Anexo IV

(1)

Anexo IV

Colección de cromatogramas

(2)

(3)

Capítulo 2. α-Iminoamidas como precursores de iluros de azometino en la cicloadición 1,3-dipolar catalítica asimétrica

exo-11a

(+)-exo-11a; ≥ 99% ee

(4)

exo-11b

(+)-exo-11b; 99% ee

(5)

exo-11c

(+)-exo-11c; > 99% ee

(6)

Racemic exo-11d

Table 2, entry 1.

(+)-exo-4d; 99% ee

(7)

exo-11e

(+)-exo-11e; > 99% ee

(8)

exo-11f

(+)-exo-11f; 96% ee

(9)

exo-11g

(+)-exo-11g; 96% ee

(10)

Racemic exo:endo-11h

(+)-exo-11h; 98% ee

(11)

exo-11i

(+)-exo-11i; > 99% ee

(12)

Racemic exo-11j

(+)-exo-11j; > 99% ee

(13)

exo-11k

(+)-exo-11k; > 99% ee

(14)

exo-11l

(+)-exo-11l; > 99% ee

(15)

exo-11m

(+)-exo-11m; > 99% ee

(16)

exo-11n

(+)-exo-11n; 98% ee

(17)

exo-11o

(+)-exo-11o; 0% ee

(18)

exo-11q

(-)-exo-11q; 52% ee

(19)

exo-14a

(-)-exo-14a; > 99% ee

(20)

exo-14q

(-)-exo-14q; 94% ee

(21)

exo-15a

(-)-exo-15a; 98% ee

(22)

exo-15b

(-)-exo-15b; 96% ee

(23)

exo-20a

(+)-exo-20a; 94% ee

(24)

exo-21a

(-)-exo-21a; 70% ee

(25)

exo-22a

(-)-exo-22a; 71% ee

(26)

exo-23a

exo-23a; 0% ee

(27)

exo-28a

(+)-exo-28a; 94% ee

(28)

exo-29a

(+)-exo-29a; > 99% ee

(29)

exo-30a

(+)-exo-30a; 98% ee

(30)

exo-31a

(-)-exo-31a; > 99% ee

(31)

exo-32a

(+)-exo-32a; 90% ee

Tras recristalización, ≥ 99% ee

(32)

exo-41a

(+)-exo-41a; 91% ee

(33)

exo-42a

(+)-exo-42a; 89% ee

(34)

exo:endo-43a

(+)-exo-43a; 90% ee

(35)

Capítulo 3: Cicloadición 1,3-dipolar catalítica asimétrica entre iluros de azometino y alquiliden-azalactonas

trans:cis-64a

(+)-trans-64a; ≥ 99% ee

(36)

trans-64b

(+)-trans-64b; ≥ 99% ee

(37)

trans-64c

(+)-trans-64c; 98% ee

(38)

trans-64d

(+)-trans-64d; 95% ee

(39)

trans-64e

(+)-trans-64e; 98% ee

(40)

trans-64f

(+)-trans-64f; 98% ee trans y 88% ee cis

(41)

trans-64h

(+)-trans-64h; 99% ee

(42)

trans-64i

(+)-trans-64i; ≥ 99% ee

(43)

trans-64j

(+)-trans-64j; 98% ee

(44)

trans-64l

(+)-trans-64l; ≥ 99% ee

(45)

trans-64m

(+)-trans-64m; ≥ 99% ee

(46)

trans-64n

(+)-trans-64n; ≥ 99% ee

(47)

trans-66b

(+)-trans-66b; 99% ee

(48)

trans-66c

(+)-trans-66c; ≥ 99% ee

(49)

trans-66d

(+)-trans-66d; ≥ 99% ee

(50)

trans-66e

(+)-trans-66e; ≥99% ee

(51)

trans-66g

(+)-trans-66g; 97% ee

(52)

trans-66h

(+)-trans-66h; 93% ee

(53)

trans-66l

(+)-trans-66l; ≥ 99% ee

(54)

trans-66m

(+)-trans-66m; ≥ 99% ee

(55)

trans-66n

(+)-trans-66n; ≥ 99% ee

(56)

trans-66o

(+)-trans-66o; ≥ 99% ee

(57)

trans-66q

(-)-trans-66q; 74% ee

(58)

trans-66r

(-)-trans-66r; >99% ee

(59)

trans-66s

(+)-trans-66s; ≥ 99% ee

(60)

trans-66t

(+)-trans-66t; ≥ 99% ee

(61)

trans-66u

(+)-trans-66u; ≥ 99% ee

(62)

trans-67bb

(+)-trans-67bb; 99% ee

(63)

trans´-64f´

(+)-trans´-64f´; 99% ee

(64)

trans´-64e´

(+)-trans´-64e´; 55% ee

(65)

trans´-66fm´

(+)-trans´-66fm´; 29% ee

(66)

trans´-66fs´

(+)-trans´-66fs´; 44% ee

(67)

trans´-64a´

(+)-trans´-64a´; 0% ee

(68)

trans´-64b´

(-)-trans´-64b´; 0% ee

(69)

Capítulo 4: 1,3-dienos activados en reacciones de cicloadición [3+2] catalítica asimétrica

exo-72a

(+)-exo-72a; 98% ee

(70)

exo-72c

(+)-exo-72c; >99% ee

(71)

exo-72d

(+)-exo-72d; 96% ee

(72)

exo-72f

(+)-exo-72f; 99% ee

(73)

exo-72h

(+)-exo-72h; 99% ee

(74)

exo-72i

(+)-exo-72i; 93% ee

(75)

exo-72k

(-)-exo-72k; 98% ee

(76)

exo-72l

(+)-exo-72l; 92% ee

(77)

exo-72m

(+)-exo-72m; >99% ee

(78)

exo-72n

(+)-exo-72a; 94% ee

(79)

exo-72r

exo-72r; 32% ee

(80)

exo-72u

(+)-exo-72u; >99% ee

(81)

exo-72v

(+)-exo-72v; >99% ee

(82)

exo-72w

(+)-exo-72w; >99% ee

(83)

exo-72x

(-)-exo-72x; 96% ee

(84)

exo-72y

(-)-exo-72a; >99% ee

(85)

exo-72z

(+)-exo-72z; >99% ee

(86)

exo-72ab

(+)-exo-72a; 93% ee

(87)

exo-74a

(+)-exo-74a; >99% ee

(88)

exo-75c

(+)-exo-75c; 99% ee

(89)

exo-75d

(+)-exo-75d; >99% ee

(90)

exo-75e

(+)-exo-75e; 93% ee

(91)

exo-75f

(+)-exo-75f; >99% ee

(92)

exo-75g

(+)-exo-75g; 98% ee

(93)

exo-75h

(+)-exo-75h; >99% ee

(94)

exo-75i

(+)-exo-75i; 0% ee

(95)

exo-75l

(+)-exo-75j; >99% ee

(96)

exo-75l

(+)-exo-72a; 98% ee

(97)

endo-72a

(-)-exo-72a; 96% ee

(98)

endo-72f

(-)-endo-72f; 93% ee

(99)

endo-72i

(-)-endo-72i; 94% ee; exo-72i; 66% ee

(100)

endo-72n

(+)-exo-72n; 99% ee

(101)

endo-72u

(+)-endo-72u; 99% ee

(102)

exo:endo-72a

(-)-endo-72x; >99% ee y (-)-exo-72x; 63% ee

(103)

endo-72z

(-)-exo-72z; 90% ee

(104)

endo-72ab

(-)-endo-72ab; >99% ee

(105)

endo-75c

(-)-exo-75c; 78% ee

(106)

endo:exo-75e

(+)-endo-75e; 99% ee, exo-75e; 99% ee

(107)

exo:endo-75g

(+)-exo-75g; 73% ee (+)-endo-75g; 62% ee

(108)

endo-75j

(+)-exo-75j; >99% ee

(109)

endo-75l

(-)-exo-75l; 90% ee

(110)

α,β-endo-72a

(+)-α,β-endo-72a; 46% ee

(111)

77a

(+)-77a, 91% ee

(112)

77e

(+)-77e, 46% ee

(113)

77g

(+)-77g, >80% ee