1. INTRODUCCIÓN
1.3. Evaluación de la calidad de vida relacionada con la salud en asma y EPOC
Our study on haplotype/phenotype correlation has shown the existence of at least 11 different haplotype combinations in Oman. These are differently distributed among the six main regions of the country. Sub-haplotype was only observed in CAR/OmanI combination and could be associated with the clinical differences observed in patients with the same haplotype. Identifying haplotypes and sub-haplotypes in early life may allow a better prognosis and a more accurate risk predictions and a better tailored therapy, to match disease-related risks and to facilitate planning of clinical trials to prevent the development of severe complications later in life. nevertheless, we have shown that when the phenotypes are classified into; mild, intermediate and severe, neither the haplotype or the HbF alone appeared to be fully associable with the clinical phenotypes as also been observed by Alexander et al (29). External and/or modifying, or epistatic factors, which potentially modulate the phenotype of SCD do occur and more efforts should be done trying to chart them. The implementation of primary prevention with simple cost effective interventions for SCD are essential (30) and are likely to lead to lower incidence, lower costs for public health and improved survival rate of SCD patients in Oman.
ACKNOWLEDGEMENTS
The authors declare to have conducted this study according to local ethical regulations and to have no conflicts of interest on the presented matters.
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