Reducción de la dosis de DOX libre en líneas celulares establecidas

By now you should have a pretty solid grasp of what it takes to efficiently and effectively build muscle. You should know how to structure a killer workout, how to eat for maximal gains, which supplements are most effective and how to properly recover in between workouts. It may seem like a lot to remember, but in reality it is very straightforward and simple.

Once you start executing these principles on a consistent basis it will become nothing more than second nature. I'm confident that by now your mind has been cleansed of any nonsense or misleading information you had read in the past and that you now

understand why so many approaches simply do not work. Even so, I would still like to cover some common muscle-building myths and lies to further clear up any confusion you may have. Bodybuilding misinformation is rampant, abundant and spinning out of control.

Here are some common misconceptions that your average lifter would have no idea how to argue against. By the end of this section you will have hopefully cancelled your muscle magazine subscription, forgotten about "feeling the burn" and will have decided to forget about what Mr. Olympia Ronnie Coleman has to say about bicep training.

Myth #1: In order to build muscle, you must achieve a "pump" during your workout. The greater pump you achieve, the more muscle you will build.

For those of you who have never trained with weights before, a "pump" is the feeling you get as blood becomes trapped inside your muscles after a few sets in the gym. Your muscles will swell up, increase in size and vascularity and will also give you a great mental boost. There is absolutely nothing wrong with getting a pump, but contrary to popular belief it is definitely not indicative of an effective workout.

On countless occasions I've heard lifters raving about the massive pumps they get in the gym as they share methods for achieving the best pump possible.

"Dude, this will give you a crazy pump!"

If you have already been working out for a decent amount of time then you know exactly what I'm talking about.

While a pump does feel extremely satisfying, just remember that it means very little in terms of muscle stimulation and growth. Think of it this way: if I took a pair of 5 pound dumbbells and performed 200 reps of a bench press with them, my pump would be absolutely incredible. Blood would be rushing into my chest and it would feel rock-solid, thick and full. But do you think pressing 5-pound dumbbells for 200 reps would be an effective way of stimulating chest growth?

Absolutely not.

Do not concern yourself with your pump, and do not be discouraged if your pump is not as intense as you had hoped for. As I said before, it has nothing to do with how effective your workout has been, only progression does. If you were able to lift more weight or perform more reps with a certain weight in comparison to the previous workout, then you did your job. This is the only thing you should be concerning yourself with.

Myth #2: You should gauge the success of your muscle-building sets on the level of muscle burn you achieve.

Another huge misconception in the gym is the belief that in order to grow, you must

"feel the burn!" Well, to understand why "the burn" has nothing to do with completing a successful workout, you must first understand what this feeling is actually caused by.

When we exercise, our bodies produce natural waste products as a result of reactions going in within the muscles. One of these products, lactic acid, is produced within the muscle tissue as your body burns carbohydrates for use as fuel. So, what does this have to do with muscle growth?

Well, nothing!

In fact, lactic acid will actually have a negative effect on muscle stimulation by

influencing muscle catabolism. We usually experience the highest instance of muscle burn when we train with lighter weight and higher repetitions. This is yet another reason why we must avoid this type of training and instead focus on moving as much weight as possible for no more than 7 reps.

Muscle burn is inevitable, but it is definitely not something you should be striving for.

Myth #3: Bodybuilding professionals have more muscle than anyone on the planet. Therefore, they also have the most muscle-building knowledge.

One of the biggest mistakes you could possibly make is to take advice from bodybuilding magazines and from IFBB professionals. Just because these guys are the most massive and ripped dudes on the planet does not mean that they offer the best advice!

Professional bodybuilding is a shady and corrupt world, and is not a realm worth

venturing into. These guys are simply genetic freaks whose bodies will respond heavily to pretty much any type of training stimulus.

Not only are they extremely genetically gifted, but their potential is maximized even further because of the various steroids and hormones they use as a part of their programs.

Steroid use is a personal choice, and I am not here to advocate their use or to go on a rant about why you shouldn't use them, but the fact of the matter is that these pro bodybuilders have more steroids and synthetic hormones running through their bodies than most small hospitals have.

In a sport where more is always better, these guys are constantly pushing their bodies far beyond where they were intended to go. I'm not saying that what they are doing is wrong, all I am saying is that for mere mortals like us there is really no point in trying to employ their training tactics into our programs.

I don't care what "the big guy" at your gym says, or what Mr. Olympia Ronnie Coleman has to say. If certain unorthodox techniques work for these genetic freaks, fine, but for the other 99% of us humans, these techniques simply will not work and should not be followed.

Myth #4: Muscle Magazines are a good place to do muscle-building research

While I'm on the subject of professional bodybuilders, I'd like to quickly talk to you about bodybuilding magazines and why you shouldn't read them. Have you ever noticed that over half of a bodybuilding magazine's content is advertisements for various

supplements and "get-big-quick schemes?" Have you noticed that they actually disguise advertisements as articles? It's basically page after page of "the latest breakthrough"

that promises to get you huge in a matter of days.

Well, that's the reason why these magazines are produced in the first place! They are basically gigantic advertisements used to push all sorts of products on you that you don't really need.

Now don't get me wrong, supplementation definitely has its place, and we covered that subject earlier in the book, but there are a lot more bogus supplements out there than there are legit ones. The right supplements, such as protein powders, creatine,

glutamine and EFA's can help you reach your goals faster you than you would without them. However, if you go beyond these few, basic supplements you may end up wasting your money.

Forget about citrulline, myostatin blockers and ecdysterone. All of this stuff is nothing more than a giant marketing scam used to empty your pockets. The magazines will push anything and everything as long as it makes them money. Not only that, but the

majority of the training articles you read are about the techniques used by the pros. If you want to read a bodybuilding magazine for its entertainment value, by all means go ahead. Just don't take any of the advice to heart, as it probably will do you more harm than good.

Myth #5: High-protein diets should not be followed because they are stressful to the kidneys.

This issue has been debated for years and years. The truth is that the majority of the studies performed that suggested a high protein diet was bad for the kidneys have been shown to be false, and have been replaced by newer and more accurate research. Don't allow yourself to fall victim to the media.

The bottom line is that there has never been a single study ever performed that has been able to clearly demonstrate a negative relationship between high protein intake and kidney function.

So where did this myth come from?

Who knows, but based on modern research, there is no reason to suspect that these claims have any truth to them at all.

Myth #6: The body can only absorb a maximum of 30 grams of protein in one sitting.

How often have you heard this one? The "30 grams of protein per meal" limit seems to have become a basic rule in bodybuilding circles. The idea is that the body can only absorb a maximum of 30 grams of protein at one sitting, and anymore will simply go to waste.

The real question is where did this piece of conventional wisdom come from, and what scientific evidence is there to support it?

Well, the answer is who knows and none.

That is, we don't know where it came from, and there is no evidence to support it.

The digestion of protein is an extremely complicated process and involves much more than a piece of food simply being chewed and sent to the stomach and intestines for absorption. The digestion process involves all sorts of fancy enzymes (protease,

peptidase and trypsin to name a very small few), acids (HCL) and other substances (bile salts, gastrin, CCK) that are secreted from the mouth, stomach and small intestine.

There are numerous sites along the digestion tract that would affect how much or how little a person could absorb in terms of protein. Because of this, we don't really know what the upper limit for protein absorption really is. It would seem that the number would differ from person to person. It makes sense to say, for example, that a 250-pound bodybuilder could absorb more protein in one sitting than a 95-250-pound ballerina.

I'm not necessarily saying that the "30 gram rule" is wrong, all I'm saying is that there's no real reason to believe it's correct. If you were to consume 50 grams of protein in one meal, there’s no reason to suspect that the extra 20 grams has somehow gone to waste.

Myth #7: Performing high reps with light resistance will make the muscles more cut and defined.

This is one of the most common misconceptions when it comes to bodybuilding and fitness in general. Allow me to clear this up once and for all…

You cannot target fat loss from a specific area on your body!

Performing bicep curls will not burn fat from your biceps, just as performing crunches will not give you a flat, ripped midsection. Fat loss targeting is completely genetic, and your body will burn fat from wherever it sees fit.

Yet so often we see even serious lifters failing to recognize this and continuing to abide by the misguided notion that "high reps and light weight gets you ripped."

Whenever I'm in the gym during the few months leading up to summer, I always run into someone who tells me that they're focusing on using light weight and performing high reps to get "cut and defined" for the beach.

This is complete and total nonsense!

The bottom line is this: lifting weights builds muscle and performing cardio burns fat, plain and simple. This is not to say that building muscle has no effect on fat loss, because it definitely does. One of the most important factors that affects your resting metabolism is the amount of lean muscle mass you have on your body. All I'm saying is that manipulating the amount of weight you lift or the number of repetitions you perform will not magically cause your body to start burning higher amounts of fat from the area you're training.

Myth #8: You should switch up your routine periodically by changing your rep ranges and exercises in order to "shock" your muscles.

The idea of changing your rep range, exercises or training days in an attempt to "shock"

your muscles is a widely accepted “truth” in bodybuilding circles, but I have yet to come across any hard-fast evidence that proves this notion.

In order to maximize your muscle gains it's very important to let go of conventional wisdom and to question the so-called "accepted" methods of bodybuilding. You need to think of the concept of building muscle from outside the box.

Your muscles do not have a mind of their own. If you switch from using a dumbbell to a barbell to stimulate your tricep, the muscle does not magically think to itself "Oh no!

He's using a barbell now! We'd better pack on some extra muscle mass this time!"

Muscles adapt to stress, plain and simple.

Do you want to know the real secret for "shocking" your muscles?

Here it is: intensity and progression.

As long as you train with 100% intensity and focus on making steady progression in the weight you lift or the repetitions you perform, your muscles will continue to respond by growing larger and stronger. The bottom line is to present them with a workload they have never experienced before. That's all there is to it.

You’ll notice that in the 26-week workout plan I’ve provided a different schedule for every 8-week cycle. This is simply to keep things mentally fresh and interesting, and to allow you to have experience performing different exercises. It has nothing to do with

“shocking” your muscles.