Syndromal and subsyndromal disease status and five-year morbidity using International Society for Bipolar Disorders criteria compared with alternative criteria. Opinions and beliefs of the Spanish population about serious mental illnesses (schizophrenia and bipolar disorder). Incidence of a positive screen for anxiety and/or depressive symptoms in HIV-1-infected patients in the UK - The CRANIum Study.
Herpes simplex virus type I induces the accumulation of intracellular beta-amyloid in autophagic compartments and inhibition of the non-amyloidogenic pathway in human neuroblastoma cells. Low sensitivity of the echocardiograph compared to contrast transcranial doppler in right-to-left shunt. Resolving the sources of plasma glucose excursions after a rat glucose tolerance test with deuterated water and [U-C-13] glucose.
Report of the Working Group of the Clinical Practice Guidelines Committee of the Spanish Society of Cardiology. Primary prophylaxis of early seizures after surgery for cerebral supratentorial tumors: recommendations of the Functional-Sterotactic Neurosurgery Study Group of the Spanish Society of Neurosurgery.
Proteostasis celular y enfermedades conformacionales
Publicaciones
Estructura, Neuroquímica y Plasticidad de los Circuitos Neuronales de la Corteza Cerebral
The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: a PET, histological and biochemical study. Distribution of GABAergic interneurons and dopaminergic cells in the functional areas of the human striatum.
Neuroinmunología Básica y Aplicada
Grupo 8 – Proyectos y Estudios de Resultados de Investigación Sanitaria Cardiovascular Organizados
A stratified analysis of location of TIMI graded bleeding and their impact on 12-month outcome in patients with ST-segment elevation myocardial infarction. Primary Endpoint Results of the EVOLVE Trial A Randomized Evaluation of a Novel Bioabsorbable Polymer-Coated Everolimus-Eluting Coronary Stent. Does new-onset atrial fibrillation have a real impact on the incidence of stroke after transcatheter aortic valve implantation.
A therapeutic option in patients with atrial fibrillation and esophageal varices and a high risk of bleeding.
Epidemiología Clínica y Prevención de Enfermedades Cardiometabólicas
Family history of diabetes and effectiveness of lifestyle counseling on the cardio-metabolic risk profile in individuals at high risk of type 2 diabetes: 1-year follow-up of the FIN-D2D project. Delaying progression to type 2 diabetes among high-risk Hispanic individuals is feasible in real-world primary health care settings using intensive lifestyle intervention. Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study.
A genome-wide approach that calculates body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Comparison of MDRD Study and CKD-EPI Study equations in estimating trends in estimated renal function at the population level: findings from the National FINRISK Study. Stratification of Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases.
Cerebrolysin in patients with acute ischemic stroke in Asia Results of a double-blind, placebo-controlled randomized trial. Should we consider cancer diagnosis in diabetic patients as a complication of diabetes, or are they iatrogenic consequences.
Epidemiología Cardiovascular y Nutrición
Dietary habits of the hypertensive population of Spain: in accordance with the DASH diet and the Mediterranean diet. Ambulatory blood pressure monitoring and development of cardiovascular events in high-risk patients included in the Spanish ABPM registry: the CARDIORISC Event study. Obesity-related eating behaviors are associated with low physical activity and poor diet quality in Spain.
Uric acid excretion in healthy subjects: a nomogram to assess the mechanisms of purine metabolic disorders. Major dietary patterns and risk of coronary heart disease in middle-aged individuals from a Mediterranean country: the EPIC-Spain cohort study. Prevalence of general and abdominal obesity in the adult population in Spain, the ENRICA study.
The diet of diabetic patients in Spain in accordance with the main dietary recommendations - a cross-sectional study. Protocol of a randomized cluster study to assess the effectiveness of the MOVI-2 program for obesity prevention in school children.
Unidad Metabólico-Vascular
Investigación en Nutrición y Alimentos Funcionales – NUTRINVEST
Coagulopatías y Alteraciones de la Hemostasia
Late avascular necrosis of the femoral head (ANFH) after nondisplaced percutaneous fixation of a femoral neck fracture in a hemophilic patient with inhibitors: an unreported association. Iatrogenic fracture of the proximal tibia as a complication of knee manipulation under anesthesia in a hemophiliac patient with ipsilateral stiff knee secondary to supracondylar femoral nonunion. Use of a plasma-derived FVIII product containing VWF (VWF/PD-FVIII) in primary or rescue induction of immune tolerance in patients with hemophilia A and inhibitors.
Successful induction of immune tolerance in patients with hemophilia A and inhibitors treated with a plasma-derived FVIII product containing von Willebrand factor: A large, international, multicenter, retrospective study.
Fisiología y Farmacología Vascular
SIDA y Enfermedades Infecciosas
Evaluation of the cost of Transient Elastography (FibroScan(R)) in the diagnosis of liver fibrosis in HIV patients with hepatitis C virus. Community-acquired methicillin-resistant Staphylococcus aureus skin and soft tissue infections in Madrid: prevalence study. Consensus paper from GESIDA and SPNS (Spanish Secretariat for the National Plan on AIDS) on combined antiretroviral treatment in adults infected with human immunodeficiency virus (January 2012).
Socio-demographic factors associated with the progression of HIV infection and the impact of HAART in a cohort of seroconverters in Madrid. Response to combination antiretroviral therapy by gender and origin in a cohort of naive HIV-infected patients: the GESIDA-5808 study. Detectable viral load impairs immunosenescence features of CD8 T-cell subsets in vertically HIV-infected children.
HIV replication, inflammation, and the effect of initiation of antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunction. Once-daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naïve adults with HIV: planned 48-week interim results from SPRING-1, a phase 2b, randomized, dose-escalation trial. Potent and sustained antiviral response of raltegravir-based highly active antiretroviral therapy in HIV type 1-infected children and adolescents.
Programs to optimize the use of antibiotics (PROA) in Spanish hospitals: consensus document GEIH-SEIMC, SEFH and SEMPSPH. Interleukin-6 and C-reactive protein levels after 3 years of treatment with darunavir/ritonavir monotherapy or darunavir/ritonavir plus two nucleoside reverse transcriptase inhibitors in the MONET trial. Incidence of rash in the 96-week analysis of the combined Phase III randomized double-blind ECHO and THRIVE trials.
Antiretroviral therapy (ART) regulates neural cell adhesion molecule (NCAM) and CX3CL1/MCP-1 levels in HIV-1 infected patients monitored through 48 weeks of treatment: (CXCL12/CX3CL1) chemokines regulate NCAM and prevent gp120 neurotoxicity. Registry of the Spanish network for systemic sclerosis: clinical pattern according to cutaneous subsets and immunological status.
Microbiología Molecular
Inmuno-Reumatología
Lack of association between the CXCL12 rs501120 polymorphism and cardiovascular disease in Spanish patients with rheumatoid arthritis. Ultrasound-guided arthrocentesis and joint injection practice, including training and implementation, in Europe: results of a survey of experts and scientific societies. The C677T polymorphism in the MTHFR gene is associated with methotrexate toxicity in a Spanish rheumatoid arthritis population.
Association study of BAK1 gene polymorphisms in Spanish rheumatoid arthritis and systemic lupus erythematosus cohorts. Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets. Changes in serum PINP during teriparatide therapy correlate with improvements in vertebral strength as assessed by finite element modeling in men with glucocorticoid-induced osteoporosis.
Teriparatide and risedronate in glucocorticoid-induced osteoporosis in men: 18-month results of the EuroGIOPS trial.
Respuesta Inmune Innata
Diagnóstico y Tratamiento de
Kidney transplantation in a patient with atypical hemolytic uraemic syndrome with high levels of antifactor h antibodies.
Fisiopatología Linfocitaria en Inmunodeficiencias
Characterization of Gamma Delta T lymphocytes in TAB(-)T Gamma Delta plus B plus NK plus scid due to leaky CD3D mutations.
Enfermedades Respiratorias
Regulación de la Expresión Génica por Hipoxia
Nefrología
Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses the epithelial-to-mesenchymal transition of mesothelial cells. Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study the hepatitis C virus cycle. Biological role, clinical significance and therapeutic potential of the recently discovered metabolic hormone fibroblast growth factor 21.
Neonatología
Envejecimiento y Fragilidad en las Personas Mayores
Hepatología Molecular
Instituto de Genética Médica y Molecular (INGEMM)
A novel dominant hyperekplexy mutation Y705C alters the trafficking and biochemical properties of the presynaptic glycine transporter GlyT2. Identification of the first recurrent PAR1 deletion in Leri-Weill dyschondrosteosis and idiopathic short stature reveals the presence of a novel SHOX enhancer. An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease.
Functional characterization of MODY2 mutations highlights the importance of fine regulation of glucokinase and its role in glucose sensing. Variations in RAS-MAPK genes in 200 Spanish patients with Noonan and other neuro-cardio-facio-cutaneous syndromes.
Implicación de los sistemas Glicérgico y Glutamatérgico en patologías del Sistema Nervioso
Genética molecular de las Distroglinopatías
Oncología Traslacional
A cross-market cost comparison of erlotinib versus pemetrexed for first-line maintenance treatment of patients with locally advanced or metastatic non-small cell lung cancer. PTRF/Cavin-1 and MIF proteins are identified as biomarkers for non-small cell lung cancer by label-free proteomics. Severe toxicity caused by sorafenib in hepatocellular carcinoma is consistent with data from renal cell carcinoma.
Long-term survivors with advanced non-squamous non-small cell lung cancer (NSNSCLC) treated with first-line (1L) chemotherapy (CT) plus bevacizumab (B) and maintenance (MTC) B. Sequential therapy in metastatic renal cell carcinoma: pre-clinical and clinical rationale for choosing a second- or follow-up therapy with a different mechanism of action.
Terapias Experimentales y Biomarcadores en Cáncer
Investigación en Otoneurocirugía
Anatomía Patológica. Cáncer de Mama y Ginecológico
The Clinicopathological Features of YWHAE-FAM22 Endometrial Stromal Sarcoma: A Histologically High-Grade and Clinically Aggressive Tumor.
Mecanismos de Progresión Tumoral
A role for the TGF beta/BMP co-receptor Endoglin in the regulation of epidermal stem cell function.
Modelos Animales y Celulares para la Detección y Caracterización de Células Madre
Faecal calprotectin in allogeneic stem cell transplantation for the diagnosis of acute graft-versus-host disease. Non-canonical residues of the marginally stable monomeric ubiquitin conjugase from goldfish are involved in binding to the C terminus of ring 1B.
Cirugía de las Malformaciones Congénitas
Cirugía Experimental
Comprehensive characterization of functional activities of pressurized and ultrasound-assisted liquid extracts from Chlorella vulgaris.
Fisiopatología Ósea y Biomateriales
Terapia Celular y Genometástasis
Ingeniería Celular
Farmacología Clínica
Grupo de Investigación sobre el Diagnóntico y Tratamiento de las Enfermedades
Investigación y Diagnóstico de Enfermedades Metabólicas Hereditarias
Investgación de Cirugía OsteoArticular - GICOA
In vitro assessment of Staphylococcus epidermidis and Staphylococcus aureus adhesion on TiO2 nanotubes on Ti-6Al-4V alloy. Histomorphometry of the ligaments using a generic image processing software, a new strategy for semi-automated measurements. Mullins influences behavior under compression in micelle-templated silica and micelle-templated silica/agarose systems.
Oftalmología
Ginecología y Obstetricia
Urgencias y Emergencias
