CAPITULO 3 TALENTO
3.6 El talento se clasifica según la dimensión de dominio
1246
Symbiotic relationships can be classified in many ways, from mutualistic to parasitic. In 1247
many cases, the symbiont biosynthesizes natural products that can be utilized by the host. For B.
1248
neritina, the symbiont E. sertula synthesizes bryostatins using an unusual trans-AT PKS system. 1249
The mechanism by which the trans-AT recognizes the correct enzymatic domain for formation 1250
of the bryostatin polyketide is not fully characterized. The research of protein-protein 1251
interactions between trans-AT and the KS-AT interdomain regions has determined the potential 1252
PKS KS-AT region of the module location as where trans-AT interaction occurs. 1253
The bioactive bryostatins may also play a role in in the host-symbiont interaction. 1254
Understanding how the host adapts to symbiont-produced natural products will illustrate another 1255
mechanism of host-symbiont co-evolution. Bryostatins are useful in deterring the predation of B.
1256
neritina larvae, but are potent PKC activators via C1b domain binding. In this study, I 1257
determined binding affinities of bryostatin-1 and PMA compounds to PKC C1b domains from B.
1258
neritina and other Bugula spp. to establish the relative interaction with each Bugula spp. to 1259
bryostatins. These data can advance knowledge of how the Bugula host has potentially adapted 1260
to the symbiont-produced bryostatins over time. 1261
1262 1263
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