[PDF] Top 20 Análisis de la comunicación de emergencias en Twitter. El caso del ébola en España
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Effects of inhibitors of apoptotic pathways in Parkinson's disease models
... Parkinson’s disease is a movement disorder primarily characterised by rigidity, tremor, and bradykinesia (reviewed in Marsden ...Parkinson’s disease is a loss of catecholaminergic neurones in various areas ... See full document
15
LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
... LRRK2 inhibitors in some models, but replication with the newer genera- tion of highly potent and selective inhibitors is ...preclinical models of PD themselves are not ideal and advances in ... See full document
10
Rasagiline in treatment of Parkinson’s disease
... symptomatic effects of drug therapy that confound outcomes, in combination with lack of validated surrogate disease markers (LeWitt 2006; Biglan and Ravina 2007; Hung and Schwarzschild ...Parkinson’s ... See full document
7
Original Article Dysregulated pathways identification analysis in Parkinson disease based on attractor of within-pathway effects and crosstalk inter-pathways
... Parkinson’s disease patients and 23 healthy controls were collected from E-GEOD- 16561 ...Linear Models for Microarray Data (LIMMA) was then used to preprocess ... See full document
5
Inhibition of Parkinsonian tremor with cutaneous afferent evoked by transcutaneous electrical nerve stimulation
... In this paper, we tested the hypothesis that tremor could be suppressed in subjects with PD by disrupting the corti- cospinal transmission of descending tremor signals by means of inhibitory effects of cutaneous ... See full document
40
Stabilometric analysis in individuals with parkinson`s disease
... (1) Parkinson and 7 women) with a mean age of ...(bilateral disease, without impairment of balance), 6 in stage ...bilateral disease, retropulsion) and 8 in stage 3 (mild to moderate disease, ... See full document
143
Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis
... The effect of the five chelators on intracellular p53 activity was examined with reference to p53-dependent apoptosis in irradiated MOLT-4 cells. The results of the dye-exclusion test as a method for determining cell ... See full document
29
Sleep disorders in Parkinson’s disease
... that sleepiness is common in PD and may be associated with the disease itself, or caused by sleep disorders or medications. Because EDS and somnolence may occur during the initial titration of dopaminergic ... See full document
110
Review: management of Parkinson's disease
... Parkinson’s disease (PD) is a neurodegenerative disorder, initially characterized by a loss of dopaminergic neurons in the substantia nigra that spreads over the course of the disease to almost the whole ... See full document
12
Botulinum toxin for drooling in Parkinson s disease
... Estimates of prevalence of drooling in people with PD range from 10% to 84% (Nicaretta 2008; Ozdilek 2012, respectively), with the wide variation in the estimates due to the lack of a standard definition of drooling and ... See full document
7
Experiences of fear of falling in persons with Parkinson’s disease – a qualitative study
... This indicates that interventions targeting fear of falling need to be individually tailored for persons with Parkinson ’ s disease and should focus on several aspects, such as Parkinson[r] ... See full document
15
Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson’s disease
... side effects of tapentadol ER and, at each visit, they were asked whether they had experienced any gastrointestinal side effects such as nausea, vomiting, and constipation, and/or central nervous system ... See full document
5
Recent advances in rehabilitation for Parkinson’s Disease with Exergames: A Systematic Review
... transfer effects between cognitive and motor skills, for example, the positive effects of cognitive training in physical symptoms such as freezing of gait ... See full document
18
Quantitative assessment of perceptual, motor and cognitive function in Parkinson's disease and their contribution to freezing of gait
... visual cues generated by VR glasses while the subject walked a set path with synchronous 64-‐channel EEG recording. They found that the patient who responded to visual cues had reduced power and increased information ... See full document
155
Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
... EAE models, preventing the clinical relapses, but do not control pro- gressive disease [37], indicating that mechanisms other than myelin autoimmunity, such as autoimmunity to neur- onal proteins, are ... See full document
88
<p>Validation study of the Parkinson’s Fatigue Scale in advanced Parkinson’s disease</p>
... Non-motor Symptoms Scale (NMSS). 35 The NMSS is a 30-item instrument used to evaluate the burden of non- motor symptoms in PD. This scale is divided into nine domains: cardiovascular, sleep/fatigue, mood/apathy, percep- ... See full document
6
Investigation of Orally Administered Small Molecule Inhibitors of Caspase-3 in Murine Models of Apoptosis
... tissue extract with dose dependent increase in exposure levels both in plasma and liver. Because of its irreversible nature as well as selectivity over cysteine peotease, compound 3D could offer advantages specifically ... See full document
13
Neuroinflammation and fractalkine signaling in Alzheimer’s disease
... out models and neurodegenerative diseases Generation of a reporter mouse, replacing endogenous Cx3cr1 with a green fluorescent protein (GFP) re- porter under control of the Cx3cr1 promoter, demon- strated that ... See full document
37
Effects of deep brain stimulation amplitude on motor performance in Parkinson’s disease
... neurological disease aside from Parkinson’s disease; psychotic illness or chronic psychiatric disorder; history of drug dependence or intellectual impair- ment; history of cerebral insult (causing delayed ... See full document
8
Urological dysfunctions in patients with Parkinson’s disease: clues from clinical and non-invasive urological assessment
... Diagnosis of PD was made according to the U.K. PD Brain Bank criteria. PD patients suffering from diseases known to influence the urinary function, i.e. cognitive impairment, major depression and other psychiatric dis- ... See full document
55
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