[PDF] Top 20 Caracterização polínica do mel de Trás-os-Montes e Alto Douro
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Effect of CYP3A5 polymorphism on liver function and tacrolimus pharmacokinetics after conversion to a once-daily tacrolimus formulation in stable liver transplant patients
... in liver transplantation (LT) is well established ...its pharmacokinetics and pharmacodynamics vary considerably at both intraindividual and interindividual level; hence, establishing an empirical dosage ... See full document
56
Influences of Donor and Recipient Gene Polymorphisms on Tacrolimus Dosing and Pharmacokinetics in Asian Liver Transplant Patients
... of CYP3A5 expressors (38% among donors and 47% among reci- pients in this study, 51% in study by Loh PT, et al [8], genotyping could be cost-effective instead of merely ad- justing tacrolimus dose according ... See full document
45
Role of tacrolimus prolonged release in the prevention of allograft rejection
... solid-organ transplant recipient begins with prevention of rejection and achieving a balance between insufficient and excessive ...Standard tacrolimus therapy for prevention of solid-organ transplant ... See full document
11
The pharmacokinetics of valganciclovir prophylaxis in pediatric solid organ transplant patients at risk for Epstein–Barr virus disease
... This study was conducted at the University of Minnesota and the General Clinical Research Center. The University of Minnesota Institutional Review Board approved the study. Written informed consent was obtained from ... See full document
11
Original Article Switch of immunosuppressant therapy from tacrolimus to cyclosporine in 30 liver transplant patients who developed hyperbilirubinemia
... Thirty patients with persistent post- operative hyperbilirubinemia had an average plasma bilirubin concentra- tion of ...30 patients, 23 had elevated plasma concentration of transaminases and exhibited ... See full document
139
Investigation of clinical interaction between omeprazole and tacrolimus in CYP3A5 non-expressors, renal transplant recipients
... Genomic DNA was extracted from the 200 µ L ethylene- diaminetetracetic acid-treated whole blood sample with the use of QIAamp DNA Blood kit (QIACEN GmbH). CYP3A5 genotyping was performed with PCR followed by ... See full document
21
Cyclosporin A, but not tacrolimus, negatively affects the hepatic extraction fraction of hepatobiliary scintigraphy in liver transplant recipients
... negative effect has not been proved in scintigraphy with humans so ...of patients, receiving either CSA or tacrolimus (TAC) with the purpose of evaluating a possible diverging effect of these ... See full document
29
A Review on Pharmacology of Tacrolimus In Renal Transplant Patients
... organ transplant of a kidney into a patient with ESRD (End stage renal ...renal transplant recipients are on dialysis (peritoneal or hemodialysis) at the time of transplantation ...[5]. Transplant ... See full document
5
Case report: inability to achieve a therapeutic dose of tacrolimus in a pediatric allogeneic stem cell transplant patient after generic substitution
... Background: Tacrolimus is an immunosuppressive drug that is used to lower the activity of the patient ’ s immune system to prevent organ ...generic tacrolimus formulations especially in ...for ... See full document
5
Effects of Cholestasis on Whole Blood Concentration of Tacrolimus, an Immunosuppressant, in Living Related Liver Transplant Recipients
... s. After centrifugation for 5 min at 12,000 × g, the supernatant was applied to the solid-phase extraction cartridges and subsequently washed with 2 mL of ion- exchanged ... See full document
40
A novel approach for prediction of tacrolimus blood concentration in liver transplantation patients in the intensive care unit through support vector regression
... The roots of SVM lie in the statistical learning theory [29], which describes properties of learning machines which enable them to generalize well to unseen data. During the 1990s, SVM was developed by Vapnik and ... See full document
199
Predicting tacrolimus concentrations in children receiving a heart transplant using a population pharmacokinetic model
... The described population PK model structure was used to investigate the number of samples required to predict an individual’s future tacrolimus concentrations. The first step in this analysis was to manipulate the ... See full document
9
Treatment of acute antibody-mediated rejection using Rituximab
... (ESRD) patients is ...All patients who underwent renal transplantation from 2009 to 2014 in Chamran and Labbafinejad centers ...these patients further receiving conventional therapy AMR ... See full document
6
<em>CYP3A5</em> genotype-based model to predict tacrolimus dosage in the early postoperative period after living donor liver transplantation<div><br /></div>
... the pharmacokinetics following liver transplantation differs depending on whether the donor was a living or cadaveric ...recipient’s CYP3A5 genotype has a greater influence than the donor’s ... See full document
8
Topical tacrolimus as treatment of atopic dermatitis
... 782 patients (median age, 22 years; range 2–72) who remained in the study for up to 4 ...the patients discontinued the study prematurely; the median follow-up period was 1422 ...median tacrolimus ... See full document
36
Comparing the Effect of Propofol and Sevoflurane on Hemodynamics and Coagulation Status during Liver Transplant Anesthesia and Hepatic and Renal Function of the Patients after Liver Transplant
... All patients in group 1 were anesthetized with inhalation of sevoflurane and patients in group 2 were anesthetized with the IV injection of ...45. Patients were monitored by NIBP, ECG, CO – Oximetry ... See full document
10
Tacrolimus ointment in the management of atopic dermatitis
... and patients need a treatment that is safe and effi cacious when applied continuously or intermittently over a prolonged period of ...immunomodulator, tacrolimus ointment, provides an alternative to topical ... See full document
14
Original Article The influence of CYP3A4 and CYP3A5 gene polymorphism on individualized medication of FK506 and hepatorenal function after liver transplantation
... end-stage liver diseases, and the immunosuppressi- on is the key factor of prog- ...rejection after transplanta- tion. As FK506 has strong firstpass effect and low oral bioavailability with an aver- ... See full document
13
Evaluating the efficacy, safety and evolution of renal function with early initiation of everolimus facilitated tacrolimus reduction in de novo liver transplant recipients: Study protocol for a randomized controlled trial
... Month 12 after baseline. The null hypothesis is tested with analysis of covariance with treatment, center, HCV class (positive/negative), and MELD (≤30 vs >30) as factors, and eGFR at Visit 1 (baseline) as a ... See full document
15
Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients
... points. Patients who did not undergo biopsy but who had serum alanine aminotransferase (ALT) ...In patients with elevated liver enzyme, biopsy was performed if there was no improvement after ... See full document
10
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