Abbiw, D. (1990). Useful Plants of Ghana: West African Uses of Wild and Cultivated Plants, Intermediate Technology Publications, Royal Botanical Garden, Kew, London. Pp.105.
Alters, S., and Shiff, P.W. (1997). Impact of body mass index on coronary heart disease risk factors in men and women. Arterioscler. Thromb. Vasc. Biol. 16: 1509-15.
Alvarez, C., and Ramos, A. (1986). Lipids, lipoproteins and apolipoproteins in serum during infection. Clin. Chem. 32:142–5.
Amole, O.O., and Ilori, O.O. (2010). Antimicrobial Activity Of The Aqueous And Ethanolic Extracts Of The Stem Bark Of Alstonia Boonei. International Journal of Phytopharmacology. 1(2), 119-123.
Asuzu, I.U., and Anaga, A.O. (1991). Pharmacological screening of the aqueous extract of Alstonia boonei stem bark. Fitoter. 63:411–417.
Ballantyne, C. M., Hoogeveen, R. C., and Bang, H. (2005). Lipoprotein- associated phospholipase A2, highsensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the
Atherosclerosis Risk in Communities (ARIC) study. Arch. Intern. Med. 165:2479- 2484.
Bello, I.S., Oduola,T., Adeosun, O.G., Omisore, N.O.A., Raheem, G.O., and Ademosun, A.A (2009). Evaluation of anti-malarial activity of various fractions of Morinda lucida and Alstonia boonei stem bark. Global J. Pharmacol. 3(3): 163-165.
Bergmeyer, H.U., Bergmeyer, J., and Grassi, M. (1987). Methods in Enzymatic Analysis, 3rd ed Vol. VI Verlag. Chemie, Weinheim Germany.
Conner, E.M., and Grisham, M.B.(1996). a Inflammation, free radicals, and antioxidants. Nutrition. 12: 274-277.
Dashty, M., Motazacker, M., Levels, J., Vries, M., Mahmoudi, M., Peppelenbosch, M., and Rezaee, F. (2014). Proteome of human plasma very low density lipoprotein and low density lipoprotein exhibits a link with coagulation and lipid metabolism. J. Thromb. Haemost. 23 (111): 518-530.
Di Rosa, M., Giroud, J.P., and Willoughby, D.A. (1971). J. Pathol. 104, 15.
Dobiasova, M., and Frohlich, J. (2001). The plasma parameter log (TG/HDL-c) as an atherogenic index, correlation with lipoprotein particle size and esterification rate in apo B- lipoprotein-depleted plasma (FER sub. HDL). J. Clin. Biochem. 34: 583-585.
Elisabetsky, E., and Costa-Campos, L. (2006). The alkaloid alstonine: a review of its pharmacological properties. Evidence-Based Complementary and Alternative Medicine 3: 39-48.
Emokpae, A., Arogundade, A., and Adumaya, E. (2013). Use of atherogenic index of plasma in evaluating the potential cardioprotective effects of red wine consumption: Studies in Nigerian young adult volunteers. J. Nigerian Soci. Experimental Bio. 25 (3) 118-123.
Ferreira, S.H., Flower, R.J., Parsons, M.F., and Vane, J.R. (1974). Prostaglandins 8, 433.
Freidewald, T., Levy, L., and Fredrickson, D. (1972). Estimation of concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. J. Clin. Chem. 10: 499-50.
Galton, D. J., and Krone, W. (1999). Hyperlipidaemia in practice. 1st Ed., Gower
Med. Pub. N. Y. Pp 5-25.
Gbadamosi, I.T., Moody, J.O., and Lawal, A.M. (2011). Phytochemical screening and proximate analysis of eight ethnobotanicals used as antimalaria remedies in Ibadan. Nig. J. Appl. Biosci. 44: 2967-2971.
Gilroy, D.W., Lawrence, T., Perretti, M., and Rossi, A.G. (2004). Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov, 3:401-16.
Gonzalez-Gay, M.A., Gonzalez-Juanatey, C., and Martin, J. (2005). Rheumatoid arthritis: a disease associated with accelerated atherogenesis. Semin. Arthritis Rheum. ;35:8–17.
Gosse, B.K., Bryson, T.A., and Gokou, T. (1999). “Study of triterpenoids from Alstonia boonei.” Société Ouest-Africaine de Chimie. 5(8):123–128.
Gupta, M., Mazumder, U.K., Kumar, R.S., and Kumar, T.S. (2003). Studies on anti-inflammatory, analgesic and antipyretic properties of methanol extract of Caesalpinia bonducella leaves in experimental animal models. Iran J. Pharmacol. Ther. 2:30–34.
Harborne, J.B. (1973). Phytochemical methods. In: A Guide to Modern Techniques of Plant Analysis (Harborne JB, ed.). Chapman and Hall, London, p. 279.
Hausenloy, D., and Yellon, D. (2008). Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels. J. Heart. 94 (6): 706-714. Hawkey, C.J., Jackson L, Harper, S.E., Simon, T.J., Mortensen, E., and Lines,
C.R. (2001). Review article: the gastrointestinal safety profile of rofecoxib, a highly selective inhibitor of cyclooxygenase-2 in humans. Aliment Pharmacol Ther, 15:1-9.
Hirano, T., Nohtomi, K., Koba, S., Muroi, A.,and Ito, Y. (2008). A simple and precise method for measuring HDL-cholesterol subfractions by a single
precipitant followed by homogeneous HDL-cholesterol assay. J. Lipid Res. 49 (5): 1130-1136.
Hobbs, C.E. (1993). Alstonia boonei plant, In: Handbook of African Medicinal Plants, 3rd ed. C.R.C Prss, Boca, Rota F.L. pg 116-118.
Hurley, J.V. (1972). Acute inflammation. Edinburgh, London: Churchill Livingstone.
Idowu, O.A., Soniran, O.T., Ajana, O., and Aworinde, D.O. (2010). Ethnobotanical survey of antimalarial plants used in Ogun State, Southwest , Nigeria. Afr. J. Phar. Pharmacol. 4: 055-060.
Igbinosa, O.O., Igbinosa, E.O., and Aiyegoro, O.A. (2009). Antimicrobial activity and phytochemical gel: A review update. J Ethnopharmacol 68: 3-37.
Iwu, M.M. (1993). Handbook of African Medicinal Plants.CRC Press, Boca Raton, FL. pp 116–118.
Iyiola, O.A., Tijani, A.Y., and Lateef, K.M. (2011). Antimalarial Activity of Ethanolic Stem Bark Extract of Alstonia boonei in mice. Asian J. of Bio. Sciences 4(3): 235-243.
Kam, T.S., Nyeoh, K.T., Sim, K.M. and Yoganathan, K. (1997).“Alkaloids from Alstonia scholaris,” J. Phytochem. 45(6):1303–1305.
Koduru, S., Grierson, D.S.,and Afolayan, A.J. (2006). Antimicrobial activity of Solanum aculeastrum (Solanaceae). Pharamacol. Biology 44: 284-286.
Kritchersky, S. (1970). The role of Cholesterol as Vehicle Experimental Atherosclerosis. Am. J. Clin, Nutr. 23: 1105-1110.
Kucera, M., Marquis, V.O., and Kucerovah, N. (1972). Contribution to the knowledge of Nigerian medicinal plants. JLC separation and qualitative evaluation of Alstonia boonei alkaloids. Plantamedical 21: 343-346.
Kumar, S., Boehm, J., and Lee, J.C. (2003). p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov, 2:717-26.
Leung, D.Y., and Bloom, J.W. (2003). Update on glucocorticoid action and resistance. J Allergy Clin Immunol, 111:3-22.
Majekodunmia, S.O., Adegokeb, O.A., and Odekua, O.A. (2008). Formulation of the extract of the stem bark of Alstonia boonei as tablet dosage form. Tropical Journal of Pharmaceutical Research. 7 (2), 987-994.
Mora, S., Rifai, N., Burring, J.E., and Ridker, P.M. (2008). Fasting compared with Myasoedova, E., Crowson, C.S., and Kremers, H.M. (2011). Lipid paradox in
rheumatoid arthritis: the impact of serum lipid measures and systemic inflammation on the risk of cardiovascular disease. Ann. Rheum. Dis. 70:482–7.
Nawaz, H., Comerford, B.P., Njike, V.Y., Dhond, A.J., Plavec, M., and Katz, D.L. (2006). Repeated serum lipid measurements during the perihospitalization period. Am. J. Cardiol. 98:1379–82.
Nordlie, R.C., and Arion, W.J. (1966). Methods in Enzymology, 9: 619-625. Nwanjo, H. U. (2004). Lipids and Lipoproteins in Biochemistry for students of
pathology. 1st Ed., Laudry. Nigeria.
Ochei, J., and Kolhaktar, O. (2008). Medical laboratory science: Theory and practical. (7th ed.). McGraw Hill, New Delhi. Pp. 188-195.
Odebiyi, A., and Sofowora, A.E. (1978). Phytochemical screening of Nigerian medicinal plants. Part III. Lloydia 41:234–246.
Odugbemi, T.O., and Akinsulire, O.R. (2007). Medicinal plants useful for malaria therapy in Okeigbo, Ondo State, Southwest, Nigeria. Afr. J. Trad. CAM. 4(2): 191-198.
Oigiangbe, O.N., Igbinosa, I.B., and Tamo, M. (2010). Insecticial properties of an alkaloid from Alstonia boonei De Wild. J. Biopesticides. 3(1): 265-270. Ojewole, J.A.O. (1984). Studies on the pharmacology of echitamine, an alkaloid-
from the stem bark of Alstonia boonei L. (Apocynaceae). Int. J. Crude Drug Res. 22: 121–143.s
Olajide, O.A., Awe, S.O., Makinde, J.M., Ekhelar, A.I., Olusola, A., Morebise, O., and Okpako, D.T. (2000). Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J Ethnopharmacol 71 (1- 2): 179-186.
Oliver, B. (1960). Medicinal plants in Nigeria 1st edition. Nigerian College of Arts, Science and Technology Ibadan 43-53.
Osadebe, P.O. (2002). Anti-inflammatory properties of the root bark of a. boonei. Nig J Nat Prod Med. 6: 39-41.
Oze, G.O., Nwanjo, H.U., and Onyeze, G.O. (2007). Nephrotoxicty caused by the extract of Alstonia boonei (De Wild) stem bark in Guinea pigs. The Internet J. Nutr. and Wellness, 3(2): 1-9.
Palla, F. (2005). Alstonia boonei De Wild (Plant Resources of Tropical Africa).Repert.Spec. Nov. Regni. Veg.13: 382-397.
Raji, Y.I., Salmon, T.M., and Akinsomsoye, O.S. (2005). Reproductive functions in male rats treated with methanol extract of Alstonia boonei stem bark. African journal of biomedical research. 8(2): 105-111.
Rang, H.P. (2006). Drug discovery and development. Elsevier, Amsterdam. (Short textbook describing the principles and practice of drug discovery and development at the beginning of the 21st century).
Sahu, S., Chawla, R., and Uppal, B. (2005). Comparison of two methods of estimation of low density lipoprotein cholesterol, the direct versus Friedewald estimation. Indian J. Clin. Biochem. 20: 54–61.
Sidiyasa, K. (1998). Taxonomy, phylogeny, and wood anatomy of Alstonia (Apocynaceae). International Association of Plant Taxonomy 24(2): 16-23. Singh, M.P., and Panda, H. (2005). Medicinal Herbs with Their Formulations.
Daya Publishing house, Delhi, pp 88-90.
Sofowora, A. (1982). Medicinal plants and traditional medicine in Africa. 1st ed.,
p. 168. John Wiley and Sons Ltd., Chichester.
Spector, W.G., and Willoughby, D.A. (1963). The Inflammatory Response. Bacteriological Reviews, 27:117-149.
Taiwo, O.B., Kroes, B.H., Beukelman, C.J., Horsten, S.T.A.J., and Makinde, J.M. (1998). Activity of stem bark of Alstonia boonei de wild on human complement and polymorph nuclear leucocytes. JE 17: 13-15.
Telang, R.S., and chatterjee, S. (1990). Study on analgesic and anti-inflammatory avtivities of Vitex negunda Linn. Gen. pharmacol. 31(5): 363-366.
Tietz, N. (1990). Clinical guide to laboratory tests. (2nd ed.). W.B. Sauders
company. Philadephia. USA. Pp. 554-556.
Trease, G.E., and Evans, W.C. (1989). A Textbook of Pharmacognosy, 13th ed. Bailliere-Tindall Ltd., London, pp. 5–53.
Treasure, C. B., Klein, J. L., and Weintraub, W. S. (1995). Beneficial effects of cholesterol lowering Therapy on the coronary endothelium in patients with coronary heart diseases. N. Engl. J. Med. 332: 481-487.
Vane, J.R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin like drugs. Nature New Biology, 231:232-235.
Vinegar, R., Truax, J.F., Selph, J.H., Johnston, P.R., Venable, A.L., and McKenzie, K.K. (1987). Fed. Proc. 46, 118).
Whelan, C.J. (2003). Will non-steroid approaches to the treatment of inflammation replace our need for glucocorticoids? Current Opinion in Investigational Drugs, 4:536-543.
WHO (2002) Traditional Medicine Strategy 2002-2005, Geneva, World Health Organization.
Wright, C.W., Allen, D., Phillipson, J.D., Geoffrey, C.K., Warhurst, D.C., Massiot, G., and Le Men Oliver L. (1993). Alstonia species. Are they effective in malaria treatment? J. Ethnopharmacol. 40: 41-45.
APPENDIX
CALCULATION OF MEAN ± S.E.M VALUES OF PAW THICKNESS IN