– PARTES RELACIONADAS

The field of epigenetics investigates processes in cells, which take place above the level of genetics, namely processes that alter gene function without changing the deoxyribonucleic acid (DNA) sequence (Fazzari & Greally, 2010; Sweatt, 2013). In the recent years epigenetics have received a lot of attention in research and a broad range of applications in several domains. Within this thesis the focus is restricted to epigenetics in neuroscience, also termed as neuroepigenetics by Sweatt (2013). In his review Sweatt (2013) divides the major epigenetic molecular mechanisms into eight different categories. DNA cytosine methylation, a subcategory of the covalent DNA modification category, is one of the most studied epigenetic mechanisms given its strong regulatory influence on gene transcription (Fazzari &

Greally, 2010; Sweatt, 2013) and is within the focus of this thesis. DNA methylation seems to occur preferentially at cytosine-guanine dinucleotide (CpG) DNA sequences, so called CpG sites, but according to recent findings can occur as well at non-CpG sites (Fazzari & Greally, 2010; Sweatt, 2013). Various statistical methods, already used in analysis of other large data sets, are applied as well in methylation analysis (for a review see Fazzari & Greally (2010)).

Methodological approaches for statistical analyses of methylation data are still emerging.

Different normalization, pre- and post-processing strategies for large-scale methylation data (in the case of whole-genome methylation data) are getting introduced. For a methodological approach proposal see Milnik et al. (in preparation).

ORIGINAL RESEARCH PAPERS

29 4. ORIGINAL RESEARCH PAPERS

4.1. GENDER-DEPENDENT DISSOCIATION BETWEEN EMOTIONAL APPRAISAL AND MEMORY: A LARGE–SCALE BEHAVIOURAL AND FMRI STUDY

Spalek, K., Fastenrath, M., Ackermann, S., Auschra, B., Coynel, D., Frey, J., Gschwind, L., Hartmann, F., van der Maarel, N., Papassotiropoulos, A., de Quervain, D. J.-F., & Milnik, A., in preparation (a).

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In document FONDO DE INVERSION FYNSA RENTA FIJA PRIVADA II Estados Financieros al 30 de septiembre de 2020 y al 31 diciembre2019 (página 36-39)