakko, T., Seppälä H., Vainio-Jylhä E., Vahlberg T.,
Raitakari OT., Kallio J. 2010: The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes. Microvasc. Res., 80(3):433-439.
26. Jokilehto T., Högel H., Heikkinen P., Rantanen K., Elenius
K., Sundström J., Jaakkola P.M. 2010. Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Exp. Cell Res., 316(7):1169-1178.
27. Jokilehto T., Jaakkola P.M. 2010. The role of HIF prolyl
hydroxylases in tumour growth. J. Cell Mol. Med., 14(4):758- 770.
28. Kankare M., Salminen T., Laiho A., Vesala L., Hoikkala A. 2010.
Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study. BMC Ecol., 10:3.
29. Kerosuo L., Fox H., Perälä N., Ahlqvist K., Suomalainen A.,
Westermarck J., Sariola H., Wartiovaara K. 2010. CIP2A increases self-renewal and is linked to Myc in neural progenitor cells. Differentiation, 80(1):68-77.
30. Korolainen M.A., Nyman T.A., Aittokallio T., Pirttilä T. 2010.
An update on clinical proteomics in Alzheimer’s research. J Neurochem., 112(6):1386-1414
31. Labrou N.E., Papageorgiou A.C., Avramis V.I. 2010.
Structure-function relationships and clinical applications of L-asparaginases. Curr. Med. Chem., 17(20):2183-2195.
32. Main H., Lee K.L., Yang H., Haapa-Paananen S., Edgren
H., Jin S., Sahlgren C., Kallioniemi O., Poellinger L., Lim B., Lendahl U. 2010. Interactions between Notch- and hypoxia- induced transcriptomes in embryonic stem cells. Exp. Cell Res., 316(9):1610-1624.
33. Matlawska-Wasowska K, Finn R, Mustel A, O’Byrne CP, Baird
AW, Coffey ET, Boyd A. The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis. BMC Microbiol., 2010 Dec 30;10:329.
34. Mattila E, Marttila H, Sahlberg N, Kohonen P, Tähtinen S,
Halonen P, Perälä M, Ivaska J. 2010. Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase. BMC Cancer, 10:7.
35. McDonnell L.A., Corthals G.L., Willems S.M., van Remoortere
A., van Zeijl R.J., Deelder A.M. 2010. Peptide and protein imaging mass spectrometry in cancer research. J. Proteomics, 73(10):1921-1944.
36. Medina-Aunon J.A., Paradela A., Macht M., Thiele H., Corthals
G., Albar J.P. 2010. Protein Information and Knowledge Extractor: Discovering biological information from proteomics data. Proteomics, 10(18):3262-3271.
37. Melissis S.C., Papageorgiou A.C., Labrou N.E., Clonis Y.D.
2010. Purification of M-MLVH- RT on a 9-aminoethyladenine- (1,6-diamine-hexane)-triazine selected from a combinatorial library of dNTP-mimetic ligands. J. Chromatogr. Sci., 48(6):496- 502.
38. Moulder R., Lönnberg T., Elo L.L., Filén J.J., Rainio E., Corthals
G., Oresic M., Nyman T.A., Aittokallio T., Lahesmaa R. 2010. Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation. Mol. Cell Proteomics, 9(9):1937-1953.
39. Nevo J, Mai A, Tuomi S, Pellinen T, Pentikäinen OT, Heikkilä
P, Lundin J, Joensuu H, Bono P, Ivaska J. 2010. Mammary- derived growth inhibitor (MDGI) interacts with integrin
α-subunits and suppresses integrin activity and invasion. Oncogene, 29(49):6452-6463.
40. Niinisalo P., Oksala N., Levula M., Pelto-Huikko M., Järvinen O.,
Salenius J.P., Kytömäki L., Soini J.T., Kähönen M., Laaksonen R., Hurme M., Lehtimäki T. 2010. Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study. Ann. Med., 42(1):55-63.
41. Närvä E., Autio R., Rahkonen N., Kong L., Harrison N.,
Kitsberg D., Borghese L., Itskovitz-Eldor J., Rasool O., Dvorak P., Hovatta O., Otonkoski T., Tuuri T., Cui W., Brüstle O., Baker D., Maltby E., Moore H.D., Benvenisty N., Andrews P.W., Yli- Harja O., Lahesmaa R. 2010. High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nat. Biotechnol., 28(4):371-377.
42. Oksala N., Levula M., Pelto-Huikko M., Kytömäki L., Soini
J.T., Salenius J., Kähönen M., Karhunen P.J., Laaksonen R., Parkkila S., Lehtimäki T. 2010. Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study. Ann. Med., 42(5):360-70.
43. Ovaska K., Laakso M., Haapa-Paananen S, Louhimo R.,
Chen P., Aittomäki V., Valo E., Núñez-Fontarnau J., Rantanen V., Karinen S., Nousiainen K., Lahesmaa-Korpinen A.M., Miettinen M., Saarinen L., Kohonen P., Wu J., Westermarck J., Hautaniemi S. 2010. Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme. Genome Med., 2(9):65.
44. Petre I., Mizera A., Hyder C.L., Meinander A., Mikhailov A.,
Morimoto R.I., Sistonen L., Eriksson J.E., Back R. J. 2010. A simple mass action model for the eukaryotic heat shock response and its mathematical validation. Natural Computing, pp.1-18-18.
45. Peuhu E., Kaunisto A., Laihia J.K., Leino L., Eriksson J.E.
2010. Molecular targets for the protodynamic action of cis- urocanic acid in human bladder carcinoma cells. BMC Cancer, 10:521.
46. Peuhu E., Rivero-Müller A.,Stykki H., Torvaldson E., Holmbom
T., Eklund P., Unkila M., Sjöholm R., Eriksson J.E. 2010. Inhibition of Akt signaling by the lignan matairesinol sentisitizes prostate cancer cells to TRAIL- induced apoptosis. Oncogene, 29:898-908.
47. Plantard L., Arjonen A., Lock J.G., Nurani G., Ivaska J.,
Strömblad S. 2010. PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation. J. Cell Sci., 123(Pt 20):3525-3534.
48. Podkowa M., Zhao X., Chow C.W., Coffey E.T., Davis
R.J., Attisano L. 2010. Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation. Mol. Cell Biol., 30(9):2241-2250.
49. Rantala J.K., Edgren H., Lehtinen L., Wolf M., Kleivi K., Moen
Vollan H.K., Aaltola A.-R., Laasola P., Kilpinen S., Saviranta P., Iljin K., Kallioniemi O. 2010. Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells indentifies an oncogenic profile role for GINS21,2. Neoplasia, 12(11):877-888.
50. Rosenholm J.M., Peuhu E., Bate-Eya L.T., Eriksson J.E.,
Sahlgren C., Lindén M. 2010. Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug- delivery vectors. Small, 6(11):1234-1241.
51. Rosenholm J.M., Sahlgren C., Lindén M. 2010. Towards
multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles -opportunities & challenges. Nanoscale, 2(10):1870-1883.
52. Santio N.M., Vahakoski R.L., Rainio E.M., Sandholm J.A.,
Virtanen S.S., Prudhomme M., Anizon F., Moreau P., Koskinen P.J. 2010. Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol. Cancer, 9(1):279.
53. Sara H., Kallioniemi O., Nees M. 2010. A decade of cancer
gene profiling: from molecular portraits to molecular function. Methods Mol. Biol., 576:61-87.
54. Shen W.J., Patel S., Eriksson J.E., Kraemer F.B. 2010 Vimentin
is a functional partner of hormone sensitive lipase and facilitates lipolysis. J. Proteome Res., 9(4):1786-1794.
55. Sirén A., Polvi A., Chahine L., Labuda M., Bourgoin S.,
Anttonen A.K., Kousi M., Hirvonen K., Simola K.O., Andermann E., Laiho A., Soini J., Koivikko M., Laaksonen R., Pandolfo M., Lehesjoki A.E. 2010. Suggestive evidence for a new locus for epilepsy with heterogeneous phenotypes on chromosome 17q. Epilepsy Res., 88(1):65-75.
56. Toivonen R., Mäyränpää M.I., Kovanen P.T., Savontaus M.
2010. Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart. Histochem. Cell Biol., 133(3):349-357.
57. Tuomela J., Grönroos T.J., Valta M.P., Sandholm J., Schrey
A., Seppänen J., Marjamäki P., Forsback S., Kinnunen I., Solin O., Minn H., Harkonen P.L. 2010. Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts. BMC Cancer, 10:596.
58. Uusi-Oukari M., Kontturi L.S., Coffey E.T., Kallinen S.A.
2010. AMPAR signaling mediating GABA(A)R delta subunit up-regulation in cultured mouse cerebellar granule cells. Neurochem. Int., 57(2):136-142.
59. Wakadkar S., Hermawan S., Jendrossek D., Papageorgiou
A.C. 2010. The structure of PhaZ7 at atomic (1.2 Å) resolution reveals details of the active site and suggests a substrate- binding mode. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 66(Pt 6):648-654.
60. Wakadkar S., Zhang L.Q., Li D.-C., Haikarainen T., Dhavala
P., Papageorgiou A.C. 2010. Expression, purification and crystallization of Chetonium thermophilium Cu, Zn superoxide dismutase. Acta Cryst. F Struct. Biol. Cryst. Commun., 66(Pt 9):1089-1092.
61. Westermarck J. 2010. Regulation of transcription factor
function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun. Methods Mol. Biol., 647:31-36.
62. Vihinen P.P., Hernberg M., Vuoristo M.S., Tyynelä K., Laukka
M., Lundin J., Ivaska J., Pyrhönen S. 2010. A phase II trial of bevacizumab with dacarbazine and daily low-dose interferon- alpha2a as first line treatment in metastatic melanoma. Melanoma Res., 20(4):318-325.
63. Åkerfelt M., Vihervaara A., Laiho A., Conter A., Christians E.S.,
Sistonen L., Henriksson E. 2010. Heat shock transcription factor 1 localizes to the sex chromatin during meiotic repression. J. Biol. Chem., 285:34469-34476.
64. Åkerfelt M., Morimoto R.I., Sistonen L. 2010. Heat shock
factors: integrators of cell stress, development and lifespan. Nat. Rev. Mol. Cell Biol., 11(8):545-555.