En viu i en directe: festivals, matinals i certàmens.

The studies performed in this dissertation have described diverse roles for the

inflammasome and the MDA5/type 1 interferon axis on both the pathogenesis of MHV infection and the regulation of the innate and adaptive immune system. Our work suggests that the role of the inflammasome related cytokine IL-1 is specific to the infectious model, and that IL-18 signaling drives protection through interferon gamma production. MDA5 signaling was shown to influence viral tropism and to provide an anti-

inflammatory influence to control a pathological immune response. Together, these data describe a complex, fundamental role in immune modulation for the earliest responders to infection. Changes in even the first steps of an immune response can alter disease course, subsequent stages of the immune response, and the ultimate resolution of infection, reinforcing why study of these early inflammatory pathways is so essential.

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