[PDF] Top 20 El crecimiento potencial de la economía española
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Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models
... phosphorylated Akt [p-Akt], mTOR, phosphorylated mTOR [p-mTOR], ribosomal protein S6 kinase [p70S6K], phosphorylated p70S6K [p-p70S6K; 1:1,000] and β -actin [1:5,000]) from Cell Signaling (Danvers, MA, USA) ... See full document
5
Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice
... the activation of TAK1/NF-κB pathways ...protective effects through the enhancement of beta-amyloid protein degrad- ation and maybe is a potential candidate for AD treatment ...the AKT/mTOR ... See full document
16
Original Article The role of the PI3K/Akt/GSK-3β pathway in postoperative cognitive dysfunction in elderly rats
... that PI3K/AKT pathway is widely expressed in the central ner- vous system and its neuroprotection role has been well ...that PI3K/Akt pathway can inhibit neuronal apopto- sis ... See full document
51
Post-ischemic estradiol treatment reduced glial response and triggers distinct cortical and hippocampal signaling in a rat model of cerebral ischemia
... the PI3K/Akt survival pathway in ...with PI3K to phosphorylate and activate Akt ...in Akt phosphorylation at both Ser473 and Thr308 residues suggested a reduction in Akt ... See full document
18
<p>Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo</p>
... antiangiogenic effects. The protective effects of SFN against oxidative damage induced by toxic drugs have been demonstrated and were shown to be mediated by NF-E2-related factor 2 (Nrf2); therefore, it is ... See full document
10
Arsenite Activation of PI3K/AKT Cell Survival Pathway is Mediated by p38 in Cultured Human Keratinocytes
... the activation of cell surface components that may or may not be re- ...the activation of PI3K/AKT pathway is subsequent to the activation of cell growth factor receptor upon ... See full document
24
So Cheong Ryong Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non small cell lung cancer A549 cells
... the PI3K/Akt pathway is associated with resistance to chemo- therapeutic agents ...of Akt, and are related to proliferation and apoptosis ...the PI3K/Akt pathway ...the ... See full document
24
Mitogen-Activated Protein Kinase-Interacting Kinase Regulates mTOR/AKT Signaling and Controls the Serine/Arginine-Rich Protein Kinase-Responsive Type 1 Internal Ribosome Entry Site-Mediated Translation and Viral Oncolysis
... inverse effects on mTORC1 versus mTORC2 activity ...occur through several mechanisms, for exam- ple, via (mTORC1-driven) S6K activation and downstream phosphorylation of rictor ...off-target ... See full document
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<p>Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease</p>
... signaling pathway could trans- mit extracellular signals into the nucleus to affect cell fate, including cell proliferation, differentiation, survival, and ...transformation. Activation of this ... See full document
18
Buyang huanwu decoction promotes angiogenesis via vascular endothelial growth factor receptor 2 activation through the PI3K/Akt pathway in a mouse model of intracerebral hemorrhage
... rat models [48,49]. The effects of BYHWD on neurological outcome improvement and in- farction reduction in ischemic stroke have been reported ...pro-angiogenic effects of BYHWD may furthermore ... See full document
33
Targeting neuroinflammation in Alzheimer’s disease
... glial activation takes place with the aim of removing injurious ...phenotype. Activation causes, among other things, glial hypertrophy, astrocyte endfeet retraction, and gain of amoeboid microglial ... See full document
7
Original Article Lipopolysaccharide activated TLR4/NF-κB signaling pathway of fibroblasts from uterine fibroids
... To explore the relationship between reproduc- tive tract infection and fibroid, we first detect one receptor of pathogen-associated molecu- lar patterns (PAMPs), TLR4. Both immunofluo- rescence analysis and western blot ... See full document
15
The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
... in S phase (P = ...cells. PI3K/AKT/mTOR pathway components, PIK3CA, PIK3CD, AKT3, ECM1, GPCR, mTOR and PRKCB were increased but that the Nur77 and PTEN were decreased in A-H/S-H cells, ... See full document
197
Role of berberine in Alzheimer’s disease
... Alzheimer’s disease (AD) by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary ...basis through which berberine may retard oxidative stress and neuroinflammation to ... See full document
14
Original Article Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL
... patients. PI3K/AKT pathway, which is constitutively acti- vated, plays an important role in most tumor cells as a carcinogenic factor, including B-NHL [12 ...kinase AKT in ... See full document
81
Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?
... An increasing global incidence of ICC [5] has recently has- tened research in this field to understand the mechanisms underlying pathogenesis of this dreadful disease. Reviewing the mechanisms of ICC indicates ... See full document
7
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
... PTEN S-nitrosylation in the proliferation and survival of cells under conditions of metabolic stress, we performed clonogenic assays in PTEN null PC3 cells overexpressing EV, WT or SNO-resistant (C83S) PTEN in the ... See full document
17
Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways
... of S-phase cells. Through the use of inverted microscopy, Cell Counting Kit-8, and Transwell assays, we found that compared with parental 231 cells, 231/Gem cells displayed more morphologic projections, ... See full document
8
Activation of mTOR: a culprit of Alzheimer’s disease?
... biological effects including translation of mRNA via the phosphorylation of downstream targets (4E-BP1 and p70S6 Kinase), suppres- sion of autophagy (Atg13, ULK1), ribosome biogenesis, and activation of ... See full document
13
A vicious cycle between acid sensing and survival signaling in myeloma cells: acid-induced epigenetic alteration
... the PI3K-Akt signaling in MM cells while upregulating the pH sensor transient receptor potential cation channel subfamily V member 1 (TRPV1) in a manner inhibitable by PI3K ...acid-activated ... See full document
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