(Supported by an educational grant from the Council on Undergraduate Research (CUR) and Research Corporation for Science Advancement)
MON. 9:55 AM—SAN DIEGO CONVENTION CENTER, 1A
CHAIRED: J. PROVOST
9:55 Chair’s introduction.
10:00 223.1 Developing administrative/organizational skills.
J.S. Bond. Penn State Col. of Med.
10:25 Gaining those important lab skills: three
different training programs at a liberal arts college. A. Brower, R. Romano, D. Columbus and A. Aguanno. Marymount Manhattan Col. and Boston Univ. Sch. of Publ. Hlth. (619.5)
10:50 223.2 Opportunities in the private sector. M.
Rosenberg. Promega Corp. and Univ. of Wisconsin-Madison.
11:15 Myth busters: 10 things you don’t know that you
think you know about launching a career at a predominantly undergraduate institution. R.S. Rowlett and K.A. Parson. Colgate Univ., NY and Macalester Col., MN. (617.2)
11:40 223.3 Effective use of social networking for career
development. L.M. Balbes. Balbes Consultants LLC, Kirkwood, MO.
12:05 Conclusion.
224.
EFFECTIVELY COMMUNICATING YOUR
SCIENCE
Public Affairs Workshop
(Sponsored by: ASBMB Public Affairs Advisory Committee)
MON. 12:30 PM—SAN DIEGO CONVENTION CENTER, 6B
It has never been more important to communicate science and it’s importance to the public. How can we make scientifi c discovery a high national priority? What can each of us do locally to make a difference? Join Nobel laureate, P. Berg, NPR science correspondent, J. Palca, science communicator, M. J. Palmer,
Huffi ngton Post science correspondent, C. Santa Maria and moderator J. Berg, for a panel discussion of how to get through to challenging audiences and make the best case for a long term investment in and focus on science.
225.
LIPID DROPLETS: BASIC WORKING
PRINCIPLES
Workshop(Supported by an educational grant from Avanti Polar Lipids, Inc.)
MON. 12:30 PM—SAN DIEGO CONVENTION CENTER, 11A
Lipid droplets, organelles found in cells of vertebrates, invertebrates, and plants, have received much attention of late due to their importance in lipid-based diseases, host-pathogen interactions, and in the production of biofuels. This workshop will focus on the working principles and methodologies of lipid droplet research to engage those interested in expanding their knowledge or entering this fi eld of research.
Light refreshments will be hosted. General seating available and doors open 15 minutes prior to event start.
Organizer:
R. V. Stahelin, Indiana Univ. Sch. of Med.-South Bend. Presenters :
D. Brasaemle, Rutgers Univ. T. Walther, Yale Univ.
D. Silver, Albert Einstein Col. of Med.
226.
RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE
AWARD LECTURE
AwardMON. 2:55 PM—SAN DIEGO CONVENTION CENTER, 6B
2:55 Introductory remarks. T. Landefeld.
3:00 226.1 Changing the course of America through
mentoring. L.A. Jones. Univ. of Texas M.D. Anderson Cancer Ctr. and Univ. of Houston.
227.
FUNDAMENTAL MECHANISMS IN GENE
REGULATION
SymposiumMON. 3:45 PM—SAN DIEGO CONVENTION CENTER, 6F
CHAIRED: K. ADELMAN
3:45 Chair’s introduction.
3:50 227.1 Structure and mechanism of the human
transcription initiation machinery. D. Taatjes, C. Bernecky, Z. Poss and C. Ebmeier. Univ. of Colorado at Boulder.
4:15 Mastermind-like 1 is ubiquitinated: functional
consequences for Notch signaling. B. White, M. Farshbaf, M.J. Lindberg, S. Behmner and A.E. Wallberg. San Jose State Univ. and Karolinska Inst. (734.9)
61
M
O
N
4:30 227.2 The mediator of RNA polymerase II transcription:
links to transcription elongation and leukemogenesis. J.W. Conaway, H. Takahashi, T.J. Parmely, C. Tomomori-Sato, S. Sato and R.C. Conaway. Stowers Inst. for Med. Res. and Hokkaido Univ. Grad. Sch. of Med.
4:55 Architecture of the mediator head module.
Y. Takagi, T. Imasaki, G. Cai, K. Yamada, I. Berger and F. Asturias. Indiana Univ. Sch. of Med., The Scripps Res. Inst. and European Molec. Biol. Lab., Grenoble. (731.1)
5:10 Arrangement of the 4.5 Myb domain repeats of
SNAP190 on the U1 gene promoter. W.E. Stumph, M. Doherty and Y.S. Kang. San Diego State Univ. (731.9)
5:25 227.3 Long non-coding RNAs in epigenetic
regulation. R. Shiekhattar. Wistar Inst.
5:50 Conclusion.
228.
NETWORKS AND TIME
Symposium
MON. 3:45 PM—SAN DIEGO CONVENTION CENTER, 6E
CHAIRED: M. BULYK
3:45 Chair’s introduction.
3:50 228.1 Measuring and modeling life-death decisions in
single cells. P.K. Sorger, C. Lopez, D. Flusberg, H. Eydgahi, J. Bachman, J. Sims, W. Chen, S. Spencer and S. Gaudet. Harvard Med. Sch.
4:15 Modeling receptor-mediated uptake of polymer-
functionalized iron oxide nanoparticles by macrophages. O. Lunov, V. Zablotskii, T. Syrovets, C. Roecker, K. Tron, G.U. Nienhaus and T. Simmet. Ulm Univ., Germany, Inst. of Biophys., Acad. of Sci. of Czech Republic and Karlsruhe Inst. of Technol., Germany. (773.4)
4:30 228.2 Transcription and pre-mRNA processing in
space and time. K.M. Neugebauer. Max Planck Inst. for Cell Biol. and Genet., Dresden.
4:55 Regulatory dynamics of the transcriptional
network controlling the cold shock response in Saccharomyces
cerevisiae. K.D. Dahlquist, B.G. Fitzpatrick, N.A. Rohacz and
K. Sherbina. Loyola Marymount Univ., CA. (772.1)
5:10 Combinatorics of cis-regulatory element
evolution in stress response modules of ascomycete yeasts. A. García-González, S. Roy, J. Konieczka, D. Thompson and A. Regev. Univ. of Puerto Rico, Rio Piedras and Broad Inst. of MIT and Harvard. (731.11)
5:25 228.3 Combinatorial and temporal codes within
pathogen-responsive gene regulatory networks. A. Hoffmann. UCSD.
5:50 Conclusion.
229.
PROTEIN TARGETING AND TRANSLOCATION
Symposium
MON. 3:45 PM—SAN DIEGO CONVENTION CENTER, 6D
CHAIRED: J. PUGLISI
3:45 Chair’s introduction.
3:50 229.1 Mapping out forces that act on transmembrane
helices during membrane insertion. G. von Heijne. Stockholm Univ.
4:15 Interplay between signal sequence recognition
and N-terminal protein modifi cation at the ribosome exit site. M. Pool, Y. Nyathi, G. Forte and C. Stirling. Univ. of Manchester, U.K. and Curtin Univ., Australia. (542.2)
4:30 229.2 Higher order assemblies in the GET membrane
protein targeting pathway. W. Clemons, J. Chartron and C. Suloway. Caltech.
4:55 Regulation of the Get3 ATPase cycle. M.E.
Rome and M. Rao. Caltech. (753.5)
5:10 Nucleotide-dependent conformational changes
in the N-ethylmaleimide sensitive factor and their potential role in SNARE complex disassembly. A. Moeller, C. Zhao, M.G. Fried, E.M. Wilson-Kubalek, B. Carragher, C.S. Potter and S.W. Whiteheart. The Scripps Res. Inst., Univ. of Kentucky and UCSD Sch. of Pharm. (751.4)
5:25 229.3 The unfolded protein response in health and
disease. P. Walter. UCSF.
5:50 Conclusion.
230.
CHEMISTRY IN THE SERVICE OF MEDICINE
Symposium
MON. 3:45 PM—SAN DIEGO CONVENTION CENTER, 6C
CHAIRED: P. COLE
3:45 Chair’s introduction.
3:50 230.1 Inhibitors of heat shock proteins in cancer
treatment. G. Chiosis. Mem. Sloan-Kettering Cancer Ctr.
4:15 Dynamics of induced-fi t in HIV reverse
transcriptase specifi city and resistance. K.A. Johnson, S. Kirmizialtin, V. Nguyen, A. Li and R. Elber. Univ. of Texas at Austin. (964.5)
4:30 230.2 Using small molecules to engineer and explore
human immunity. D.A. Spiegel. Yale Univ.
4:55 Toward development of selective DXP synthase
inhibitors. C.L. Freel Meyers and F. Morris. Johns Hopkins Univ. Sch. of Med. (964.4)
5:10 Allosteric regulation of protein kinase PKCζ by
the N-terminal C1 domain and small compounds to the PIF- pocket. R.M. Biondi, J.O. Schulze, W. Fröhner, H. Zhang, N. Weber, J. Navratil, S. Amon, V. Hindie, S. Zeuzem, T.J.D. Jørgensen, P.M. Alzari, S. Neimanis, M. Engel and L.A. Lopez-Garcia. Univ. Clin. Frankfurt, Univ. of Saarland, Univ. of Southern Denmark and Pasteur Inst., Paris. (558.2)
5:25 230.3 Tackling targets in epigenetics. P.A. Cole.
Johns Hopkins Univ. Sch. of Med.
5:50 Conclusion.
231.
SIGNALING AND METABOLISM
Symposium
MON. 3:45 PM—SAN DIEGO CONVENTION CENTER, 6A
CHAIRED: E. WHITE
3:45 Chair’s introduction.
3:50 231.1 Hormonal and cellular control of hepatic lipid
metabolism. J. Rutter. Univ. of Utah.
4:15 Thioesterase superfamily member 2 (Them2)
promotes the hepatic oxidation of plasma-free fatty acids. H.W. Kang, S. Han and D.E. Cohen. Brigham and Women’s Hosp. (562.1)
62
4:30 231.2 NAD metabolism: mechanisms of lifespan
extension in yeast and nicotinamide riboside utilization in a healthy 50-year-old man. C. Brenner, S. Trammell, S-C. Mei and M. Migaud. Univ. of Iowa and Queen’s Univ. Belfast.
4:55 Hydrogen sulfi de regulates hypoxic signaling
in T cells. T.W. Miller, T. Song, S. Amarnath, D.H. Fowler and D.D. Roberts. NCI/NIH. (758.6)
5:10 The JAK kinase Tyk2 and the signal transducer
and activator of transcription 3 are required for brown adipose tissue differentiation. A.C. Larner, M. Derecka, A. Gornicka, K. Szczepanek, M. Morgan, V.B. Raje, J. Sisler and S. Keller. Virginia Commonwealth Univ. and Univ. of Virginia. (758.9)
5:25 231.3 AMPK control of metabolic signaling. R. Shaw.
Salk Inst. for Biol. Studies.
5:50 Conclusion.