Simulaciones numéricas

O.G.B., P.S., F.E., B.R., and E.S. designed research; O.G.B., J.S.R., P.S., J.B., and B.R.

performed research; J.S.R., M.S., H.-P.L., F.E., and B.R. analyzed data; O.G.B., H.-P.L., J.B., F.E., B.R., and E.S. wrote the paper; and E.S. provided funding.

4.5.8 References

1. Dallaspezia S & Benedetti F (2011) Chronobiological therapy for mood disorders.

Expert Rev Neurother 11:961-970.

2. Pflug B & Tolle R (1971) Disturbance of the 24-hour rhythm in endogenous depression and the treatment of endogenous depression by sleep deprivation. Int Pharmacopsychiatry 6:187-196.

3. Benedetti F, Barbini B, Colombo C, & Smeraldi E (2007) Chronotherapeutics in a psychiatric ward. Sleep Med Rev 11:509-522.

4. Wu JC & Bunney WE (1990) The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry 147:14-21.

5. Leibenluft E, Moul DE, Schwartz PJ, Madden PA, & Wehr TA (1993) A clinical trial of sleep deprivation in combination with antidepressant medication. Psychiatry Res 46:213-227.

6. Schilgen B & Tolle R (1980) Partial sleep deprivation as therapy for depression. Arch Gen Psychiatry 37:267-271.

7. Gillin JC, Buchsbaum M, Wu J, Clark C, & Bunney W, Jr. (2001) Sleep deprivation as a model experimental antidepressant treatment: findings from functional brain

imaging. Depress Anxiety 14:37-49.

8. Wu J, et al. (1999) Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. Am J Psychiatry 156:1149-1158.

9. Wu JC, et al. (1992) Effect of sleep deprivation on brain metabolism of depressed patients. Am J Psychiatry 149:538-543.

10. Wu JC, et al. (2008) Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depression. J Affect Disord 107:181-186.

11. Benedetti F, et al. (2007) Neural and genetic correlates of antidepressant response to sleep deprivation: a functional magnetic resonance imaging study of moral valence decision in bipolar depression. Arch Gen Psychiatry 64:179-187.

12. Clark CP, et al. (2006) Improved anatomic delineation of the antidepressant response to partial sleep deprivation in medial frontal cortex using perfusion-weighted

functional MRI. Psychiatry Res 146:213-222.

13. Clark CP, Frank LR, & Brown GG (2001) Sleep deprivation, EEG, and functional MRI in depression: preliminary results. Neuropsychopharmacology 25:S79-84.

14. Raichle ME & Snyder AZ (2007) A default mode of brain function: a brief history of an evolving idea. Neuroimage 37:1083-1090; discussion 1097-1089.

15. Wang L, Hermens DF, Hieckie IB, & Lagopoulos J (2012) A systematic review of resting-state functional-MRI studies in major depression. Journal of Affective Disorders 142:6-12.

16. Broyd SJ, et al. (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neurosci Biobehav Rev 33:279-296.

17. Buckner RL, Andrews-Hanna JR, & Schacter DL (2008) The brain's default network:

anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124:1-38.

18. Fox MD & Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8:700-711.

19. Raichle ME, et al. (2001) A default mode of brain function. Proc Natl Acad Sci U S A 98:676-682.

20. Niendam TA, et al. (2012) Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions. Cogn Affect Behav Neurosci 12:241-268.

21. Yu C, et al. (2011) Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation. Neuroimage 54:2571-2581.

22. Bush G, Luu P, & Posner MI (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 4:215-222.

23. Ongur D, Ferry AT, & Price JL (2003) Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol 460:425-449.

24. Sheline YI, Price JL, Yan Z, & Mintun MA (2010) Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus.

Proc Natl Acad Sci U S A 107:11020-11025.

25. Scheidegger M, et al. (2012) Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLoS One 7(9):e44799.

26. Bunney BG & Bunney WE (2012) Rapid-acting antidepressant strategies: mechanisms of action. Int J Neuropsychopharmacol 15:695-713.

27. De Havas JA, Parimal S, Soon CS, & Chee MW (2012) Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance. Neuroimage 59:1745-1751.

28. Samann PG, et al. (2010) Increased sleep pressure reduces resting state functional connectivity. Magma 23:375-389.

29. Gujar N, Yoo SS, Hu P, & Walker MP (2010) The unrested resting brain: sleep deprivation alters activity within the default-mode network. J Cogn Neurosci 22:1637-1648.

30. Price JL & Drevets WC (2010) Neurocircuitry of mood disorders.

Neuropsychopharmacology 35:192-216.

31. Drevets WC, Price JL, & Furey ML (2008) Brain structural and functional

abnormalities in mood disorders: implications for neurocircuitry models of depression.

Brain Struct Funct 213:93-118.

32. Drevets WC, Savitz J, & Trimble M (2008) The subgenual anterior cingulate cortex in mood disorders. CNS Spectr 13:663-681.

33. Kuhn S, Vanderhasselt MA, De Raedt R, & Gallinat J (2012) Why ruminators won't stop: The structural and resting state correlates of rumination and its relation to depression. J Affect Disord 141:352-360.

34. Sheline YI, et al. (2009) The default mode network and self-referential processes in depression. Proc Natl Acad Sci U S A 106:1942-1947.

35. Greicius MD, et al. (2007) Resting-state functional connectivity in major depression:

abnormally increased contributions from subgenual cingulate cortex and thalamus.

Biol Psychiatry 62:429-437.

36. Zhu X, et al. (2012) Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients. Biol Psychiatry 71:611-617.

37. Hamilton JP, et al. (2011) Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination. Biol Psychiatry 70:327-333.

38. Grimm S, et al. (2009) Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology 34:932-843.

39. Grimm S, et al. (2011) Reduced negative BOLD responses in the default-mode network and increased self-focus in depression. World J Biol Psychiatry 12:627-637.

40. McCabe C, et al. (2011) SSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex. Mol Psychiatry 16:592-594.

41. Cha YH, Chakrapani S, Craig A, & Baloh RW (2012) Metabolic and functional connectivity changes in mal de debarquement syndrome. PLoS One 7:e49560.

42. Di X & Biswal And Alzheimer's Disease Neuroimaging Initiative BB (2012) Metabolic Brain Covariant Networks as Revealed by FDG-PET with Reference to Resting-State fMRI Networks. Brain Connect 2:275-283.

43. Bullmore E & Sporns O (2012) The economy of brain network organization. Nat Rev Neurosci 13:336-349.

44. Baxter LR, Jr., et al. (1989) Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 46:243-250.

45. Bench CJ, et al. (1992) The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression. Psychol Med 22:607-615.

46. Cohen RM, et al. (1989) Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia.

Neuropsychopharmacology 2:241-254.

47. Mayberg HS (1994) Frontal lobe dysfunction in secondary depression. J Neuropsychiatry Clin Neurosci 6:428-442.

48. Mayberg HS (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9:471-481.

49. Mayberg HS, Lewis PJ, Regenold W, & Wagner HN, Jr. (1994) Paralimbic hypoperfusion in unipolar depression. J Nucl Med 35:929-934.

50. Buchsbaum MS, et al. (1997) Effect of sertraline on regional metabolic rate in patients with affective disorder. Biol Psychiatry 41:15-22.

51. Kennedy SH, et al. (2001) Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression.

Am J Psychiatry 158:899-905.

52. Drummond SP, et al. (2000) Altered brain response to verbal learning following sleep deprivation. Nature 403:655-657.

53. Levesque J, et al. (2003) Neural circuitry underlying voluntary suppression of sadness.

Biol Psychiatry 53:502-510.

54. Liotti M, et al. (2000) Differential limbic--cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders. Biol Psychiatry 48:30-42.

55. Parry BL, et al. (2000) Can critically timed sleep deprivation be useful in pregnancy and postpartum depressions? J Affect Disord 60:201-212.

56. Iber C, Ancoli-Israel S, Chessonn A, & Quan S (2007) The AASM Manual for the scoring of sleep and associated events: rules, terminology and technical specifications (Westchester, Illinois) 1st Ed.

57. Joel SE, Caffo BS, van Zijl PC, & Pekar JJ (2011) On the relationship between seed-based and ICA-seed-based measures of functional connectivity. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 66:644-657.

58. Fox MD, et al. (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A 102:9673-9678.

59. Forman SD, et al. (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 33:636-647.

5 Discussion

The purpose of this section is the combined discussion of the findings of the five studies with respect to the initial hypotheses and their embedding in the existing literature. First, the study results will be interpreted with respect to sleep-dependent memory consolidation and its application to emotional memory processing and extinction memory consolidation. In the end, future directions in sleep research and suggestion for future studies will be presented.

5.1 Specifying the neural mechanisms of sleep-dependent memory