Dipta Sengupta
EDUCATIONAL QUALIFICATIONS Ph.D. in Life Science
National Institute of Technology, Rourkela (2011-2016) with Overall CGPA : 8.79
Master of Science (M.Sc) in Microbiology & Microbial Technology University of Kalyani, Kalyani, West Bengal, 2010
Percentage obtained: 70.14 %, Division: 1st Bachelor Science (B.Sc-Hons.) in Microbiology
University of Kalyani, Kalyani, West Bengal, 2008 Percentage obtained: 56.87%, Division: 2nd
Higher Secondary (10+2)
West Bengal Council of Higher Secondary Education (WBCHSE), 2004 Percentage obtained: 62.9%, Division: 1st
Secondary Education (10)
West Bengal Board of Secondary Education (WBBSE), 2002 Percentage obtained: 70.6%, Division: 1st
RESEARCH EXPERIENCE Ph.D Research Scholar
Title of Thesis: Regulation of chromatin modifier genes by microRNA vis-à-vis regulation of microRNA by DNA methylation and histone modifications in human cancer
Supervised by: Dr. Samir Kumar Patra, Associate Professor Department of Life Science, National Institute of Technology, Rourkela.
Project done at: Department of Life Science, National Institute of Technology, Rourkela.
Duration of project: January 2011 to July 2016 Present Address
Department of Life Science National Institute of Technology Rourkela- 769 008, Orissa, India Phone: 91-661-2464681(O) 91-8673366090 (M) 91-9477358969 (M) Email- [email protected] Permanent Address A-11/557 Kalyani
P.O.–Kalyani, Dist- Nadia.
State- West Bengal, India Pin- 741235
DIPTA SENGUPTA (Ph.D. scholar, Dept. Of Life Science, NIT Rourkela) 2
Summer Trainee
Title: “Isolation of Vibrio cholerae & vibriophages and molecular analysis of
vibriophages”
Supervised by: Dr. B.L.Sarkar., Deputy Director, Vibrio phage reference laboratory,
National Institute of Cholera and Enteric Diseases, (I.C.M.R), Kolkata
Project Completed at: National Institute of Cholera and Enteric Diseases, (I.C.M.R), Kolkata
Duration of project: 2 months (May 2009-June 2009)
Industrial Trainee
Title: “Brewing and Quality Control”
Key learning:
Testing procedures (chemical and bacteriological) of raw materials and finished products used commercially.
Different stages of brewing and fermentation procedure.
Coordinating with relevant departmental staffs to achieve the testing of the same.
Supervised by: Dr. T. K. Dutta, Quality Assurance Manager, UBL, Kalyani unit.
Project Completed at: United Breweries Ltd., Kalyani unit
Duration of project: 24 days
SEMINARS/WORKSHOP ATTENDED 100th
Indian Science Congress Session, Kolkata, India, 3rd - 7th January, 2013. 8th International “MicroRNAs Europe 2013” Meeting on ‘MicroRNAs: Biology to
Development & Disease’ Peterhouse College, University of Cambridge, Cambridge, United Kingdom on November 4 - 5, 2013.
International Seminar on Emerging Trends In Cell & Molecular Biology, Jadavpur University, Kolkata, India, 14th December, 2012.
2nd
Global Cancer Genomics Consortium TMC Symposium, ACTREC, Mumbai, India, 19th – 21st November, 2012.
Participated in summer school of UGC-NRCBS at Madurai Kamaraj University on ‘Human Cellular Functional Assays’ (27 June –10 July 2011).
PUBLICATIONS IN PEER-REVIEWED JOURNAL
1. Sengupta D, Deb M, Rath SK, Kar S, Parbin S, Pradhan N, Patra SK. DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop. Exp Cell Res (2016). In press.
2. Sengupta D, Deb M, Rath SK, Kar S, Parbin S, Pradhan N and Patra SK. MiR- 193a regulates H3K4 trimethylation by regulating MLL1 and induces apoptosis in prostate cancer. (Manuscript submitted).
3. Sengupta D, Deb M, Rath SK, Kar S, Parbin S, Pradhan N and Patra SK. miR- 148a targets DNMT1 and induce apoptosis inhibit prostate cancer progression. (Manuscript submitted).
4. Kar S*, Sengupta D*, Deb M, Shilpi A, Parbin S, Rath SK, Pradhan N, Rakshit M, Patra SK. (2014) Expression profiling of DNA methylation-mediated epigenetic gene-silencing factors in breast cancer. Clin Epigenetics. 6(1):20. (* Equal contribution)
DIPTA SENGUPTA (Ph.D. scholar, Dept. Of Life Science, NIT Rourkela) 3
5. Sengupta D, Deb M, Kar S, Shilpi A, Parbin S, Mallick B and Patra SK. (2013). Epigenetic microRNA regulation of chromatin function and signaling pathways: A perspective in cancer. Epigenetic Diagnosis & Therapy. 1:81 – 90.
6. Rath SK, Deb M, Sengupta D, Kari V, Kar S, Pradhan N, Parbin S, Patra SK. (2016) Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin. Tumor Biology. In press.
7. Deb M, Sengupta D, Kar S, Shilpi A, Parbin S, Rath SK, Roy S, Das G and Patra SK (2016) Epigenetic drift towards histone modifications regulates CAV1 gene expression in colon cancer. Gene. 581(1):75-84.
8. Deb M, Sengupta D, Rath SK, Kar S, Parbin S, Shilpi A, Pradhan N, Roy S, Das G and Patra SK (2015) Clusterin gene is predominantly regulated by histone modifications in human colon cancer and ectopic expression of the nuclear isoform induces cell death. Biochim Biophys Acta. 1852(8):163045.
9. Parbin S, Shilpi A, Kar S, Pradhan N, Sengupta D, Deb M, Rath SK, Patra SK. (2015) Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer. Mol Biosyst. 12(1):4858.
10. Shilpi A, Parbin S, Sengupta D, Kar S, Deb M, Rath SK, Rakshit M and Patra SK (2015) Mechanisms of DNA methyltransferaseinhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. Chem Biol Interact. 233:12238.
11. Deb M, Sengupta D, Kar S, Rath SK, Parbin S, Shilpi A, Roy S, Das G and Patra SK (2014) Elucidation of Caveolin 1 both as a tumour suppressor and metastasis promoter in light of epigenetic modulators. Tumor Biology. 35(12):1203147. 12. Deb M, Kar S, Sengupta D, Shilpi A, Parbin S, Rath SK, Londhe V and Patra SK
(2014) Chromatin dynamics: H3K4 methylation and H3 variants replacement in development and cancer. Cellular and molecular life sciences, 71:3439-3463. 13. Parbin S, Kar S, Shilpi A, Sengupta D, Deb M, Rath, SK and Patra SK (2013)
Histone deacetylases: A saga of perturbed acetylation homeostasis in cancer. J Histochem & Cytochem, 62(1):11-33.
14. Kar S, Parbin S, Deb M, Shilpi A, Sengupta D, Rath SK, Rakshit M, Patra A and Patra SK (2013) Epigenetic Choreography of Stem Cells: the DNA demethylation episode of development. Cell Mol Life Sci., 71(6):1017-32.
15. Deb M, Sengupta D and Patra SK (2012) Integrin-Epigenetics: A system with imperative impact on cancer. Cancer Metast. Rev., 31:221–234.
16. Kar S, Deb M, Sengupta D, Shilpi A, Parbin S, Torrisani J, Pradhan S and Patra SK (2012) An insight into the various regulatory mechanisms modulating Human DNA Methyltransferase 1 stability and function. Epigenetics, 7(9):994-1007. 17. Kar S, Deb M, Sengupta D, Shilpi A, Bhutia SK and Patra SK (2012) Intricacies
of Hedgehog Signaling Pathways: A perspective in tumorigenesis. Exp Cell Res., 318: 1959-1972.
CONFERENCE PROCEEDINGS
Sengupta D, Deb M, Kar S, Rath S K, Shilpi A, Parbin S, Patra SK Modulation of miR-152 by epigenetic modulator in breast cancer.
In: 8th International “MicroRNAs Europe 2013” Meeting on ‘MicroRNAs:
Biology to Development & Disease’ Peterhouse College of the University of Cambridge, Cambridge, United Kingdom on November 4 - 5, 2013.
DIPTA SENGUPTA (Ph.D. scholar, Dept. Of Life Science, NIT Rourkela) 4
Sengupta D, Deb M, Kar S, Shilpi A, Parbin S, Patra SK. Expression profiling of DNA Methyltransferases 1 in breast cancer.
In: 100th Indian Science Congress Session, Kolkata, India, 3rd - 7th January, 2013. Sengupta D, Deb M, Kar S, Shilpi A, Parbin S, Patra SK. Expression of DNMT1
and its modulation by epigenetic modifiers in breast cancer cells.
In: International Seminar on Emerging Trends In Cell & Molecular Biology,
Jadavpur University, Kolkata, India, 14th December, 2012
Deb M, Sengupta D, Kar S, Shilpi A, Parbin S, Patra SK. Caveolin and Clusterin expression and functional co-relation with human breast cancer.
In: 100th Indian Science Congress Session, Kolkata, India, 3rd - 7th January, 2013. Deb M, Sengupta D, Kar S, Shilpi A, Parbin S, Patra SK. Clusterin expression and
its epigenetic control switch in human breast cancer.
In: 2nd Global Cancer Genomics Consortium TMC Symposium, ACTREC, Mumbai, India, 19th – 21st November, 2012.
Patra SK, Deb M, Sengupta D, Kar S, Shilpi A. Molecular mechanisms of DNA- methylation during development, ageing and cancer: DNA-methyltransferase and DNA demethylase in action.
In: National Seminar on Current Trends in Chemistry–VI (NSCTC-VI), Kalyani
University, West Bengal, India, 2nd March, 2012.
Patra SK, Deb M, Sengupta D, Kar S, Shilpi A. Reversible methylation at DNA- cytosine-5-carbon by DNA methyltransferase and possible mechanism of inhibition by 5- aza-2’-deoxycytidine.
In: Biochemical Society Annual Symposium, Cambridge, UK, 10th - 12th January, 2012.
Kar S, Deb M, Sengupta D, Shilpi A, Parbin S, Pradhan N, Rath SK, Patra SK. MBD proteins as prognostic biomarkers for epigenetic cancer therapy.
In: 100th Indian Science Congress Session, Kolkata, India, 3rd - 7th January, 2013. Kar S, Deb M, Sengupta D, Shilpi A, Patra SK.
DNA methylation as a prognostic marker: Diagnostic and therapeutic implications in cancer research.
In: 1st Global Cancer Genomics Consortium TMC Symposium, ACTREC, Mumbai, India, 10th - 12th November, 2011.
LIST OF AWARDS AND GRANTS
Ph.D. Scholarship from MHRD at NIT Rourkela, India. GATE-2010 and GATE-2012 Examination Qualified, India. ARS NET 2016 Qualified, India
Newton International Fellow 2016 PERSONAL INFORMATION
Name Dipta Sengupta
Father’s Name Abhik Sengupta Mother’s Name Anjana Sengupta Date of Birth 30th June, 1986 Marital Status Unmarried
Religion Hindu
Category General
DIPTA SENGUPTA (Ph.D. scholar, Dept. Of Life Science, NIT Rourkela) 5
REFERENCES
Dr. Samir Kumar Patra Associated Professor
Epigenetic and Cancer Research Laboratory
Department of Life Science National Institute of Technology, Rourkela Odisha, India Mobile: (+91) 9438168145 Phone (O):0661-2462683 Phone (R):0661-2463683 Email Id:[email protected]
Dr. Partho Sarothi Ray Assistant Professor
Department of Biological Sciences
Indian Institute of Science Education and Research, Kolkata West Bengal, India
E-mail: [email protected]
Dr. Surajit Das Assistant Professor
Laboratory of Environmental Microbiology and Ecology Department of Life Science National Institute of Technology Rourkela, Odisha
India
Mobile: (+91) 9438168145 Phone (O): 0661-2462684 Phone (R): 0661-2463684 Email Id: [email protected]
DECLARATION
I hereby declare that all the above information is true in best of my knowledge and belief.
Date: 28.11.2016