La interacción multiplicador-acelerador y los modelos keynesianos del ciclo económico

The authors thank B. Schumann (American Angus Association), C. Hines (Ohio State); S. Schmutz (University of Alberta); Dr. Z. Hu, J. Collins, J. Frerichs, A. Moe, B. Mote, P. Zaback and J.R. Tait (Iowa State University); Dr. C. Charlier, Dr. H. Takeda, and N. Tama (University of Liege, Liege, Belgium); Drs. J. Cavanagh and I. Tammen (University of Sydney, Camden, NSW, Australia); Dr.T. Aboellail (Washington State University) for technical advice and veterinary diagnostic examination. Dr. Benoit de Crombrugghe (Texas Southwest Medical Center) kindly provided a SOX9 expression vector.

REFERENCES

1. McCann, L.P., The Battle of the Bull Runts. 1 ed. 1974, Columbus, OH: L.P. McCann. 176.

2. Naski, M.C., et al., Graded activation of fibroblast growth factor receptor 3 by

mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet,

1996. 13(2): p. 233-7.

3. Harper, P.A., et al., Chondrodysplasia in Australian Dexter cattle. Aust Vet J, 1998. 76(3): p. 199-202.

4. Takeda, H., et al., Positional cloning of the gene LIMBIN responsible for

bovine chondrodysplastic dwarfism. Proc Natl Acad Sci U S A, 2002. 99(16):

p. 10549-54.

5. Mishra, B.P. and J.M. Reecy, Mutations in the limbin gene previously associated with dwarfism in Japanese brown cattle are not responsible for

dwarfism in the American Angus breed. Anim Genet, 2003. 34(4): p. 311-2.

6. The USDA MARC website database for bovine genomic marker positions.

August 16, 2004 [cited; Available from: http://www.marc.usda.gov/genome/genome.html

7. Fernandez, S.A., et al., Irreducibility and efficiency of ESIP to sample marker

genotypes in large pedigrees with loops. Genet Sel Evol, 2002. 34(5): p. 537-

55.

8. Fernandez, S.A., et al., Sampling genotypes in large pedigrees with loops. Genet Sel Evol, 2001. 33(4): p. 337-67.

9. Cannings, C., E.A. Thompson, and M.H. Skolnick, Probability Functions on

Complex Pedigrees. Adv. Appl. Prob., 1978. 10: p. 26-61.

10. Elston, R.C. and J. Stewart, A general model for the genetic analysis of

pedigree data. Hum Hered, 1971. 21(6): p. 523-42.

11. Ott, J., Estimation of the recombination fraction in human pedigrees: efficient

computation of the likelihood for human linkage studies. Am J Hum Genet,

1974. 26(5): p. 588-97.

12. Altschul, S.F., et al., Basic local alignment search tool. J Mol Biol, 1990. 215(3): p. 403-10.

13. Altschul, S.F., et al., Gapped BLAST and PSI-BLAST: a new generation of

protein database search programs. Nucleic Acids Res, 1997. 25(17): p. 3389-

402.

14. ENSEMBL. A genomic database including gene sequence for a multitude of

organisms. December, 2 2004 [cited; Available from:

http://www.ensembl.org/index.html.

15. The UCSC golden path genome browser and gene database. December 2,

2004 [cited; Available from: http://www.genome.ucsc.edu/

16. Primer 3, an online tool for Primer oligonucleotide design for PCR. December

10, 2004 [cited; Available from: http://frodo.wi.mit.edu/cgi- bin/primer3/primer3_www.cgi

17. Livak, K.J. and T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 2001. 25(4): p. 402-8.

18. Everts-van der Wind, A., et al., A high-resolution whole-genome cattle-human

comparative map reveals details of mammalian chromosome evolution. Proc

Natl Acad Sci U S A, 2005. 102(51): p. 18526-31.

19. Guex, N. and M.C. Peitsch, SWISS-MODEL and the Swiss-PdbViewer: an

environment for comparative protein modeling. Electrophoresis, 1997. 18(15):

p. 2714-23.

20. Schwede, T., et al., SWISS-MODEL: An automated protein homology-

modeling server. Nucleic Acids Res, 2003. 31(13): p. 3381-5.

21. Delano, W.L. The PyMOL Molecular Graphics System. 2002 [cited; Available from: http://www.pymol.org.

22. Chikuda, H., et al., Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Genes Dev, 2004. 18(19): p. 2418-29.

23. Pfeifer, A., et al., Intestinal secretory defects and dwarfism in mice lacking

cGMP-dependent protein kinase II. Science, 1996. 274(5295): p. 2082-6.

24. Bovine QTL database as maintained by Texas A&M University. December

25. A bovine QTL database of dairy traits as maintained by the Univeristy of

Sydeny, Sydeny, Australia. December 2006 [cited; Available from:

http://www.vetsci.usyd.edu.au/reprogen/QTL_Map/

26. The Animal QTL db. A QTL database maintained by Iowa State University

through the USDA NRSP-8 bioinformatics project. January 2007 [cited;

Available from: http://www.animalgenome.org/QTLdb/cattle.html.

27. Hofmann, F., et al., Function of cGMP-dependent protein kinases as revealed

by gene deletion. Physiol Rev, 2006. 86(1): p. 1-23.

28. Vaandrager, A.B., B.M. Hogema, and H.R. de Jonge, Molecular properties

and biological functions of cGMP-dependent protein kinase II. Front Biosci,

2005. 10: p. 2150-64.

29. Vaandrager, A.B., A.G. Bot, and H.R. De Jonge, Guanosine 3',5'-cyclic monophosphate-dependent protein kinase II mediates heat-stable

enterotoxin-provoked chloride secretion in rat intestine. Gastroenterology,

1997. 112(2): p. 437-43.

30. Vaandrager, A.B., et al., Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon. Gastroenterology, 2000. 118(1): p. 108-14.

31. The Paul Alan brain atlas. A database cataloguing all gene and protein

expression in the brain with histological data and images made freely

available on the world wide web. February 10, 2007 [cited; Available from:

http://www.brain-map.org/.

32. El-Husseini, A.E., et al., Nitric oxide regulates cyclic GMP-dependent protein

kinase phosphorylation in rat brain. J Neurochem, 1998. 71(2): p. 676-83.

33. Oster, H., et al., cGMP-dependent protein kinase II modulates mPer1 and

mPer2 gene induction and influences phase shifts of the circadian clock. Curr

Biol, 2003. 13(9): p. 725-33.

34. Scherer-Oppliger, T., et al., Serine 19 of human 6-pyruvoyltetrahydropterin

synthase is phosphorylated by cGMP protein kinase II. J Biol Chem, 1999.

274(44): p. 31341-8.

35. Werner, C., et al., Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of

36. McCarty, M.F., cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in

prevention/treatment of diabetes. Med Hypotheses, 2006. 66(2): p. 323-8.

37. NEB Cutter, an online tool to find RFLP sites in nucleic acid sequence. June

2005 [cited; Available from: http://www.neb.com/nebecomm/products/category1.asp?#2