• No se han encontrado resultados

2.10 División del mercado

4.5.7 Medios alternativos

1 National Patient Safety Agency (NPSA). (National Confidential Enquiry into Patient Outcome and Death (NCEPOD), 2005).

2 Wachter, R. Understanding Patient Safety. (McGraw-Hill Education / Medical, 2012).

3 Levinson, D. Adverse events in hospitals: national incidence among medicare beneficiaries. Report No. OEI-06-09-00090, (2010).

4 Knowing the Risk A review of the peri-operative care of surgical patients. (National Confidential Enquiry into Patient Outcome and Death, 2011).

5 Adding Insult to Injury: a Review of the Care of Patients who Died in Hospital with a Primary Diagnosis of Acute Kidney Injury (acute renal failure). (National Confidential Enquiry into Patient Outcome and Death, 2009).

6 Centre, N. C. G. Intravenous Fluid Therapy- Intravenous fluid therapy in adults in hospital. Report No. CG174, (National Institute for Health and Care Excellence, 2013).

7 NIfHaC, E. NICE clinical guideline 50 Acutely ill patients in hospital: recognition of and response to acute illness in adults in hospital. London: National Institute for Health and Clinical Excellence (2007).

8 An Acute Problem ? , (National Confidential Enquiry into Patient Outcome and Death, 2005). 9 Martin, I. C. et al.Emergency Admissions: A Journey in the Right Direction? , (NCEPOD, 2007). 10 Caring to the End? A review of the care of patients who died in hospital within four days of

admissions. (2009).

11 Time to Intervene? A review of patients who underwent cardiopulmonary resuscitation as a result of in-hospital cardiorespiratory arrest. (National Confidential Enquiry into Patient Outcome and Death, 2012).

12 Just Say Sepsis! A review of the process of care received by patients with sepsis. (National Confidential Enquiry into Patient Outcome and Death, 2015).

13 Federal Register Volume 68. 68 FR 3454 (U.S. Government Publishing Office, 2003). <https://www.gpo.gov/fdsys/pkg/FR-2003-01-24/content-detail.html>

14 Commissioning for Quality and Innovation (CQUIN), <https://www.england.nhs.uk/nhs- standard-contract/cquin/> (

15 Smith, G. B. In-hospital cardiac arrest: is it time for an in-hospital 'chain of prevention'? Resuscitation81, 1209-1211, doi:10.1016/j.resuscitation.2010.04.017 ( 2010).

16 Jones, D. A., DeVita, M. A. & Bellomo, R. Rapid-response teams. N Engl J Med365, 139-146, doi:10.1056/NEJMra0910926 (2011).

17 National Early Warning Score (NEWS) Standardising the assessment acute illness severity in the NHS. (Royal College of Physicians, 2012).

18 (ed Department of Health) (2013).

19 Gardner-Thorpe, J., Love, N., Wrightson, J., Walsh, S. & Keeling, N. The value of Modified Early Warning Score (MEWS) in surgical in-patients: a prospective observational study. Ann R Coll Surg Engl88, 571-575, doi:10.1308/003588406X130615 (2006).

20 Smith, G. B., Prytherch, D. R., Schmidt, P. E., Featherstone, P. I. & Higgins, B. A review, and performance evaluation, of single-parameter "track and trigger" systems. Resuscitation79, 11- 21, doi:10.1016/j.resuscitation.2008.05.004 ( 2008).

21 Smith, G. B., Prytherch, D. R., Schmidt, P. E. & Featherstone, P. I. Review and performance evaluation of aggregate weighted 'track and trigger' systems. Resuscitation 77, 170-179, doi:10.1016/j.resuscitation.2007.12.004 ( 2008).

22 Salamonson, Y., Kariyawasam, A., van Heere, B. & O'Connor, C. The evolutionary process of Medical Emergency Team (MET) implementation: reduction in unanticipated ICU transfers. Resuscitation49, 135-141 (2001).

23 Harrison, G. A., Jacques, T. C., Kilborn, G. & McLaws, M. L. The prevalence of recordings of the signs of critical conditions and emergency responses in hospital wards--the SOCCER study. Resuscitation65, 149-157, doi:10.1016/j.resuscitation.2004.11.017 (2005).

24 Smith, G. B., Prytherch, D. R., Meredith, P., Schmidt, P. E. & Featherstone, P. I. The ability of the National Early Warning Score (NEWS) to discriminate patients at risk of early cardiac arrest, unanticipated intensive care unit admission, and death. Resuscitation 84, 465-470, doi:10.1016/j.resuscitation.2012.12.016 (2013).

25 Bleyer, A. J. et al. Longitudinal analysis of one million vital signs in patients in an academic medical center. Resuscitation, doi:10.1016/j.resuscitation.2011.06.033 (2011).

26 Romero-Brufau, S. et al. Widely used track and trigger scores: are they ready for automation in practice? Resuscitation85, 549-552, doi:10.1016/j.resuscitation.2013.12.017 (2014). 27 Ranson, J. H. et al. Prognostic signs and the role of operative management in acute

pancreatitis. Surg Gynecol Obstet139, 69-81 (1974).

28 Ozarda, Y. Reference intervals: current status, recent developments and future considerations. Biochem Med (Zagreb)26, 5-16, doi:10.11613/BM.2016.001 (2016).

29 Grasbeck, R. & Fellman, J. Normal values and statistics. Scand J Clin Lab Invest21, 193-195 (1968).

30 Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline—Third Edition C28-A3c EP28-A3c* 3/16/2012. Clinical and Laboratory Standards Institute, Wayne, PA, USA

31 Asadollahi, K., Hastings, I. M., Gill, G. V. & Beeching, N. J. Prediction of hospital mortality from admission laboratory data and patient age: a simple model. Emerg Med Australas23, 354-363, doi:10.1111/j.1742-6723.2011.01410.x (2011).

32 Loekito, E. et al. Common laboratory tests predict imminent medical emergency team calls, intensive care unit admission or death in emergency department patients. Emerg Med Australas25, 132-139, doi:10.1111/1742-6723.12040 (2013).

33 Weinberg, A. D. & Minaker, K. L. Dehydration. Evaluation and management in older adults. Council on Scientific Affairs, American Medical Association. JAMA274, 1552-1556 ( 1995). 34 Hooper, L., Bunn, D., Jimoh, F. O. & Fairweather-Tait, S. J. Water-loss dehydration and aging.

Mech Ageing Dev, doi:10.1016/j.mad.2013.11.009 (2013).

35 González-Alonso, J., Mora-Rodríguez, R., Below, P. R. & Coyle, E. F. Dehydration reduces cardiac output and increases systemic and cutaneous vascular resistance during exercise. J Appl Physiol (1985)79, 1487-1496 (1995).

36 Popkin, B. M., D'Anci, K. E. & Rosenberg, I. H. Water, hydration, and health. Nutr Rev68, 439- 458, doi:10.1111/j.1753-4887.2010.00304.x (2010).

37 Kelly, J. et al. Dehydration and venous thromboembolism after acute stroke. QJM97, 293-296 (2004).

38 Briongos Figuero, S. et al. Dehydration and serum hyperosmolarity as new predictors of mortality after acute coronary syndrome. Int J Cardiol, doi:10.1016/j.ijcard.2014.01.033 (2014).

39 Lin, H.-L. et al. High preoperative ratio of blood urea nitrogen to creatinine increased mortality in gastrointestinal cancer patients who developed postoperative enteric fistulas. Kaohsiung J Med Sci28, 418-422, doi:10.1016/j.kjms.2012.02.011 (2012).

40 Beier, K. et al. Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of "normal" creatinine. Crit Care Med 39, 305-313, doi:10.1097/CCM.0b013e3181ffe22a (2011).

41 Mortensen, P. B., Nohr, M., Moller-Petersen, J. F. & Balslev, I. The diagnostic value of serum urea/creatinine ratio in distinguishing between upper and lower gastrointestinal bleeding. A prospective study. Danish Medical Bulletin41, 237-240 (1994).

42 Witting, M. D. et al. ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis. Am J Emerg Med24, 280-285, doi:10.1016/j.ajem.2005.11.005 (2006).

43 Beaufrere, B. et al. Glucocorticosteroids increase leucine oxidation and impair leucine balance in humans. The American journal of physiology257, E712-721 (1989).

44 Combe, C. et al. Influence of nutritional factors and hemodialysis adequacy on the survival of 1,610 French patients. Am J Kidney Dis37, S81-88 (2001).

45 Cartin-Ceba, R., Afessa, B. & Gajic, O. Low baseline serum creatinine concentration predicts mortality in critically ill patients independent of body mass index. Crit Care Med35, 2420-2423 (2007).

46 Lieberman, H. R. Hydration and cognition: a critical review and recommendations for future research. J Am Coll Nutr26, 555S-561S (2007).

47 Maughan, R. J. Impact of mild dehydration on wellness and on exercise performance. Eur J Clin Nutr57 Suppl 2, S19-23, doi:10.1038/sj.ejcn.1601897 (2003).

48 Armstrong, L. E. et al. Mild dehydration affects mood in healthy young women. J Nutr142, 382-388, doi:10.3945/jn.111.142000 (2012).

49 Maughan, R. J. Hydration, morbidity, and mortality in vulnerable populations. Nutr Rev 70 Suppl 2, S152-155, doi:10.1111/j.1753-4887.2012.00531.x (2012).

50 Murray, B. Hydration and physical performance. J Am Coll Nutr26, 542S-548S (2007).

51 Namdar, T. et al. Impact of hypernatremia on burn wound healing: results of an exploratory, retrospective study. Ostomy Wound Manage57, 30-34 (2011).

52 Kateros, K. et al. Analysis of kidney dysfunction in orthopaedic patients. BMC Nephrol13, 101, doi:10.1186/1471-2369-13-101 (2012).

53 Uchino, S., Bellomo, R. & Goldsmith, D. The meaning of the blood urea nitrogen/creatinine ratio in acute kidney injury. Clinical Kidney Journal5, 187-191, doi:10.1093/ckj/sfs013 (2012). 54 Oksa, H., Pasternack, A. & Pasanen, M. Serum urea-creatinine ratio as a prognostic index in

hemodialysis patients. Clinical Nephrology27, 125-130 (1987).

55 De Lima, J. J., da Fonseca, J. A. & Godoy, A. D. Baseline variables associated with early death and extended survival on dialysis. Renal Failure20, 581-587 (1998).

56 Lin, L. C. et al. Predictors of early clinical deterioration after acute ischemic stroke. Am J Emerg Med29, 577-581, doi:10.1016/j.ajem.2009.12.019 (2011).

57 Schrock, J. W., Glasenapp, M. & Drogell, K. Elevated blood urea nitrogen/creatinine ratio is associated with poor outcome in patients with ischemic stroke. Clin Neurol Neurosurg114, 881-884, doi:10.1016/j.clineuro.2012.01.031 (2012).

58 Rowat, A., Graham, C. & Dennis, M. Dehydration in hospital-admitted stroke patients: detection, frequency, and association. Stroke 43, 857-859, doi:10.1161/STROKEAHA.111.640821 (2012).

59 Feinfeld, D. A., Bargouthi, H., Niaz, Q. & Carvounis, C. P. Massive and disproportionate elevation of blood urea nitrogen in acute azotemia. International urology and nephrology34, 143-145 (2002).

60 Gotsman, I. et al. The significance of serum urea and renal function in patients with heart failure. Medicine89, 197-203 (2010).

61 Aronson, D. et al. Serum blood urea nitrogen and long-term mortality in acute ST-elevation myocardial infarction. International Journal of Cardiology127, 380-385 (2008).

62 Stookey, J. D., Pieper, C. F. & Cohen, H. J. Is the prevalence of dehydration among community- dwelling older adults really low? Informing current debate over the fluid recommendation for adults aged 70+years. Public Health Nutrition8, 1275-1285 (2005).

63 Mukand, J. A., Cai, C., Zielinski, A., Danish, M. & Berman, J. The effects of dehydration on rehabilitation outcomes of elderly orthopedic patients. Arch Phys Med Rehabil 84, 58-61, doi:10.1053/apmr.2003.50064 (2003).

64 Fine, M. J. et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med336, 243-250, doi:10.1056/NEJM199701233360402 (1997).

65 Lim, W. S. et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax58, 377-382 (2003).

66 Wu, B. U. et al. Blood urea nitrogen in the early assessment of acute pancreatitis: an international validation study. Arch Intern Med 171, 669-676, doi:10.1001/archinternmed.2011.126 (2011).

67 Hartz, A. J., Kuhn, E. M., Kayser, K. L. & Johnson, W. D. BUN as a risk factor for mortality after coronary artery bypass grafting. The Annals of thoracic surgery60, 398-404 (1995).

68 Fonarow, G. C. et al. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA 293, 572-580, doi:10.1001/jama.293.5.572 (2005).

69 Commission, C. Q. Dignity and nutrition inspection programme: national overview. Newcastle upon Tyne: Care Quality Commission (2011).

70 Association, P. Listen to patients, Speak up for change. Harrow: Patients Association (2010). 71 Parliamentary & Ombudsman, H. S. Care and Compassion?: Report of the Health Service

Ombudsman on Ten Investigations Into Nhs Care of Older People. Vol. 778 (The Stationery Office, 2011).

72 Francis, R. Report of the Mid Staffordshire NHS Foundation Trust Public Inquiry: Executive Summary. Vol. 947 (TSO Shop, 2013).

73 Feinmann, J. How hundreds of patients are dying of thirst in hospital: The story of a 22-year- old who died in hospital from dehydration shocked Britain. But his tragedy is horrifyingly common, <http://www.dailymail.co.uk/health/article-2177969/How-hundreds-patients- dying-thirst-hospital-The-story-22-year-old-died-hospital-dehydration-shocked-Britain-But- tragedy-horrifyingly-common.html> (2012).

74 Borland, S. Thousands dying of thirst on NHS: Watchdog forced to issue guidelines on giving patients water, <http://www.dailymail.co.uk/news/article-2403501/Thousands-dying-thirst- NHS-Watchdog-forced-issue-guidelines-giving-patients-water.html> (2013).

75 Hodgekiss, A. 1,000 patients a month are dying in hospital from 'avoidable' kidney problems caused by dehydration, <http://www.dailymail.co.uk/health/article-2609542/1-000-patients- month-dying-hospital-avoidable-kidney-problems-caused-dehydration.html> (2014).

76 Ellicott, C. Patient dying of thirst rang 999: Inquest hears of mother's fury at nurses who neglected son, <http://www.dailymail.co.uk/news/article-2167643/Patient-dying-thirst-rang- 999-Inquest-hears-mothers-fury-nurses-neglected-son.html> (2014).

77 Borland, S. Four elderly patients a week are dying of hunger and thirst 'utterly scandalous' figures reveal, <http://www.dailymail.co.uk/news/article-2516692/Four-elderly-patients- week-dying-hunger-thirst-utterly-scandalous-figures-reveal.html> (2013).

78 (GDG), G. d. g. (ed National Institute for Health and Care Excellence (NICE)) (National Clinical Guideline Centre, http://guidance.nice.org.uk/CG169, 2013).

79 Kerr, M., Bedford, M., Matthews, B. & O'Donoghue, D. The economic impact of acute kidney injury in England. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, doi:10.1093/ndt/gfu016 (2014).

80 England, N. Hospital Episode Statistics, Admitted Patient Care, England - 2012-13 [NS], <http://www.hscic.gov.uk/searchcatalogue?productid=13264&q=title%3a%22Hospital+Episo de+Statistics%2c+Admitted+patient+care+-

+England%22&sort=Relevance&size=10&page=1#top> (2013).

81 Crary, M. A. et al. Dysphagia, nutrition, and hydration in ischemic stroke patients at admission and discharge from acute care. Dysphagia28, 69-76, doi:10.1007/s00455-012-9414-0 (2013). 82 Ftouh, S., Thomas, M. & Acute Kidney Injury Guideline Development, G. Acute kidney injury:

summary of NICE guidance. BMJ347, f4930, doi:10.1136/bmj.f4930 (2013).

83 KDIGO, A. K. I. Work Group: KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl2, 1-138 (2012).

84 Susantitaphong, P. et al. World incidence of AKI: a meta-analysis. Clinical journal of the American Society of Nephrology : CJASN8, 1482-1493, doi:10.2215/CJN.00710113 (2013). 85 Wang, H. E., Muntner, P., Chertow, G. M. & Warnock, D. G. Acute kidney injury and mortality

in hospitalized patients. Am J Nephrol35, 349-355, doi:10.1159/000337487 (2012).

86 Aitken, E. et al. Acute kidney injury: outcomes and quality of care. QJM 106, 323-332, doi:10.1093/qjmed/hcs237 (2013).

87 Metcalfe, W. et al. Acute renal failure requiring renal replacement therapy: incidence and outcome. QJM95, 579-583 (2002).

88 Chawla, L. S., Amdur, R. L., Amodeo, S., Kimmel, P. L. & Palant, C. E. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79, 1361-1369, doi:10.1038/ki.2011.42 (2011).

89 Selby, N. M., Hill, R., Fluck, R. J. & Programme, N. H. S. E. T. K. A. Standardizing the Early Identification of Acute Kidney Injury: The NHS England National Patient Safety Alert. Nephron

131, 113-117, doi:10.1159/000439146 (2015).

90 Moonesinghe, S. R., Mythen, M. G., Das, P., Rowan, K. M. & Grocott, M. P. Risk stratification tools for predicting morbidity and mortality in adult patients undergoing major surgery: qualitative systematic review. Anesthesiology 119, 959-981, doi:10.1097/ALN.0b013e3182a4e94d (2013).

91 Prytherch, D. R. et al. The use of routine laboratory data to predict in-hospital death in medical admissions. Resuscitation66, 203-207, doi:10.1016/j.resuscitation.2005.02.011 ( 2005). 92 Hucker, T. R. et al. Identifying the sick: can biochemical measurements be used to aid decision

making on presentation to the accident and emergency department. Br J Anaesth94, 735-741, doi:10.1093/bja/aei122 (2005).

93 Silke, B., Kellett, J., Rooney, T., Bennett, K. & O'Riordan, D. An improved medical admissions risk system using multivariable fractional polynomial logistic regression modelling. QJM103, 23-32, doi:10.1093/qjmed/hcp149 (2010).

94 Loekito, E. et al. Common laboratory tests predict imminent death in ward patients. Resuscitation, doi:10.1016/j.resuscitation.2012.07.025 (2012).

95 Mohammed, M. A. et al. Which is more useful in predicting hospital mortality--dichotomised blood test results or actual test values? A retrospective study in two hospitals. PLoS One7, e46860, doi:10.1371/journal.pone.0046860 (2012).

96 Jarvis, S. W. et al. Development and validation of a decision tree early warning score based on routine laboratory test results for the discrimination of hospital mortality in emergency medical admissions. Resuscitation 84, 1494-1499, doi:10.1016/j.resuscitation.2013.05.018 (2013).

97 Baxmann, A. C. et al. Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clinical journal of the American Society of Nephrology : CJASN

3, 348-354, doi:10.2215/CJN.02870707 (2008).

98 Kalyani, R. R., Corriere, M. & Ferrucci, L. Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. Lancet Diabetes Endocrinol 2, 819-829, doi:10.1016/S2213-8587(14)70034-8 (2014).

99 Samuel, A. L. Some studies in machine learning using the game of checkers. IBM Journal of research and development3, 210-229 (1959).

100 Mitchell, T. M. Machine learning. 1997. Burr Ridge, IL: McGraw Hill45, 37 (1997). 101 Enlitic, <www.enlitic.com> (2017).

102 Ho, T. K. in Document Analysis and Recognition, 1995., Proceedings of the Third International Conference on. 278-282 (IEEE).

103 Breiman, L. Random forests. Machine learning45, 5-32 (2001). 104 C Click, M. M., V Parmar, H Roark, A Candel. (2016).

105 h2o, <www.h2o.ai>

106 HSCIC. Commissioning Data Sets,

<http://www.datadictionary.nhs.uk/web_site_content/cds_supporting_information/commis sioning_data_sets_overview.asp?shownav=1> (2016).

107 Nouraei, S. et al. A study of clinical coding accuracy in surgery: implications for the use of administrative big data for outcomes management. Annals of surgery261, 1096-1107 (2015). 108 England, N. (ed National Pathology Programme) (NHS England, 2014).

109 Regenstrief Institute, I. Logical Observation Identifiers Names and Codes, <http://loinc.org/background> (2016).

110 HSCIC. National Laboratory Medicine Catalogue (NLMC)

<http://systems.hscic.gov.uk/pathology/projects/nlmc> (2016).

111 McDonald, C. J. et al. LOINC, a universal standard for identifying laboratory observations: a 5- year update. Clinical chemistry49, 624-633 (2003).

112 Association, W. M. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama310, 2191 (2013).

113 Health, D. o. (ed Department of Health) 54 (2005).

114 Authority, H. R. Research requiring NHS review but not ethical review, <http://www.hra.nhs.uk/resources/before-you-apply/research-requiring-nhs-rd-review-but- not-ethical-review/> (

115 Health, D. o. (ed Department of Health) (www.dh.gov.uk, 2011).

116 ICO. (ed Information Commissioner's Office) (https://ico.org.uk/for-organisations/guide-to- data-protection/anonymisation/, 2012).

117 The Caldicott Committee - Chair: Dame Caldicott, F. (ed Department of Health) 137 (http://webarchive.nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/en/Pu blicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_4068403, 1997).

118 Caldicott, F. (ed National Data Guardian) 139

(https://www.gov.uk/government/publications/the-information-governance-review, 2013).

119 Guardian, N. D. (ed Department of Health)

(https://www.gov.uk/government/consultations/the-role-of-the-national-data-guardian-for- health-and-social-care, 2015).

120 Carter, P., Laurie, G. T. & Dixon-Woods, M. The social licence for research: why care. data ran into trouble. Journal of medical ethics, medethics-2014-102374 (2015).

121 NHS Care.data PR Fiasco Continues as Google Pulls Out of Secret Deal, <http://www.infosecurity-magazine.com/news/nhs-caredata-pr-fiasco-continues/> (

122 Martin, A. J. Care.data is a complete omnishambles, says study into hated scheme, <http://www.theregister.co.uk/2015/08/12/caredata_case_study/> (

123 medconfidential.org. The Care.data shambles, <https://medconfidential.org/> (

124 Ingraham, A. M., Cohen, M. E., Raval, M. V., Ko, C. Y. & Nathens, A. B. Comparison of hospital performance in emergency versus elective general surgery operations at 198 hospitals. J Am Coll Surg212, 20-28.e21, doi:10.1016/j.jamcollsurg.2010.09.026 (2011).

125 Commission, C. Q. Annual Health Check Report 2008-09.xlsx, 2009).

126 dr foster intelligence, <http://myhospitalguide.drfosterintelligence.co.uk/#/mortality> (2014).

127 Admission Method: NHS Data Dictionary,

<(http://www.datadictionary.nhs.uk/data_dictionary/attributes/a/add/admission_method_ de.asp)>

128 Yoo, W. et al. A study of effects of multicollinearity in the multivariable analysis. International journal of applied science and technology4, 9 (2014).

129 Jeffreys Interval, <https://en.wikipedia.org/wiki/Binomial_proportion_confidence_interval> ( 130 Porter, C. J. et al. A real-time electronic alert to improve detection of acute kidney injury in a

large teaching hospital. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, doi:10.1093/ndt/gfu082 (2014).

131 Barochia, A. V. et al. Bundled care for septic shock: an analysis of clinical trials. Crit Care Med

38, 668-678, doi:10.1097/CCM.0b013e3181cb0ddf (2010).

132 Westphal, G. A. et al. Reduced mortality after the implementation of a protocol for the early detection of severe sepsis. J Crit Care26, 76-81, doi:10.1016/j.jcrc.2010.08.001 (2011). 133 Pestana, D. et al. Compliance with a sepsis bundle and its effect on intensive care unit mortality

in surgical septic shock patients. J Trauma69, 1282-1287, doi:10.1097/TA.0b013e3181c4539f (2010).

134 Chen, Q. H. et al. [The impact of sepsis bundles on mortality in patients with sepsis shock: a prospective clinical study]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue20, 534-537 (2008).

135 Castellanos-Ortega, A. et al. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-

Documento similar