1 HC013 - 07 Curled and bent bodies, some only show curled tails. Somites are slightly U-shaped and a retarded iaw. Slow heart beat, reduced
pigmentation in eyes and reduced blood circulation. 1 HC024 - 02 Oep like phenotype at 24 hours.
1 HJ032 - 02C Overproliferation of the posterior brain. MHB is disrupted. Looks like a snake head mutant. Cerebellum is also disrupted. 1 IF056 - 01 No hindbrain or forebrain ventricles, reduced otic vesicle size 1 IF084 - 02 Strong cyclops phenotype. Curly down tail and protruding jaw.
Eyes fused in the middle
1 IM021 - 02A Small eyes, flat small head, miss MHB.
1 IV045 - 04 No eyes, POC not closed, supraoptic tract shows defects.
1 JI055 - 03A Embryos lack ant. neural structures. Lack eyes and telencephalon. HB is disorganised, spinal cord is slightly disorganised.
2 HD014 - 12C Embryos were headless with a general curly tail phenotye
2 HE017 - 02A Dwarf - like, with kinky notochord, blocky somites and bumpy HB. 2 HE017 - 02C Dwarf - like, with kinky notochord, blocky somites and bumpy HB. 2 HE022 - 02A General brain cell death, no PC, curly down tail. HB and ant. brain fine. 2 HE409 - 01A No notochord, head strongly reduced by day 3.
2 HE409 - 01C No notochord, head strongly reduced by day 3.
2 HI090 - 01A Eyes small and close together. Resembles cyclops in severe cases. 2 H R 1 6 8 - 03 Elephant nose. Messy tubulin and HB disorganised.
2 HS298 - 03A Cell death in head, ventralised. Flat brain, small eyes, abnormal TPOC. 2 HS304 -03A Reduced staining in the otic vesicle
2 HU005 - 03A Smaller forebrain and short body, split tail. Retarded.
2 HU028 - 02 Déficiences tissue of the head. Some miss all head tissue. All lack eyes. 2 HX033 - 09A No notochord, only one eye in some cases. No Tub. staining ant. of the
trigeminal. No evidence of segmentation in the hindbrain.
2 HX033 - 09B No notochord, onlv one eye in some cases. No Tub. staining ant. of the trigeminal. No evidence of segmentation in the hindbrain.
2 HX033 - 09C No notochord, only one eye in some cases. No Tub. staining ant. of the trigeminal. No evidence of segmentation in the hindbrain.
2 HX051 - 03A Brain necrosis, elephant nose. Tub. shows a lack of AC and messy OB. 2 HX066 - ID Reduced brain vesicles, snakehead - like. No circulation mild oedema. 2 IB003 - 04 Coloboma, caudal fin expanded in some mutants.
2 IG430 - 03 Small head, flat hindbrain, MHB difficult to see.
2 IN171 - 08A Thin body axis, sSMNs do not proiect segmentally. Ectopic RBCs in HB. Flattened forebrain.
2 I N I 93 - 02A Large somites in DV axis, short spinal cord. Narrow HB and abnormal neural tissue close to cerebellum.
2 10005 - 08C Severe ant. trunction, no SMNs in the spinal cord; somites look abnormal. 2 10005 - 08D Severe ant. trunction, no SMNs in the spinal cord; somites look abnormal. 2 10005 - 0 8 E Severe ant. trunction, no SMNs in the spinal cord; somites look abnormal. 2 10005 - 08F Severe ant. trunction, no SMNs in the spinal cord; somites look abnormal. 2 IP113 - 02 Elevated telencephalon, notochord disrupted, no clear MHB.
3 HF017 - 01A Disrupted tectum, HB and cerebellum. No MHB. Tubulin shows no SOT. There may be increased Rohon-Beard cells in the spinal cord.
3 HF017 - 01B Disrupted tectum, HB and cerebellum. No MHB. Tubulin shows no SOT. There may be increased Rohon-Beard cells in the spinal cord.
3 HF017 - 0 1 0 Disrupted tectum, HB and cerebellum. No MHB. Tubulin shows no SOT. There may be increased Rohon-Beard cells in the spinal cord.
3 HF028 - 01A Bumpy rostral HB, expanded ventricles, small eyes. NT may be wider. 3 HF140 - 05A Short trunk, narrow somites, degenerated notochord, bumpy HB, no
3 HJ138 - 03A Enlarged HB vesicle. PC present but messy. Heads look larger than wt. 3 HK013 - 10A AC, MHB and POC are disrupted. Elephant nose. Tectum is disurpted.
Small eyes with ventral problems. Kink at the end of tail.
3 HK027 - 03A Ventralised, small body. Spinal neurons are absent or misspatterned. 3 HK027 - 03C Ventralised, small body. Spinal neurons are absent or misspatterned. 3 HK311 - 05 No TPC or epiphysis. Brain appears amorphous. Curly tail down. 3 HK314 - 05A Cell death in head. Some appear to have specific cell death in the HB. 3 HM158 - 05 S - shaped body. Tub. retarded and AC / POC are not closed. Reduced
epiphysis and telencephalon.
3 HN148 - 01 Flat head and no MHB folds present. Pax2 staining of MHB is fine. 3 HP023 - 04A No eyes, disrupted tubulin.
3 HS049 - 02 Elephant nose, no AC. HB commisures are disrupted, trigeminal is misshaped. Mild cell death seen.
3 HU519 - 03A Bumpy HB, bent tail. RBCs are scattered, comms. not formed properly. 3 HU519 - 03B Bumpy HB, bent tail. RBCs are scattered, comms. not formed properly. 3 HU519 - 03C Bumpy HB, bent tail. RBCs are scattered, comms. not formed properly. 3 HX137 - 01 LL veers ventrally for approx. 2 somites. Morphology defects in brain. 3 HX168 - 07A Lumpy HB, unclosed choroid fissure. Tub. shows no MHB, unclosed AC,
PC and POC, hindbrain is disorganised.
3 IA015 - 09A Dead head. AC not closed, PC not formed, HB disorganised. Short tail. 3 IS327 - 04A Tub. very disrupted, no scaffold ant. of the SC. No somites obvious. 3 IT419 - 13A No cerebellum. Anterior HB is disorganised, MHB also disorganised. 3 IT419 - 13B No cerebellum. Anterior HB is disorganised, MHB also disorganised. 3 IY001 - 05A Inflated HB, contriction at MHB. Small eyes, shorter body. Elephant
nose and mild cell deathin the head. Some show unclosed AC. 3 IY001 - 05C Inflated HB, contriction at MHB. Small eyes, shorter body. Elephant
nose and mild cell deathin the head. Some show unclosed AC.
3 Kl 104 - 03 Ant. brain morphology is very disrupted. Eyes are not always present. Tub. disrupted in HB.
3 KS015 - 02A Tub. very disrupted. Extra neurons are seen all over the brain. LL appears to originate in the middle of the SC instead of the lateral edge. 3 KS015 - 02B Tub. very disrupted. Extra neurons are seen all over the brain. LL
appears to originate in the middle of the SC instead of the lateral edge. 4 HC006 - 04A Retarded. Decreased distance between the AC and PC. HB is malformed. 4 HC006 - 07A Retarded. Decreased distance between the AC and PC. HB is malformed. 4 HE336 - 08 Reduced or no PC. Mild AC defect in the midline.
4 HE416 - 05 No PC, weak opsin staining. Some show weak PC and epiphysis staining. 4 HJ050 - 01 Tubulin staining shows that the AC is not closed.
4 HJ050 - 01A Tubulin staining shows that the AC is not closed. 4 HJ082 - 01A Weak tubulin staining in the supraoptic tract.
4 HK302 - 07 No MHB, rows of cells in the epiphysis are not separated. AC not closed. 4 HL030 - 03 AC and PC thickened with staining between the two. Other tub. fine. 4 HM030 - 04A Reduced or disorganised epiphysis.
4 HM030 - 04B Reduced or disorganised epiphysis.
4 HM079 - 02A Incomplete AC, often seen to be to close to the POC. Pathfinding defects. 4 HM079 - 02B Incomplete AC, often seen to be to close to the POC. Pathfinding defects. 4 HP325 - 03A AC not closed.
4 HZ378 - 16 AC not closed. Tubulin is messy, no epiphysis is present.
4 IA042 - 02A Tubulin shows lateral line defect - pathfinding errors in the lateral line. 4 IF075 - 04 Disorganised epiphysis, PC defasciculated. Disorganised SMNs. 4 IT704 - 01 CN5 is greatly reduced or absent. Seen in a more post, position. 4 JH055 - 03 AC delayed, TPOC is thicker than normal. HB is also disorganised - lack