[PDF] Top 20 Estilo de vida y síndrome de burnout en el personal de salud de una clínica privada de Lima, 2014

... Moreover, given that the reduction in LVEF in the placebo group in this study was less than originally anticipated, the power of the study to detect between group differences was reduced. Accordingly, the apparent lack ... See full document

... drug induced myocardial damage becomes more significant in the wake of finding that dexrazoxane, an antioxidant that functions by chelating iron has significant cardio ...The role of routine cardiac ... See full document

... In 2018, Gupta and colleagues [10] studied 84 patients with leukaemia and lymphoma (41 and 43 patients, re- spectively). In contrast to the earlier study, this was a randomized, double-blind, controlled trial. All the ... See full document

... a role in the prevention of systolic dysfunction because the reason why this sub- group showed negative results was that two trials [5, 12] about metoprolol showed negative ...that nebivolol protected ... See full document

... Summary: Anthracycline antibiotics are among the most effective and widely used antineoplastic ...dose-related cardiotoxicity, whose precise mechanisms are not clear as ...principal role is possibly ... See full document

... radicals induced by ROS and chronic cellular apoptosis due to AC treatment, which may be, an important underlying mechanism leading to diffuse myocardial ...the role of fibrocytes in ACIC and whether early ... See full document

... of cardiotoxicity preclude reaching consensus regarding the role of sex as a risk factor in ...adult anthracycline-treated cancer patients, understanding the mechanisms of this significant sexual ... See full document

... in anthracycline-induced cardiotoxicity, which includes the ability of an iron chelator and dexrazoxane, to alleviate anthracycline-induced ... See full document

... cardioprotective role of RAS antagonists in the clinical setting of chemotherapy mediated ...an anthracycline based chemotherapy regimen, Dessi et ... See full document

... to anthracycline therapy has been shown to improve the chemotherapeutic re- sponse, but is also associated with a marked increase in the development of CHF [3], with the incidence of CHF increasing from 8% to 27% ... See full document

... to anthracycline chemotherapy and at least one echocardio- gram performed to assess cardiac function post- ...transient cardiotoxicity, [33] only echocardiograms recorded greater than 17 days after ... See full document

... Inflammation and relevance for biomarker profiling Inflammatory mediators play an important role in LV re- modeling. Major steps in this process include myocyte hypertrophy, [46] alterations in fetal gene ... See full document

... Cardiotoxicity is a rising issue connected to use of chemotherapy and radiotherapy in the treatment of neoplastic diseases. Early diagnosis during follow-up is of paramount importance, and careful surveillance is ... See full document

... Myocardial cytotoxicity induced by HCY and acrolein Assay results for MTT showed that exposures to CY, CEPM or 10 μM acrolein did not induce cytotoxic- ity. Myocardial cytotoxicity did ensue, however, after 24 and ... See full document

... of cardiotoxicity with the use of CCBs which include negative ionotropic effect, activation of rennin-angiotensin system and alteration in membrane calcium transport 61 ...and Cardiotoxicity: Adverse effect ... See full document

... effective anthracycline chemotherapeutic agent clinically used for treatment of several types of haematological malignancy and solid tumour ...Adriamycin- induced cardiotoxicity causes severe changes ... See full document

... While providing a mechanism to reconcile previous diverg- ing evidence, our results set the stage to direct future research and therapeutic interventions toward molecular target(s) pos- sibly different from lipid ... See full document

... explain why p53 signaling is almost universally perturbed in cancers by direct mutations or by mutations to proteins that regulate p53. p53 is the most commonly mutated gene in cancers, which has contributed to its ... See full document

... the role for HO-1 in mitochondrial fission may be an indirect function of exaggerated mitochon- drial injury in WT versus cs-HO-1 mice, these studies suggest a direct relationship between mitofusion and HO-1 ... See full document

... doxorubicin-induced cardiotoxicity is still not entirely clear although a diverse set of mechanisms have been proposed, including oxidative stress,[6] intracellular calcium overload,[7] mitochondrial DNA ... See full document