[PDF] Top 20 O sentido do trabalho: uma análise à luz das Gerações X e Y
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Transcriptional regulatory model of fibrosis progression in the human lung
... frozen lung was imaged using a high-resolution CT scanner (Siemens Somatom) and cut into 2-cm-thick slices along the transverse plane for ...lower lung regions for 6 samples per lung (Figure 1, A and ... See full document
9
Transcriptional trajectories of human kidney injury progression
... a transcriptional signature related to kidney injury, fibrosis, and chronic inflammation (Figures 3, A and B, and Supplemental Table ...the progression to fibrosis as a transitional process ... See full document
6
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis
... develop lung fibrosis, but how infection leads to fi- brosis remains ...of lung fibrosis ...with lung fibrosis [42], and we show in the current study that increased FN1 mRNA ... See full document
19
miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways
... suppress fibrosis while maintaining minimal off-target side ...in fibrosis that are all controlled by the same regulatory mechanisms could lead to methods to pharmacologically manipulate expression ... See full document
9
Origins of Transcriptional Transition: Balance between Upstream and Downstream Regulatory Gene Sequences
... promoter transcriptional transition during cell growth ...the regulatory gene sequence does not produce bimodal populations at the mRNA level, while it does when activated together through the coordina- ... See full document
7
Uncovering Transcriptional Regulatory Networks by Sparse Bayesian Factor Model
... BSCRFM model are considered to be correlated. To model the correlation between factors, a Dirichlet process mixture (DPM) prior [18] was placed on the ... See full document
71
In silico regulatory analysis for exploring human disease progression
... Using the known set of 15 targets for WT1, the SVM method expands the set to include 354 new targets (at Platt score P ≥ 0.95; see Methods The 15 training set target genes and original supporting references can be found ... See full document
17
Transcriptional Analysis of the Global Regulatory Networks Active in Pseudomonas syringae during Leaf Colonization
... target regulatory genes ahlR, aefR, salA, rpoS, algU, hrpL, and rpoN and used nonpolar deletion mutations in retS and gacS that were described previously ... See full document
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Identification of Prognostic Biomarker Signatures and Candidate Drugs in Colorectal Cancer: Insights from Systems Biology Analysis
... and transcriptional/post-transcriptional regulatory networks to identify reporter signaling and regulatory molecules; utilized functional overrepresentation and pathway enrichment analyses to ... See full document
98
In silico model-guided identification of transcriptional regulator targets for efficient strain design
... host [37]. Initially, it has been shown that lycopene can be produced in E. coli via mevalonate [38] and non-meva- lonate pathways [39]. However, with an increased inter- est for lycopene, alternative strategies are ... See full document
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Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin
... in human IPF is still ...rodent lung induced the upregulation of TGF-β1, a major pro-fibrotic growth factor, and lung fibrosis [14, ...BLM model of lung fibrosis ...severe ... See full document
20
The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles.
... A major transcriptional regulatory protein ICP4 of herpes simplex virus type 1 is associated with purified virions.. Association of a major transcriptional regulatory protein, ICP4, of h[r] ... See full document
22
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice
... critical fibrosis-inducing effect(s) occurs through other cells or other path- ...bleomycin model, cell types, including bone marrow–derived cells, epithelial cells, endothelial cells, and pericytes, may ... See full document
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The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy
... response is short lived, with the up-regulation of mRNA encoding pro-inflammatory cytokines and chemokines generally peaking between 3 - 9 hr. This rapid but short term activity is supported by evidence that intraperito- ... See full document
14
Transcriptional regulatory elements in the noncoding region of human papillomavirus type 6.
... Enhancer and promoter activities of HPV-6e and HPV-6g NCRs Activity" for plasmid: pTCS pTCS-6eABCD Transfection recipient cell line NIH 3T3 HOS HeLa CaSki C-33A pSV2cat pTCS-6gABCD 0.6..[r] ... See full document
19
Evolutionary and Functional Analysis of SlyA in Salmonella typhimurium
... SlyA is a transcriptional regulatory protein in S.typhimurium that is necessary for virulence. It was first identified by Libby et al. as being associated with a hemolytic phenotype when cloned into E.coli ... See full document
10
A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen synthesizing fibroblasts Detection of an altered fibroblast phenotype in lungs of patients with pulmonary fibrosis
... collagen. Lung biopsies from patients with fibrotic lung disease were stained with ...active fibrosis stained intensely with Anti-pC, while normal human lung was ...normal lung ... See full document
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Expression of the cystic fibrosis gene in adult human lung
... subpopulation of nonciliated cells. CFTR was expressed in the same distribution as the Clara cell marker CC10 in proximal bronchioles, however, expression was discordant in the more distal bronchioles and alveoli where ... See full document
8
A Transcriptional Regulatory Mechanism Finely Tunes the Firing of Type VI Secretion System in Response to Bacterial Enemies
... The combinatorial effect of vgrG2, vgrG3, and vgrG4 mutations indicated that Tde (a putative nuclease) and Tse (with unknown activity), the two cognate effectors whose secretion is facilitated by VgrG2 and VgrG3, ... See full document
47
Original Article miR-425 reduction causes aberrant proliferation and collagen synthesis through modulating TGF-β/Smad signaling in acute respiratory distress syndrome
... [24] van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O’Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, ... See full document
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