Marco teórico

It has only been in the last 150 years that scientists started to think about how genetic information is passed down through the generations. At the beginning, scientists were thinking about the large-scale questions – what is inheritance? What is evolution? This type of thinking certainly pushed our thinking forward, but it is only recently that we have developed the tools and technology necessary to get at the molecular basis for these

mechanisms. The work presented in this thesis addresses a molecular mechanism that is on the scale of 5 Å – much smaller than peas or finches. And while DNA sequence was one of the first centromeric features characterized, we are only now beginning to understand its role at the centromere and in meiotic drive. By honing in on the fine details of centromeres, we can better understand how cell division, and thus the basis for inheritance and evolution, functions. It is only in studying these smaller details that we will truly be able to understand the largest scientific phenomena.

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