[PDF] Top 20 Semejanzas y diferencias entre el Movimento 5 stelle y Podemos
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The role of stromal cancer-associated fibroblasts in pancreatic cancer
... dominantly cancer-associated fibroblasts (CAFs), immune cells, and a rich extracellular matrix (ECM), all of which interact closely with the tumor cells and offer potential therapeutic targets ... See full document
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The Role of Hyperinsulenemia as a Risk Factor for Pancreatic Cancer
... Background: Pancreatic cancer is associated with a very severe prognosis and identification of risk factors is ...a role of high insulin levels in causing pancreatic ...and ... See full document
16
MiR-21-mediated Metabolic Alteration of Cancer-associated Fibroblasts and Its Effect on Pancreatic Cancer Cell Behavior
... Reports have shown that pancreatic stellate cells exhibit high expression of miR-21, which plays an important role in tumor cells. To test whether miR-21 was involved in the reverse Warburg effect process ... See full document
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Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis
... breast cancer [11, 12], hepatocellular cancer [13], lung cancer [14] and colorectal cancer ...functional role of p-ERK1/2 in pancreatic cancer and the therapeutic ... See full document
8
Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway
... important role in maintaining the self-renewal capacity and pluripotency of hESCs [9, ...breast cancer, prostate cancer and endometrial cancer [2, ...with cancer growth and progression ... See full document
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Molecular characterization of cancer-associated fibroblasts isolated from human colorectal cancer as a major stromal cell component promoting metastasis
... Colorectal cancer (CRC) remains a disease with poor prognosis and limited overall 5-year survival rate, which highlights a clear clinical need for novel treatment ...The stromal ... See full document
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A Prospective Study of Plasma Adiponectin and Pancreatic Cancer Risk in Five US Cohorts
... is associated with a statistically significantly increased risk of pan- creatic cancer in this large, prospective study that combined five ...and pancreatic cancer risk and also suggest an ... See full document
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The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
... control fibroblasts. The controversial role of PPARγ, showing either an autophagy-induced protumori- genic effect in the CAFs or antineoplastic effects in epithe- lial cancer cells, suggests that the ... See full document
58
LncRNA GAS5 contributes to lymphatic metastasis in colorectal cancer
... breast cancer samples relative to adjacent unaffected normal breast epithelial tissues, could controls apoptosis and down-regulated in breast cancer ...potential role of GAS5 in the human ... See full document
13
The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
... the role of the mTOR/4E-BP1 pathway in promoting chemoresistance via the autocrine and paracrine IL-6 ...crosstalk associated with ...increased cancer cell apoptosis in coculture models ...the ... See full document
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Original Article Expression of Nrf2 and NQO1 in human gastric cancer and their clinical significance
... was associated with poor overall survival in ovarian carcinoma [20] and in small cell lung cancer patients [23], ...tric cancer cells, which may reflect aggressive behavior of gastric ...mediate ... See full document
14
Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer
... important role. Hwang et al. [25] found that CM from human pancreatic stellate cells could stimulate the proliferation, migration, invasion and colony formation of pancreatic cancer cells ... See full document
5
<p>Anti-Cancer Activity of Acriflavine as Metabolic Inhibitor of OXPHOS in Pancreas Cancer Xenografts</p>
... What was found when analyzing the gene expression, both in Panc-1 cells and in the PAC006 model, was a downregulation of metabolism and in xenografts also pro- cesses related to energy production (in particular oxidative ... See full document
8
Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure
... positive cancer associated fibroblasts (CAFs) which in turn lead to an increased of an aberrant extracellular matrix (ECM) production [6, ...larly, stromal cell-derived factor-1 (CXCL12), an ... See full document
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Tumorigenic Responses of Cancer Associated Stromal Fibroblasts after Ablative Radiotherapy: A Transcriptome Profiling Study
... a role for CAFs on endo- thelial cell migration [43]. Their role in normal lung and in invasive growth and cell migration in lung cancer has been discussed ... See full document
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Cancer associated fibroblasts in hematological malignancies
... important role in promoting tumor growth and progression. If on one side tumor cells secrete a plethora of factors such as TGF-β1, PDGF, VEGF, IL-6, FGF-2, IFN-γ, TNF, MMPs involved in fibroblast activation, on ... See full document
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Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma.
... of pancreatic CAFs (pCAFassigner), demonstrating inter- and intra-tumoral heterogeneity of CAFs in human ...subtypes, associated with specific phenotypic features and prognostic ...was associated ... See full document
12
Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
... normal fibroblasts to serum [18] to the assessment of stromal TILs in the neoadjuvant setting ...extensively associated with the function of non-neoplastic cells involved in the so-called ... See full document
7
The role of cancer associated fibroblasts in esophageal cancer
... activated fibroblasts labeled with not only their specific marker α smooth muscle actin (SMA), but also beta ...esophageal cancer, which needed further ... See full document
13
A Review of Exosomes and their Role in The Tumor Microenvironment and Host-Tumor "Macroenvironment"
... Cancer-derived exosomes participate in the generation of a tumor microenvironment (TME) through paracrine signaling and in an endocrine pathway that can influence other parts of the body, referred to as a tumor ... See full document
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