[PDF] Top 20 Educação para sustentabilidade em administração: uma análise das concepções de estudantes da UFPB
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Regulation of murine NK cell exhaustion through the activation of the DNA damage repair pathway
... of NK cells that were present on the salivary glands, a site where the infection has been reported to persist for months (Supplemental Figure 5) and where there is not NK development or recruitment from the ... See full document
177
Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... as DNA damage-induced breaks, repair mechanisms like non-homologous end joining (NHEJ) are able to join any two dysfunctional chromosomal ends and lead to chromosomal fusions by recombination ... See full document
5
PubMedCentral-PMC5128917.pdf
... to DNA damage is essential for tumor ...p53-dependent cell cycle arrest and apoptosis for tumor suppression, recent studies have suggested that other areas of p53 regulation, such as ... See full document
275
<p>The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration</p>
... stem cell exhaustion, and altered intercellular ...increased DNA damage accumulation was regarded as a beginning of cellular senescence and was related to abnormal expression of in fl ammatory ... See full document
46
Review Article The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis
... the murine double minute 2 (MDM2) oncoprotein, however, is the most criti- cal negative regulator for p53 activity and the most extensively studied p53 E3 ligase ...the DNA damage induc- ing factors ... See full document
115
Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway
... by DNA double-strand breaks (DSBs). In DDR process, ATM is activated through autophosphotylation of serine 1981, which subsequently activates a range of down- stream targets involved in cell cycle ... See full document
8
A Novel Histone Crosstalk Pathway Important for Regulation of UV-Induced DNA Damage Repair in Saccharomyces cerevisiae
... UV damage, potentially altering expression of these genes during the damage ...regulates cell cycle pro- gression in the presence of DNA damage, our results indicate that UV-induced ... See full document
59
NK1 1 receptor ligation or tumour interactions prime NK cells for IL2 mediated metabolic and functional responses
... I would like to extend my deepest gratitude to Dr David Finlay for giving me this wonderful opportunity. Dr Finlay has been extremely supportive and encouraging throughout the PhD, not only guiding my project but giving ... See full document
21
Review on DNA damage, repair and DNA sequencing
... UV damage, alkylation/methylation, X-ray damage and oxidative damage are examples of induced ...Spontaneous damage can include the loss of a base, deamination, sugar ring puckering and ... See full document
11
HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines
... increasing cell proliferation, both of which can be reversed by inhibiting the PI3K pathway through an epigenetic mechanism involving histone H3K27 trimethylation ...GBM cell line; high ... See full document
5
Biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for Bax, Bcl 2, and Mcl 1 proteins
... prematurely activated apoptosis [33-36]. Animal studies have clearly shown that hemorrhage alone is sufficient to cause a variety of parenchymal alterations, including cellular damage and cytotoxic effects ... See full document
188
Bacteriophage T4 Mutants Hypersensitive to an Antitumor Agent That Induces Topoisomerase-DNA Cleavage Complexes
... Relationships between uvsX, uvsW, and mh The UvsXY recombination repair pathway is likely responsi- ble for repair of DNA damage resulting from mAMSA- induced topoisomeras[r] ... See full document
111
<p>Impact of the Activation Status of the Akt/mTOR Signalling Pathway on the Clinical Behaviour of Synovial Sarcoma: Retrospective Analysis of 174 Patients at a Single Institution</p>
... of cell transcription, translation, metabolism, proliferation, migration and ...PI3K/AKT/mTOR pathway plays an essen- tial role in tumour progression and that it is a pivotal factor in regulating tumour ... See full document
18
Investigations of DNA-Mediated Redox Signaling Between E.coli DNA Repair Pathways
... of DNA-mediated redox signaling for DNA lesion ...the cell during the dire need for proper DNA repair, likely due to non-specific enzyme ...the DNA lesion scanning system, ... See full document
185
PubMedCentral-PMC5837509.pdf
... kinetics, cell cycle, exposure durations (acute versus chronic), components within the media/surrounding fluid, and intracellular ...Regarding cell cycle, in vitro exposure systems typically evaluate ... See full document
13
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... the cell-free NER system that the presence of mismatched bases supports efficient DNA binding by XPC and stimulates subsequent dual inci- ...the DNA duplex and thus tend to es- cape detection by XPC ... See full document
28
HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?
... of DNA damage is a double- strand DNA break (DSB) ...a DNA repair-deficient cell ...lethal DNA lesion, cells have developed several mechanisms to repair DSBs, which ... See full document
8
Heparan sulfate mimetic PG545 mediated antilymphoma effects require TLR9 dependent NK cell activation
... using murine models of lymphoma, we determined that the antitumor effects of PG545 are critically dependent on NK cell activation and that NK cell activation by PG545 ... See full document
101
YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway
... causing cell death, including inhibition of Mcl1 expression and direct DNA damage ...the DNA damage response through an S phase arrest that can increase p53, Chk2, and H2AX ... See full document
60
Photoreactivation is the main repair pathway for UV induced DNA damage in coral planulae
... the repair of UV-induced CPDs are photoreactivation and nucleotide excision repair ...a DNA repair pathway present in all organisms apart from placental mammals (Kanai et ...to ... See full document
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