[PDF] Top 20 Eficiencia del servicio de transporte público urbano en la ciudad de Ibarra
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First-line treatment of EGFR-mutant non-small-cell lung cancer: the role of erlotinib and other tyrosine kinase inhibitors
... never-treated patients, the phase III LUX-Lung 3 trial was conducted, with results recently announced at the ASCO 2012 Annual Meeting. A total of 345 untreated patients with advanced adenocarcinoma with activating ... See full document
131
<p>Second-generation EGFR and ErbB tyrosine kinase inhibitors as first-line treatments for non-small cell lung cancer</p>
... 452 EGFR TKI-naïve patients with newly diagnosed or recurrent ( ≥ 12 months since prior treatment) NSCLC received either dacomitinib or ge fi tinib (Table ...both treatment arms (Table 1; Figure 3D), ... See full document
5
<p>Immunotherapy Combined with Chemotherapy as a Promising Therapy for a EGFR Exon 19 Deletion with MET Amplification Patient with Non-Small-Cell Lung Cancer: A Case Report</p>
... advanced non-small-cell lung cancer (NSCLC) patients with a mutant epidermal growth factor receptor (EGFR), EGFR tyrosine kinase inhibi- tors (TKIs) ... See full document
5
BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations
... Lung cancer is the leading cause of cancer related death in the developed countries and in Latin America, and non–small-cell lung cancer (NSCLC) accounts for most ... See full document
30
Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer
... alleviating cancer conditions. The current treatment paradigm has shifted to personalized treatment strategies with tyrosine kinase inhibitors (TKIs) or anaplastic lymphoma ... See full document
5
<em>EGFR</em> mutations as a prognostic and predictive marker in non-small-cell lung cancer
... Abstract: Non-small-cell lung cancer (NSCLC) has entered the age of individual treatment, and increasing point mutations of specific oncogenes and rearrangement of some ... See full document
5
The predictive role of pretreatment epidermal growth factor receptor T790M mutation on the progression-free survival of tyrosine-kinase inhibitor-treated non-small cell lung cancer patients: a meta-analysis
... after EGFR TKI failure poses a great challenge to physicians in terms of how best to manage this growing group of lung-cancer ...the EGFR TKI domain may offer the potential for over- coming ... See full document
5
Exploratory cohort study and meta-analysis of <em>BIM</em> deletion polymorphism in patients with epidermal growth factor receptor-mutant non-small-cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors
... after EGFR-TKIs treatment in advanced NSCLC EGFR- mutant patients than those without BIM ...and other concurrent genetic alterations are warranted to uncover more underlying biology of ... See full document
9
Three generations of epidermal growth factor receptor tyrosine kinase inhibitors developed to revolutionize the therapy of lung cancer
... the treatment with the first-generation EGFR TKIs, such as erlotinib and ...second-generation EGFR TKIs, such as afatinib, dacomitinib and neratinib, demonstrated promising activity ... See full document
9
EGFR-mutated lung cancer: a paradigm of molecular oncology
... multiple other ligands) to its extracellular domain, EGFR forms dimers with itself and other members of the ErbB family via specific dimerization domains [37,38], which induces conformational shifts ... See full document
7
EGFR with TKI-sensitive mutations in exon 19 is highly expressed and frequently detected in Chinese patients with lung squamous carcinoma
... Recently, tyrosine kinase inhibitors (TKIs) have been recommended as a first-line treatment for advanced non-small cell lung cancer (NSCLC), ... See full document
13
Efficacy of epidermal growth factor receptor inhibitors in combination with chemotherapy in advanced non-small cell lung cancer: A meta-analysis of randomized controlled trials
... The role of a combination of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy for non-small-cell lung cancer ... See full document
24
Role of erlotinib in first-line and maintenance treatment of advanced non-small-cell lung cancer
... express EGFR by inmunohistochemistry ...of EGFR, as well as the analysis of other different biomarkers (EGFR gene copy number by fluorescent in situ hybridization – FISH, EGFR and Kras ... See full document
15
Clinical efficacy of first-generation EGFR-TKIs in patients with advanced non-small-cell lung cancer harboring <em>EGFR</em> exon 20 mutations
... of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon ...of first-generation EGFR-tyrosine ... See full document
20
<p>Association Of Initial Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Treatment And EGFR Exon 19 Deletion With Frequency Of The T790M Mutation In Non-Small Cell Lung Cancer Patients After Resistance To First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors</p>
... Third-generation EGFR-TKIs such as osimertinib show good ef fi cacy in patients with T790M-positive NSCLC who acquire resistance to prior EGFR-TKI ...rst-generation EGFR-TKIs in the treatment ... See full document
6
Advances in target therapy in lung cancer
... a small, but statistically significant, survival advantage in one of the RCTs (table ...to EGFR-TKI: female sex, adenocarcinoma, being a nonsmoker and East Asian ...the tyrosine kinase of the ... See full document
46
Phase I/II study of erlotinib, carboplatin, pemetrexed, and bevacizumab in chemotherapy-naïve patients with advanced non-squamous non-small cell lung cancer harboring epidermal growth factor receptor mutation
... After EGFR TKI failure, cytotoxic chemotherapy is currently considered the second-line treatment in clinical practice; however, this treatment remains associated with a poor ... See full document
7
EGFR-TKI therapy for patients with brain metastases from non-small-cell lung cancer: a pooled analysis of published data
... of EGFR- TKI therapy in patients with brain metastases from ...these small prospective and retro- spective ...patients, EGFR-TKIs yield significant beneficial effects, with a pooled intracranial ORR ... See full document
13
Frequency of Epidermal Growth Factor Mutation Status and Its Effect on Outcome of Patients with Adenocarcinoma of the Lung
... of EGFR mutations is ethnicity-dependent, with a higher proportion in Asian popu- lation than in ...of EGFR mutations in our popula- tion with lung adenocarcinoma, and the effect of this mutation on ... See full document
61
Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas
... the EGFR. Initially, we used the double labeling of EGFR with Lamin B1 in all ...evaluate EGFR intranuclear ...the EGFR is found within the nucleus and also co-localizes with Lamin B1 (Figures ... See full document
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