[PDF] Top 20 Recursos Educativos Abiertos en las universidades españolas: estado de la cuestión
Has 10000 "Recursos Educativos Abiertos en las universidades españolas: estado de la cuestión" found on our website. Below are the top 20 most common "Recursos Educativos Abiertos en las universidades españolas: estado de la cuestión".
Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
... The mouse was placed in the middle of the open field and was free to explore ...the mouse stopped running and start licking, chewing and scratching at its ...each mouse was subjected to a 10-minute ... See full document
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Neuroprotective effects of a triple GLP 1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease
... astrocytes is much reduced by the novel TA, similar to single GLP-1 or GIP receptor agonists (Duffy and Holscher, 2013; Ji et al., 2016a; McClean et al., 2011). Levels of the peroxidized lipid 4-HNE that also acts as a ... See full document
17
Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
... Ermund, A., Schütte, A., Johansson, M.E., Gustafsson, J.K., Hansson, G.C. 2013. Studies of mucus in mouse stomach, small intestine and colon. I. Gastrointestinal mucus layers have different properties depending on ... See full document
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A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease
... each mouse was allowed 3 min to explore the objects (familiarisation ...each mouse was given 3 min to explore the ...The D 2 discrimination index was used to present results. The D 2 index is ... See full document
5
Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models
... AD model fly lines, such as human APP/ BACE transgenic line EAPP/BACE, single and double copy A β lines (EA β , EA β ; A β ), and A β mutant line E22G, and observed reduced longevity in all four (Figure ... See full document
5
An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model
... was subtracted in order to merge the data from different replicates. Proteins with proteoforms were deleted during data analysis. Principal component analyses (PCA) were performed to assess sample quality when comparing ... See full document
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Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model
... animal model (which is associated with brain regional limitations) or use a different cell type (monocytes) or dif- ferent age ...transgenic mouse model that shows ... See full document
10
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
... ’ s disease (AD) is a highly malignant neuro- degenerative process characterised by anomalous intra- neuronal and extracellular accumulation of b -amyloid protein (A b ) [27] and hyperphosphorilated ... See full document
5
Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study
... BIOMARKAPD: Biomarkers for Alzheimer ’ s disease and Parkinson ’ s disease; BMI: Body Mass Index; CANTAB: Cambridge Neuropsychological Test Automated battery; CCI: Cognitive ... See full document
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Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
... the Biomarkers for Alzheimer ’ s disease and Parkinson ’ s disease (BIOMARKAPD) project of the EU Joint Programme – Neurodegenerative Disease Research ...’ s ... See full document
8
Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
... cipir is still a relatively new tracer; thus, only a few antemor- tem vs postmortem comparisons have been reported, and its binding properties are not yet fully understood. Factors that could affect the accuracy of the ... See full document
6
Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort
... letters D-A-T in The Netherlands or F-A-S in English and a total time of 60 s per letter (one point for each correct non-repeated ...participant’ s semantic fluency by re- quiring them to ... See full document
6
Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s disease
... transgenic Alzheimer ’ s disease mice; 7,8-DHF, 7,8-dihydroxyflavone; Ach, acetylcholine; AD, Alzheimer ’ s disease; APOE ε 4, apolipoprotein E ε 4; APP, amyloid β ... See full document
8
FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice
... transgenic mouse models of AD is a powerful tool to assess Aβ tracer properties in vivo ...of mouse model seems to play a crucial role as they differ in extent and type of Aβ pathology ...new ... See full document
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Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration
... or tau (FTLD-tau) [2, 3]. While each molecular path- ology is associated with mutations in specific genes (e.g., GRN , C9orf72 , MAPT ) there is clinical overlap across pathologies and with AD [4 – 6]. Clinical diagnosis ... See full document
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Moderating effects of sex on the impact of diagnosis and amyloid positivity on verbal memory and hippocampal volume
... positive biomarkers such as A + ...other biomarkers, possibly with an ap- proach that places heavier weight on biomarkers such as A + early on, could increase diagnostic ... See full document
6
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
... chromosomes and both are strong hits for pelvic organ prolapse. While diseases of the nervous system can cause pelvic organ prolapse, it is unlikely related to the ptau / Aβ42 relationship but may suggest that these two ... See full document
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Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
... observed 5 heterozygous individuals in total. Four were LOAD cases, all of whom carried the APOE e 3/ e 4 genotype. Only a single cognitively normal control carried the TTC3 variant (0.018%). This individual was last ... See full document
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Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia
... of Alzheimer ’ s disease (EP000002068151A1); Immunoglobulinbound A β and immunoglobulins-binding A β peptides in diagnosis and therapy of Alzheimer ’ s disease ... See full document
16
A novel dual GLP 1/GIP receptor agonist alleviates cognitive decline by re sensitizing insulin signaling in the Alzheimer icv STZ rat model
... good effects in animal models of AD by reducing memory loss, synapse loss and amyloid plaque load [16-19], decrease the hyperphosphorylation of τ protein [20-23], exert anti-inflammatory function [24-26] and ... See full document
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