In conclusion, we demonstrated that transplantation of adult human EPDCs into the infarcted heart improved cardiac performance by preventing additional loss already at day 2 after MI, which was instigated through early paracrine signaling. It was strongly suggested that accelerated generation of new murine EPDCs from the host epicardium contributed to the functional profit, since i) it was demonstrated that host epicardium could form new EPDCs, and ii) WT1 expression, highly associated with EMT and EPDC formation, was only expressed in EPDC-recipients at day 2 (as opposed to day 4 in the control group).
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1 Dept. of Anatomy & Embryology, 2 Dept. of Molecular Cell Biology, 3 Dept. of Cardiology, Leiden University Medical
Winter EM1, van Oorschot AAM2, Hogers B1, van der Graaf LM1, Doevendans P4, Poelmann RE1,
Atsma DE3, Gittenberger-de Groot AC1 * , Goumans MJ2 *