MODELO ADMINISTRACIÓN EDUCATIVA

ASDs have a strong genetic component, but they have a complex pattern of inheri- tance and are highly heterogeneous. GWASs have not defi ned strong gene candi- dates, leading to the conclusion that multiple rare variants may be involved. Genetic network and integrative genetic approaches are leading to deeper insights into the underlying genetic problems. A number of single-gene disorders, such as fragile X, have been associated with ASDs and may lead the way for the development of new drug therapeutic approaches. The recent discovery of the signifi cant role that CNVs play in ASD and other neurodevelopmental disorders also may help us understand and explain the underlying common genetic networks that are involved. Parental age effects in ASD suggest genetic mechanisms. Prenatal exposure to hurricanes has been associated with autism, pointing to the potential role of environmental stressors. Finally, the exciting role that the ncRNAs may play in regulating brain development and functioning are just beginning to help explain the complex genet- ics of autism.

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Phenotypic

Expression of Autism,