La escuela intercultural La educación intercultural es un modelo de intervención que debe generarse desde la escuela, y esta se debe entender como “un espacio privilegiado para

Our QSRR methodology can be used to predict the retention of β-

adrenergic agonists with a high degree of accuracy and precision over five

HILIC systems. The models are easily derived from a small set of β-

adrenergic agonists and their experimentally measured retention times. Quick theoretical calculations provide models that allow a researcher to readily distinguish suitable stationary phases for the study under development.

130 One of the novelties of the method described herein is the application of GA to select an optimised descriptor set for the QSRR models. The employment of optimised GA-PLS allowed us to identify the most relevant descriptors before obtaining the model, and to propose robust QSRR models, despite the high complexity of retention mechanisms in HILIC systems. In addition, models from GA-PLS based on the optimised descriptor sets outperformed those from GA-PLS and full PLS calculations, therefore we suggest the use of the former in the development of HILIC studies. Furthermore, the feature selection approach represented is shown to be a powerful tool to capture the general aspects of interactions for different HILIC systems.

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4 Rapid method development in hydrophilic interaction