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Identification of a 40KD Protein Increased by HSV-2 Infection
... This work is protected against unauthorized copying under Title 17, United States C o d e M icroform Edition © ProQuest LLC.. ProQuest LLC.[r] ... See full document
18
Stress Hormones Epinephrine and Corticosterone Selectively Modulate Herpes Simplex Virus 1 (HSV-1) and HSV-2 Productive Infections in Adult Sympathetic, but Not Sensory, Neurons
... also increased replication and the release of infectious virus progeny by HSV-1 during productive infection at two different ...G protein, which stimulates adenylate cyclase and causes an ... See full document
169
Development of a Glycoprotein D-Expressing Dominant-Negative and Replication-Defective Herpes Simplex Virus 2 (HSV-2) Recombinant Viral Vaccine against HSV-2 Infection in Mice
... productive infection: immediate-early ( ␣ ), early (  ), and late ( ␥ ), with late genes being further divided into ␥ 1 and ␥ 2 ...viral protein, and DNA synthesis and is activated by the virion- ... See full document
236
In Vivo Modulation of Vaccine-Induced Immune Responses toward a Th1 Phenotype Increases Potency and Vaccine Effectiveness in a Herpes Simplex Virus Type 2 Mouse Model
... from HSV-2 infection are still under ...the HSV-2 mouse model system and to further explore DNA vaccine ...from HSV-2 infection, we codelivered the DNA expression ... See full document
55
Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages
... viral infection is initiated by the cells of the innate immune response, including ...of HSV-1-infected human primary macrophages using high-throughput quantitative pro- ...upon HSV-1 ... See full document
34
Immunization with Herpes Simplex Virus 2 (HSV-2) Genes plus Inactivated HSV-2 Is Highly Protective against Acute and Recurrent HSV-2 Disease
... recurrent HSV-2 disease and shedding in humans has been difficult, and the use of animal models has thus far shown only limited success for the rational design of an effec- tive HSV-2 vaccine ... See full document
169
Herpes Simplex Virus Type 2 Glycoprotein G-Negative Clinical Isolates Are Generated by Single Frameshift Mutations
... gG-2-negative HSV-2 strains had been isolated. H. pomatia lectin-purified gG-2 (100 g/ml), coated at a 1:6,000 dilution in carbonate buffer (pH ...gG-2-negative HSV-2 ... See full document
47
Herpes Simplex Virus 1 Reactivates from Autonomic Ciliary Ganglia Independently from Sensory Trigeminal Ganglia To Cause Recurrent Ocular Disease
... acute infection (1 to 14 dpi), HSV-2 expressed higher levels of TK in TG, SCG, and CG than did HSV-1, correlating with the more severe acute disease symptoms observed in the guinea ...TG, ... See full document
39
Loss of the Type I Interferon Pathway Increases Vulnerability of Mice to Genital Herpes Simplex Virus 2 Infection
... following infection with ...genital HSV-2 infection ...following HSV-2 ...to infection with HSV-2 (2,000 ...the HSV-specific CD8 ⫹ T cell (CD8 ⫹ ... See full document
66
Herpes simplex virus 2 (HSV 2) type specific antibody correlates of protection in infants exposed to HSV 2 at birth
... primary infection, in 3 of 9 infants of women with nonprimary first episode infection, and in none of the 27 infants of women with recurrent ...to HSV-2 proteins gG-2, VP5, and ICP35 ... See full document
67
Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells.
... We have found that i the cytoplasmic levels of six different mRNAs decline during HSV infection, though not all at the same rate; ii infection with HSV-2 causes a more rapid decrease in [r] ... See full document
1
Use of Acyclovir for Suppression of Human Immunodeficiency Virus Infection Is Not Associated with Genotypic Evidence of Herpes Simplex Virus Type 2 Resistance to Acyclovir: Analysis of Specimens from Three Phase III Trials
... UL23 gene. The frequency of ACV resistance is increased in ACV-treated, immunosuppressed individuals and may reach 5% (25). However, ACV resistance has also occasionally been documented in immunocompetent persons ... See full document
151
Initial interaction of herpes simplex virus with cells is binding to heparan sulfate.
... to determine whether of one DISCUSSION Our results demonstrate that the initial step in infection of HEp-2 cells by HSV-1 and HSV-2 is binding of virions to Downloaded from http://jvi.as[r] ... See full document
21
Neonatal Herpes Simplex Virus Infections: New Data, Old Conundrum
... 1. Kimberlin DW, Lin CY, Jacobs RF, et al; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Natural history of neonatal herpes simplex virus infections in the acyclovir era. ... See full document
14
High prevalence of herpes simplex virus (HSV) type 2 co infection among HIV positive women in Ukraine, but no increased HIV mother to child transmission risk
... between HSV-2 serostatus and MTCT after adjusting for maternal HIV viral load be- cause of limited viral load testing: of the 37 HIV- infected infants, 23 were born to women with no antenatal HIV RNA ... See full document
116
Locations of herpes simplex virus type 2 glycoprotein B epitopes recognized by human serum immunoglobulin G antibodies.
... FIG. 2. Mapping of the GB2-SS2 epitope recognized by HSV-2 ...different HSV-1 2 /2 1 subjects. Lane V contains the protein expressed by the pATH expression ...GB2-SS2 ... See full document
Rates of Reactivation of Latent Herpes Simplex Virus from Mouse Trigeminal Ganglia Ex Vivo Correlate Directly with Viral Load and Inversely with Number of Infiltrating CD8+ T Cells
... tifying HSV-2-specific IFN- ␥ -expressing CD8 ⫹ T cells as previously described ...with HSV-2 strain 333 at a level of 3 PFU/cell for 5 ...with HSV-2 in the presence of 10 g of ... See full document
121
STAT4 Regulates Antiviral Gamma Interferon Responses and Recurrent Disease during Herpes Simplex Virus 2 Infection
... in HSV-2 immunity has been well described in murine models of genital HSV-2 infection, in which IFN-␥ (14, 25, 30), and T-bet expression (39) are critical for viral clearance and ... See full document
137
Risk Factors for HSV 2 Infection among Sexual Partners of HSV 2/HIV 1 Co Infected Persons
... Prevention HSV/HIV Transmission Study, a randomized clinical trial of suppressive acyclovir therapy to reduce sexual HIV-1 transmission from HSV-2/HIV-1 dually-infected women and men to their HIV-1 ... See full document
14
Performance of HerpeSelect and Kalon Assays in Detection of Antibodies to Herpes Simplex Virus Type 2
... of HSV-2 antibodies in sera associated with nonprimary first clinical episodes of HSV-2 infection showed that HerpeSelect detected HSV-2 serocon- version more frequently ... See full document
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