Evaluación General por telar

GOLD IV: triangles

Green: low levels of ROS

Red: high levels of ROS

Purple: high levels of ROS during the recovery period

500 1000 Mitochondrial Vmax, ml/min: 2000 3000

Predictive Medicine for Chronic Patients in an Integrated Care Scenario 157





Figure 7: Relationships between estimated average muscle maximum O2 transport (VO2), y-

axis; and, estimated average muscle cellular oxygenation (PmO2), x-axis, in COPD patients

and healthy subjects. The different symbols correspond to classical GOLD stages: squares, GOLD II; circles GOLD III; and, triangles, GOLD IV. The colors correspond to the percent of exercising muscle estimated to generate abnormally high mitochondrial ROS generation: green (0%), yellow (0% - 24.9%), orange (25% - 49.9%), red (50% - 74.9%), and violet (75% - 100%). The symbol size correspond to the subject measured body mass index (BMI): big symbols indicate subjects with normal BMI (>21 kg/m2_{) while small symbols indicate subjects}

with low BMI (≤ 21 kg/m2_).

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Figure 8: Estimated percent of exercising muscle predicted to generate abnormally high

mitochondrial ROS generation (upper panel), estimated overall exercising muscle oxygenation (middle panel), and estimations for overall VO2max (lower panel). Simulation results for

healthy subjects (C1-C9), COPD patients with normal body mass index (BMI) (N1-N12), and COPD patients with low BMI (L1-L6 both before and after a training period of 8 weeks.

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Figure 9: Left-hand panel (a) shows that % of skeletal muscle (i.e. Vmax) producing high

levels of ROS production for different disease groups (COPDN and COPDL denote COPD patients with normal and low Fat Free Mass Index respectively) and conditions (BT (Before training), AT (After training and D (After minus Before Training Difference)) is correlated with clinical measurements. In each comparison, the Pearson Correlation was computed, and the coefficient is provided in a percentage style. In the right-hand panel (b) Bonferroni-Adjusted P-values (in a percentage style) are shown. The MDA_Serum vs. %Vmax explained by ROS is the only bivariate that significantly correlates when the difference after and before training is considered (adjusted p-value <0.05).



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