[PDF] Top 20 Trabajo social, burnout y ecología emocional
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Telomerase reverse transcriptase gene amplification in hematological malignancies
... The telomerase reverse transcriptase-cleft lip and palate transmembrane protein 1-like protein (TERT-CLPTM1L) locus containing the gene encoding TERT gene is commonly exposed to som- ... See full document
11
The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... Thyroid carcinoma (TC) is an uncommon form of car- cinoma but is one of the most common malignancies in the human endocrine system [1]. It accounts for about 2% of newly diagnosed carcinoma cases and a majority of ... See full document
6
Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... Quantification of hTERTand p38 MAPK mRNA expression Total cellular RNA was extracted using a Rneasy Mini Kit (Qiagen, Valencia, CA), and cDNA was synthesized using 1 μ g of total RNA using a Transcriptor First Strand ... See full document
10
INSILICO SCREENING OF NNRTI AS POTENTIAL TARGETS FOR TUMOR CONTROL
... Protein Data Bank (PDB), is an archive for biological macromolecular crystal structures (Berman (2000)). Three dimensional structure of HIV-1 Reverse transcriptase bound with nevirapine complex was derived ... See full document
13
HTLV 1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT)
... includes the 180 bp core promoter that contains 2 E-boxes and 5 GC boxes, which represent the consensus binding sequences for Myc/Max and Sp1, respectively (Fig 4A). Interestingly, previous studies have revealed that ... See full document
11
Somatic mutations in telomerase promoter counterbalance germline loss of function mutations
... We used cell lines to test whether the promoter mutation found in cis with the WT allele is associated with increased telo- merase activity. The EBV-transformed lymphoblastoid B cell line (LCL) derived from the ... See full document
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Telomerase reverse transcriptase methylation predicts lymph node metastasis and prognosis in patients with gastric cancer
... Purpose: Telomerase activity is associated with cellular immortalization and is present in most human tumors but absent in normal ...of telomerase reverse transcriptase (TERT), a catalytic ... See full document
39
Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... protein, telomerase reverse tran- scriptase (hTERT), which stabilizes the telomeres of lin- ear chromosomes ...Although telomerase activity is present during human embryonic development, its ... See full document
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Photoactivatable RNAi for cancer gene therapy triggered by near-infrared-irradiated single-walled carbon nanotubes
... Moreover, we used the visceral index and H&E staining to determine in vivo toxicity. As shown in Figure 6B, the visceral indices of the heart, liver, spleen, lung, and kidney in each group did not differ ... See full document
12
Detection and Genotyping of Human Rotavirus VP4 and VP7 Genes by Reverse Transcriptase PCR and Reverse Hybridization
... novel reverse transcriptase PCR (RT-PCR) method for the amplification of rotavirus RNA and a reverse hybridization assay on a strip to detect amplimers and identify the specific G and P ... See full document
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RNase III Domain of KREPB9 and KREPB10 Association with Editosomes in Trypanosoma brucei
... and PF CN cell lines were excised using transient expression of Cre recombinase from undigested pLEW100Cre_del_tetO (Addgene plasmid 24019; George Cross), modified by removal of the phleomycin drug cassette, and selected ... See full document
16
Telomere elongation protects heart and lung tissue cells from fatal damage in rats exposed to severe hypoxia
... Background: The effects of acute hypoxia at high altitude on the telomere length of the cells in the heart and lung tissues remain unclear. This study aimed to investigate the change in telomere length of rat heart and ... See full document
44
A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
... and telomerase during hematopoiesis cannot be inferred simply from a single animal model but needs to be studied comparatively in several vertebrate species, as well as directly in human ...only telomerase, ... See full document
17
Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression
... Figure 6. TERT activates RNA pol III– driven promoters by directly interacting with RPC32. (A) 293T cells were trans- fected with vector, TERT, or RPC32, along with tRNA promoter–driven luciferase vectors. Forty-eight ... See full document
118
Telomerase regulates MYC driven oncogenesis independent of its reverse transcriptase activity
... of telomerase, is limiting for reconstituting telomerase activity in ...of telomerase on telomeres is not ...its reverse transcriptase activity and role in telomere ... See full document
14
Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates
... This association was found to be statistically significant for progression free p-value 0.002 and overall survival p-value 0.006 TERT promoter mutations Studies have shown that the preva[r] ... See full document
7
Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... in telomerase activity levels in ...the reverse transcriptase (RT) domain), we observed differential patterns of expression for the TERT isoforms between normoxia and hypoxia conditions (Figure ... See full document
176
Diverse regulatory manners of human telomerase reverse transcriptase
... the telomerase activity with- out hindering hTERT transcription by decreasing the full-length (FL) hTERT transcript and retaining high levels of the inactive β-deletion ...reduces telomerase activity by ... See full document
5
Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... The telomerase RNP complex plays a crucial role in maintaining telomere ...of telomerase catalytic subunit hTERT and its significance in extra- telomeric functions in modulating cellular ... See full document
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Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population
... The Chinese Han patient cohort was from Shaanxi province or nearby regions, and comprised of 302 cases and 300 controls. The characteristics of the study population are summarized in Table 1. The ages of controls and ... See full document
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