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INFLUENCIA DE LAS VARIACIONES CLIMÁTICAS EN LA RECARGA SUBTERRÁNEA EN LA REGIÓN COSTERA DE LA PROVINCIA DE BUENOS AIRES

411 Figura 5 Temperatura mínima anual media

INFLUENCIA DE LAS VARIACIONES CLIMÁTICAS EN LA RECARGA SUBTERRÁNEA EN LA REGIÓN COSTERA DE LA PROVINCIA DE BUENOS AIRES

a) Delta band

For delta band two-way repeated measure ANOVA (group x time) depicted a significant effect of time, significant effect of group as well as a significant interaction effect. Post-hoc test for main effect of time revealed that during-ictal/non-ictal interval had a stronger source power compared to pre- and post-ictal/non-ictal intervals. The significant source maximum for during vs. pre interval and during vs. post interval was observed in the Rectus R,L region. For the effect of group it was seen that the source power for ictal GSWDs was stronger compared to non-ictal GSWDs. The source maximum, for the significant difference between ictal vs. non-ictal group was also seen in the Rectus R. Further, post hoc tests for interaction effect depicted, that the source power transition from pre interval to during interval and from during interval to post interval is stronger for ictal GSWDs is stronger compared to the transition periods of non-ictal GSWDs. The source maximum for the significant difference of

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during-pre (ictal/non-ictal) and post-during (ictal/non-ictal) was observed in the Rectus region again. Neighbouring sources were seen in the regions of Frontal superior R, Frontal Inferior orb R, Para-hippocampal R,L, Olfactory L, and Frontal medial orb R.

Figure A.1: Delta band time effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for conditions during vs. pre interval and during vs. post interval, indicating the source maximum.

Figure A.2: Delta band group effect. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the condition ictal vs. non-ictal, indicating the source maximum

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Figure A.3: Delta band interaction effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the conditions ictal vs. non-ictal (during-pre) and ictal vs. non-ictal (during-post), indicating the source maximum.

b) Theta Band

For theta band two-way repeated measure ANOVA, only demonstrated a significant effect of time. A significant group effect and interaction effect was not found.

Figure A.4: Theta band time effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for conditions during vs. pre interval and during vs. post interval, indicating the source maximum.

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Post hoc tests for the main effect of time depicted that during-ictal/non-ictal interval had a stronger source power compared to pre- and post-ictal/non-ictal intervals. The significant source maximum for during vs. pre interval and for during vs. post interval was observed in the Rectus R,L region. Whereas, neighbouring sources were found in the Frontal superior orb R, Frontal Inferior orb R, region.

c) Alpha band

Two-way repeated measure ANOVA, depicted a significant effect of time, significant effect of group and a significant interaction effect.

Post-hoc test for main effect of time revealed that during-ictal/non-ictal interval for alpha band frequency had a stronger source power compared to pre- and post-ictal/non-ictal intervals. The significant source maximum for during vs. pre interval and during vs. post interval was observed in the Rectus R,L region. The neighbouring sources were found in the regions of Frontal mid orb R, Frontal Inferior tri R, and Frontal Inferior orb R, L.For the effect of group it was seen that the source power for ictal GSWDs was stronger compared to non-ictal GSWDs. The source maximum, for the significant difference between ictal vs. non- ictal group was seen in the Rectus, with neighbouring source maximum points being in Frontal inferior orb L, Temporal pole superior L, Amygdala L, R, Caudate R, region.

Figure A.5: Alpha band time effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for conditions during vs. pre interval and during vs. post interval, indicating the source maximum.

Post hoc tests for interaction effect revealed that the source power transition from pre interval to during interval, and from during interval to post interval was stronger for ictal GSWDs is stronger, compared to the transition periods of non-ictal GSWDs. The source maximum for the significant difference of during-pre (ictal/non-ictal) and post-during (ictal/non-ictal) was

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observed in the Rectus R,L, followed by neighbouring sources in the Frontal inferior orb L, Insula L, Temporal pole superior L, Hippocampus L, Amygdala L, Para-hippocampal L region.

Figure A1.6: Alpha band group effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the condition ictal vs. non-ictal, indicating the source maximum.

Figure A.7: Alpha band interaction effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the conditions ictal vs. non-ictal (during-pre) and ictal vs. non-ictal (during-post), indicating the source maximum.

150 d) Beta band

Two-way repeated measure ANOVA for beta band depicted a significant effect of time, significant effect of group and a significant interaction effect.

Post-hoc test for main effect of time revealed that during-ictal/non-ictal interval for beta band frequency had a stronger source power compared to pre- and post-ictal/non-ictal intervals. The significant source maximum for during vs. pre interval and during vs. post interval was observed in the Frontal superior medial R, region.

For the effect of group it was seen that the source power for ictal GSWDs was stronger compared to non-ictal GSWDs. The source maximum, for the significant difference between ictal vs. non-ictal group was seen in Frontal superior medial R, and Cingulum anterior R, region.

Post hoc tests for interaction effect revealed, that the source power transition from pre interval to during interval and from during interval to post interval wass stronger for ictal GSWDs is stronger compared to the transition periods of non-ictal GSWDs. The source maximum for the significant difference of during-pre (ictal/non-ictal) was in the Frontal medial orb L, R, and Cingulum anterior region. For post-during (ictal/non-ictal), the source maximum was seen in Frontal medial orb L, R region.

Figure A.8: Beta band time effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for conditions during vs. pre interval and during vs. post interval, indicating the source maximum.

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Figure A.9: Beta band group effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the condition ictal vs. non-ictal, indicating the source maximum.

Figure A.10: Beta band interaction effect for non-normalized data. a) Two way ANOVA results depicting the F-value b) Post-hoc test results for the conditions ictal vs. non-ictal (during-pre) and ictal vs. non-ictal (during-post), indicating the source maximum.

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Conditions Frequency Bands

Delta Theta Alpha Beta

Effect of time

during vs. pre 0.001 0.001 0.001 0.001

during vs. post 0.001 0.001 0.001 0.001

Effect of group

ictal vs. non-ictal 0.002 No significance 0.001 0.01

Interaction effect ictal vs. non-ictal (during-pre) 0.002 No significance 0.002 0.01 ictal vs. non-ictal (during-post) 0.006 No significance 0.001 0.005

Table A.2: Depiction of p-values for all frequency bands and for each condition, done for non-normalized data.

A.1.3 Comparison of source analysis for normalized data vs. non-