OPORTUNIDADES VS EXPLOTAR
6.2.7. Estado de los intangibles.
Course director: DR.KÁLMÁN HIDEG, professor emeritus
Dept. of Organic and Pharmacological Chemistry
6 credit ▪ final exam ▪ Basic module ▪ spring semester ▪ recommended semester: 4
Number of hours/semester: 42 lectures + 42 practices + 0 seminars = total of 84 hours Course headcount limitations (min-max.): min. 2 – max. 60
Prerequisites: OPA-SV1 completed Topic
This subject is a part of chemistry basics. Its aim to present the nomenclature, structure, physical and chemical properties, synthesis, reaction mechanisms and application of organic compounds.
Conditions for acceptance of the semester
During the semester students have to accomplish the preparative works and written tests. They have to document the experiments in their exercise book.
Making up for missed classes
Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.
Reading material
John McMurry, Eric Simanek: Fundamentals of Organic Chemistry, 6th ed., Thomson Brooks, Belmont, 2007.
T. W. Graham Solomons: Organic Chemistry, 7th edition, Wiley and Sons, New York, 2000.
William H. Brown: Organic Chemistry, Saunders College Publishing, Fort Worth, 1995.
Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London,
1995.
Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed.,
Wiley, New York, 1994.
Lectures
1 Aldehydes and ketones; structure, physical, chemical properties, reactions, important representatives. Dr. Pápayné Dr. Sár Cecília
2 Aldehydes and ketones; structure, physical, chemical properties, reactions, important representatives. Dr. Pápayné Dr. Sár Cecília
3 Aldehydes and ketones; structure, physical, chemical properties, reactions, important representatives. Dr. Pápayné Dr. Sár Cecília
4 Carboxylic acids and their derivatives – structure, physical, chemical properties. Dr. Hideg Kálmán
5
Dr. Hideg Kálmán 6
Dr. Hideg Kálmán
7 alpha-Position substituted derivatives of carboxylic acids Dr. Hideg Kálmán
8
Dr. Hideg Kálmán 9
Dr. Hideg Kálmán
10 Di- and polycarboxylic acids, representatives Dr. Hideg Kálmán
11
Dr. Hideg Kálmán 12
Dr. Hideg Kálmán
13 Carbonic acid derivatives and their importance in biology and drugs Dr. Hideg Kálmán
14
15
Dr. Hideg Kálmán
16 Esters of inorganic acids, biological significance (phosphatides, phospholipids). Dr. Hideg Kálmán
17
Dr. Hideg Kálmán 18
Dr. Hideg Kálmán
19 alpha-Amino acids, peptides and proteins, biological importance Dr. Hideg Kálmán
20
Dr. Hideg Kálmán 21
Dr. Hideg Kálmán
22 Monosaccharides; structure, mutarotation, reactions and biological importance Dr. Pápayné Dr. Sár Cecília
23 Monosaccharides; structure, mutarotation, reactions and biological importance Dr. Pápayné Dr. Sár Cecília
24 Monosaccharides; structure, mutarotation, reactions and biological importance Dr. Pápayné Dr. Sár Cecília
25 Di- and polysaccharides; food reserve and structural material polysaccharides. Dr. Pápayné Dr. Sár Cecília
26 Di- and polysaccharides; food reserve and structural material polysaccharides. Dr. Pápayné Dr. Sár Cecília
27 Di- and polysaccharides; food reserve and structural material polysaccharides. Dr. Pápayné Dr. Sár Cecília
28 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
29 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
30 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
31 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
32 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
33 Heterocycles (5- and 6-membered heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes)
Dr. Kálai Tamás
34 Heterocycles in nucleotides, nucleosides, nucleic acids
Dr. Kálai Tamás
35 Heterocycles in nucleotides, nucleosides, nucleic acids
Dr. Kálai Tamás
36 Heterocycles in nucleotides, nucleosides, nucleic acids
Dr. Kálai Tamás 37 Vitamins Dr. Hideg Kálmán 38 Dr. Hideg Kálmán 39 Dr. Hideg Kálmán
40 The basics of spectrometric identification of organic compounds Dr. Hideg Kálmán 41 Dr. Hideg Kálmán 42 Dr. Hideg Kálmán Practices
1 General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin. 2 General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin. 3 General instructions for work in the laboratory, safety precautions; Purification of benzaldehyde, synthesis of benzoin. 4 Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds.
5 Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds. 6 Synthesis of 2,6-dibenzylidene-cyclohexanone; Characteristic tube reactions of oxo compounds. 7 Synthesis of benzil; Identification of 4th unknown compound.
8 Synthesis of benzil; Identification of 4th unknown compound. 9 Synthesis of benzil; Identification of 4th unknown compound.
10 Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid and pectin. 11 Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid and pectin. 12 Characteristic tube reactions of carbohydrates; Preparation of oxalic acid, isolation of citric acid and pectin. 13 Acetylation of glucose; Identification of 5th unknown compound;
14 Acetylation of glucose; Identification of 5th unknown compound; 15 Acetylation of glucose; Identification of 5th unknown compound;
16 1st written test; Characteristic tube reactions of carboxylic acids; Synthesis of aspirin.
17 1st written test; Characteristic tube reactions of carboxylic acids; Synthesis of aspirin.
18 1st written test; Characteristic tube reactions of carboxylic acids; Synthesis of aspirin.
19 Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acid derivatives
20 Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acid derivatives 21 Synthesis of lidocain (1st step); Characteristic tube reactions of carboxylic acid derivatives 22 Synthesis of lidocain (2nd step)
23 Synthesis of lidocain (2nd step) 24 Synthesis of lidocain (2nd step)
25 Synthesis of heterocycles I.: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles 26 Synthesis of heterocycles I.: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles 27 Synthesis of heterocycles I.: benzimidazole, 4,5-diphenyl-imidazole; Characteristic tube reactions of heterocycles 28 Synthesis of heterocycles II.: dilantin, 4-methyl-7-hydroxycoumarine
29 Synthesis of heterocycles II.: dilantin, 4-methyl-7-hydroxycoumarine 30 Synthesis of heterocycles II.: dilantin, 4-methyl-7-hydroxycoumarine 31 2nd written test. Isolation of caffeine
32 2nd written test. Isolation of caffeine 33 2nd written test. Isolation of caffeine 34 Isolation of quercetin and myristic acid 35 Isolation of quercetin and myristic acid 36 Isolation of quercetin and myristic acid
37 Characteristic tube reactions of amino acids and peptides 38 Characteristic tube reactions of amino acids and peptides 39 Characteristic tube reactions of amino acids and peptides 40 Evaluation
41 Evaluation 42 Evaluation
Exam topics/questions
1. Alkanes: Orbital hybridization and the structure of alkanes; Nomenclature, physical and chemical properties, conformation.
2. Alkyl, aryl halides: the character of C-X bonds, synthesis and reactions of alkyl halides (substitution, elimination); Organic halides in the environment.
3. Unsaturated hydrocarbons: sp2 and sp hybridization, nomenclature, physical properties, reactions and synthesis of alkenes and alkynes.
4. Importance of unsaturated hydrocarbons in industry and biology: polymerization, isoprene, terpenes, steroids, carotenoids. 5. Aromatic compounds: the structure of benzene, Hückel-rule. Electrophilic aromatic substitution reactions.
6. 5-membered heterocycles, heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes).
7. 6-membered heterocycles, heteroaromatic compounds, structure, biologically important representatives, chemical mode of action of coenzymes).
8. Alcohols, phenols, ethers: Structure, physical and chemical properties, reactions; Their biological importance.
9. Oxo-compondsnes – structure, physical, chemical properties, reactions, enol-oxo tautomerism, important representatives. 10. Carboxylic acids – structure, physical, chemical properties.
11. Alpha-Position substituted derivatives of carboxylic acids, di- and polycarboxylic acids, representatives. 12. Carboxylic acid derivatives – structure, physical, chemical properties.
13. Carbonic acid derivatives and their importance in biology and drugs. 14. Alpha-Amino acids, peptides and proteins, biological importance.
15. Esters of inorganic acids, biological significance (phosphatides, phospholipids).
16. Organometallic compounds: their importance in organic syntheses (Mg, Na, Li, Zn, Si, Cu, Cd compounds).
17. Sulfur containing compounds: Physical, chemical properties, importance in biological processes (in amino acids, peptides, methylation in biology, AcCo-A, drugs).
18. Aliphatic and aromatic nitro, azo and diazo compounds: Structure, reactions, significance in organic syntheses. 19. Amines: nomenclature, physical and chemical properties, basicity, preparation.
20. Biologically active amines: Alkaloids, nitrogen containing drugs and hormones. 21. Monosaccharides: structure, mutarotation, reactions and biological importance. 22. Di- and polysaccharides: food reserve and structural material polysaccharides. 23. Heterocycles in nucleotides, nucleosides, nucleic acids.
24. Stereochemistry: isomerism, configuration, chirality.
Participants