Presentación de Resultados

Chapter 9

Curriculum Vitae and List of Publications

Wouter Bult was born on September 4, 1979, in the picturesque little town of Putte, situated at the Dutch-Belgium border. He finished his secondary school in 1997 at the RSG ‘t Rijks in Bergen op Zoom. In that same year, he commenced the study of pharmaceutical sciences at Utrecht University, the Netherlands. During the master phase, he performed a research project of 6 months at the Victorian College of Pharmacy in Melbourne, Australia. In May 2004, he obtained his pharmacists degree. Wouter subsequently worked as a pharmacist at the Utrecht Veterinary School. In December 2005, Wouter started his PhD project at the Department of Nuclear medicine of the University Medical Center Utrecht, in close cooperation with the Utrecht Institute of Pharmaceutical Sciences, which resulted in this thesis. As of June 1, 2010, he started working as a pharmacist at the Department of Hospital and Clinical Pharmacy of the University Medical Centre Groningen. Wouter is married to Rosemarie Wasmann, and they have a daughter named Sophie.

Wouter Bult is op 4 september 1979 geboren in het kleine pittoreske dorp Putte, gelegen op de grens van Nederland en België. In 1997 rondde hij op RSG ’t Rijks te Bergen op Zoom de middelbare school succesvol af, en begon in datzelfde jaar aan de studie Farmacie in Utrecht. Tijdens de doctoraalfase van deze studie heeft hij 6 maanden onderzoek gedaan aan de Victorian College of Pharmacy in Melbourne, Australië. In mei 2004 ontving hij de apothekersbul. Vervolgens trad hij in dienst als apotheker bij de Apotheek Diergeneeskunde, aan de Faculteit der Diergeneeskunde in Utrecht. In december 2005 is hij begonnen aan het promotieonderzoek op de afdeling Nucleaire Geneeskunde in samenwerking met het Utrecht Institute for Pharmaceutical Sciences, wat uiteindelijk geleid heeft tot dit proefschrift. Op 1 juni 2010 is hij gestart met een baan als projectapotheker in het Universitair Medisch Centrum Groningen. Wouter is getrouwd met Rosemarie Wasmann, en ze hebben samen een dochter, Sophie.

Chapter 9 Articles

Boeve M, Bult W. Diclofenamide. Tijdschr Diergeneeskd. 2005 Apr 15; 130(8): 256

Bult W, Seevinck PR, Krijger GC, Visser T, Kroon-Batenburg LM, Bakker CJ, Hennink

WE, van het Schip AD, Nijsen JF. Microspheres with ultrahigh holmium content for radioablation of malignancies. Pharm Res. 2009 Jun;26(6):1371-1378

Bult W, Vente MA, Zonnenberg BA, van het Schip AD, Nijsen JF. Microsphere

radioembolization of liver malignancies: current developments. Q J Nucl Med Mol Imaging. 2009 Jun; 53(3): 325-335

Vente MA, de Wit TC, van den Bosch MA, Bult W, Seevinck PR, Zonnenberg BA, de Jong HW, Krijger GC, Bakker CJ, van het Schip AD, Nijsen JF. Holmium-166 poly(L- lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model. Eur Radiol. 2010 Apr; 20(4): 862-869

Smits ML, Nijsen JF, van den Bosch MA, Lam MG, Vente MA, Huijbregts JE, van het Schip AD, Elschot M, Bult W, de Jong HW, Meulenhoff PC, Zonnenberg BA. Holmium-166 radioembolization for the treatment of patients with liver metastases: design of the first-in-man HEPAR trial. J Exp Clin Cancer Res. 2010 Jun 15;29:70

Bult W, Varkevisser R, Soulimani F, Seevinck PR, de Leeuw H, Bakker CJ, Luijten PR,

van het Schip AD, Hennink WE, Nijsen JF. Holmium Nanoparticles: preparation and in vitro characterization of a new device for Radioablation of Solid Malignancies. Pharm Res. 2010 Oct;27(10):2205-12.

Oerlemans C, Bult W, Bos M, Storm G, Nijsen JF, Hennink WE. Polymeric Micelles in Anticancer Therapy: Targeting, Imaging, and Triggered Release. Pharm Res. 2010 Aug 20. (Epub ahead of print)

Bult W, de Leeuw H, Steinebach OM, Wolterbeek W Th, Hennink WE, van het Schip

AD, Nijsen JF. Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy: an in vitro and in vivo stability study. Submitted

Bult W, Kroeze SG, Elschot M, Seevinck PR, Beekman FJ, Luijten PR, Hennink WE, de

Jong HW, van het Schip AD, Bosch JL, Nijsen JF, Jans JJ. Radioactive microspheres for treatment and multimodality imaging in a mouse model of kidney cancer. In

preparation

Bult W, Vente MA, Vandermeulen E, Seevinck PR, Saunders J, van het Schip AD,

Bakker CJ, Krijger GC, Peremans K, Nijsen FJ. Interstitial microbrachytherapy using holmium-166 acetylacetonate microspheres: a feasibility study in feline liver cancer patients. Submitted

Curriculum Vitae and List of Publications Abstracts (first and second authorship only)

Zielhuis SZ, Bult W, Vente MA, Nijsen JF, de Wit TC, Krijger GC, Seevinck PR, de Roos R, Zonnenberg BA, van Rijk PP, van het Schip AD. Preliminary studies on holmium-166 loaded liposomes for diagnostic and therapeutic purposes. European Association of Nuclear Medicine Annual Meeting 2006, Athens, Greece

Vente MA, Bult W, de Wit TC, Seevinck PR, Seppenwoolde JH, Zonnenberg BA, de Roos R, Krijger GC, van het Schip AD, Nijsen JF. Holmium-166 poly-L-lactic acid

microspheres for treatment of liver malignancies: treatment procedure

testing in a large animal model. International Researchgroup on Immuno-

Seevinck PR, Bult W, Nijsen JF, Vente MA, de Roos R, van het Schip AD, Bakker CJ. Highly loaded holmium microspheres for test dose detection and biodistribution prediction in internal radiation therapy of liver tumors. International Society of Magnetic Resonance in Medicine Annual Conference 2008, Toronto, Canada

Bult W, Krijger GC, Hennink WE, van het Schip AD, Nijsen JF. New microspheres with

high holmium–166 content for microbrachytherapy. World Biomaterials Conference 2008, Amsterdam, The Netherlands

Bult W, Vente MA, Vandermeulen E, Vermeire S, de Roos R, Hennink WE, van het

Schip AD, Peremans K, Nijsen JF. Intratumoral radioablation of liver tumors using holmium-166 microspheres: a pilot study. Biomaterials Asia 2009, Hong Kong, China

Bult W, Seevinck PR, Krijger GC, Bakker CJ, Hennink WE, van het Schip AD, Nijsen JF.

Multifunctional microspheres with ultrahigh holmium load for imaging and therapy. International Society of Magnetic Resonance in Medicine Annual Conference 2009, Honolulu, Hawaii

Bult W, Vente MA, Zonnenberg BA, Kirpensteijn J, Meij BP, van der Bovenkamp CG,

Peremans K, Vermeire S, Vandermeulen E, Dekkers E, Krijger GC, de Roos R, van het Schip AD, Nijsen JF. Interstitial microbrachytherapy in veterinary patients using small holmium-166 microspheres. European Association of Nuclear Medicine Annual Meeting 2009, Barcelona, Spain

Bult W, Kroeze SG, Beekman FJ, Bosch JL, Nijsen JF, Jans JJ. Holmium Loaded

Microspheres as novel minimally invasive therapy for kidney cancer. International Researchgroup on Immuno-Scintigraphy and Therapy Biannual conference 2010, Groningen, The Netherlands

Patent application

Nijsen JF, Bult W, van het Schip AD. A microsphere comprising an organic lanthanide metal complex. EP2178817.