4. CONSIDERACIONES SOBRE ADQUISICIÓN Y DESARROLLO DEL LENGUAJE
4.3 RAÍCES GENÉTICAS DEL PENSAMIENTO Y EL LENGUAJE
4.3.1 Lenguaje interiorizado
Climbing fibre activation produces a large EPSP that spreads throughout the dendritic tree of the Purkinje neuron. At depolarised membrane potentials secondary dendritic calcium spikes follow the EPSP. Secondary dendritic calcium spikes develop with a time course consistent with its mediation by facilitation of calcium channels. When elicited locally by pairing with depolarisation from parallel fibre input, the secondary spikes appear to be specific the branch where they are being elicited. Local inhibition may further localise the localisation of secondary spikes. This provides a secondary messenger system with properties similar to those expected of a trigger for synaptic plasticity.
Future directions would be to quantitatively map out the spread of secondary spikes elicited by the pairing of PF and C F input. It should be established whether or not the spatial spread of LTD is matched by the spread of dendritic secondary spikes. Both these questions should probably await the development of good voltage sensitive dyes before being attempted. Lastly, it should be established, perhaps with a mixture of cell attached recordings and
Chapter 6: G eneral discussion 140
molecular biology, whether or not facilitation of calcium channels underlies the development of secondary spikes in time.
141
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