Group author details eQTLGen Consortium
M Agbessi: Ontario Institute for Cancer Research, Toronto, Canada; H Ahsan: Department of Public Health Sciences, University of Chicago, Chicago, United States; I Alves: Ontario Institute for Cancer Research, Toronto, Canada; A Andiappan: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; P Awadalla: Ontario Institute for Cancer Research, Toronto, Canada; A Battle: Department of Computer Science, Johns Hopkins University, Baltimore, United States; MJ Bonder: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; D Boomsma: Vrije Universiteit, Amsterdam, The Netherlands; M Christiansen: Cardiovascular Health Research Unit, University of Washington, Seattle, United States; A Claringbould: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; P Deelen: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; J van Dongen: Vrije Universiteit, Amsterdam, The Netherlands; T Esko: Estonian Genome Center, University of Tartu, Tartu, Estonia; M Fave´: Ontario Institute for Cancer Research, Toronto, Canada; L Franke: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; T Frayling: Exeter Medical School, University of Exeter, Exeter, United Kingdom; SA Gharib: Department of Medicine, University of Washington, Seattle, United States; G Gibson: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; G Hemani: MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; R Jansen: Vrije Universiteit, Amsterdam, The Netherlands; A Kalnapenkis: Estonian Genome Center, University of Tartu, Tartu, Estonia; S Kasela: Estonian Genome Center, University of Tartu, Tartu, Estonia; J Kettunen: University of Helsinki, Helsinki, Finland; Y Kim: Department of Computer Science, Johns Hopkins University, Baltimore, United States; H Kirsten: Institut fu¨r Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig ResearchCenter for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; P Kovacs: IFB Adiposity Diseases, Universita¨t Leipzig, Leipzig, Germany; K Krohn: Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universita¨t Leipzig, Leipzig, Germany; J Kronberg-Guzman: Estonian Genome Center, University of Tartu, Tartu, Estonia; V Kukushkina: Estonian Genome Center, University of Tartu, Tartu, Estonia; Z Kutalik: Lausanne University Hospital, Lausanne, Switzerland; M Ka¨ho¨nen: Department of Clinical Physiology and Faculty of Medicine and Life Sciences, Tampere University Hospital and University of Tampere, Tampere, Finland; B Lee: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; T Lehtima¨ki: Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; M Loeffler: Institut fu¨r Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; U Marigorta: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; A Metspalu: Estonian Genome Center, University of Tartu, Tartu, Estonia; J van Meurs: Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands; L Milani: Estonian Genome Center, University of Tartu, Tartu, Estonia; M Mu¨ller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany; M Nauck: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; M Nivard: Vrije Universiteit, Amsterdam, The Netherlands; B Penninx: Vrije Universiteit, Amsterdam, The Netherlands; M Perola: National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland; N Pervjakova: Estonian Genome Center, University of Tartu, Tartu, Estonia; B Pierce: Department of Public Health Sciences, University of Chicago, Chicago, United States; J Powell: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; H Prokisch: Institute of Human Genetics, Helmholtz Zentrum Mu¨nchen, Mu¨nchen, Germany; BM Psaty: Departments of Epidemiology, Medicine, and Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, United States; O Raitakari: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital and University of Turku, Turku, Finland; S Ring: School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; S Ripatti: University of Helsinki, Helsinki, Finland; O Rotzschke: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; S
Rue¨ger: Lausanne University Hospital, Lausanne, Switzerland; A Saha: Department of Computer Science, Johns Hopkins University, Baltimore, United States; M Scholz: Institut fu¨r Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; K Schramm: Institute of Genetic Epidemiology, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany; I Seppa¨la¨: Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; M Stumvoll: Department of Medicine, Universita¨t Leipzig, Leipzig, Germany; P Sullivan: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; A Teumer: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; J Thiery: Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; L Tong: Department of Public Health Sciences, University of Chicago, Chicago, United States; A To¨njes: Department of Medicine, Universita¨ t Leipzig, Leipzig, Germany; J Verlouw: Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands; PM Visscher: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; U Vo˜sa: Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; U Vo¨lker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; H Yaghootkar: Exeter Medical School, University of Exeter, Exeter, United Kingdom; J Yang: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; B Zeng: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; F Zhang: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; M Agbessi: Ontario Institute for Cancer Research, Toronto, Canada; H Ahsan: Department of Public Health Sciences, University of Chicago, Chicago, United States; I Alves: Ontario Institute for Cancer Research, Toronto, Canada; A Andiappan: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; P Awadalla: Ontario Institute for Cancer Research, Toronto, Canada; A Battle: Department of Computer Science, Johns Hopkins University, Baltimore, United States; MJ Bonder: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; D Boomsma: Vrije Universiteit, Amsterdam, The Netherlands; M Christiansen: Cardiovascular Health Research Unit, University of Washington, Seattle, United States; A Claringbould: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; P Deelen: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; J van Dongen: Vrije Universiteit, Amsterdam, The Netherlands; T Esko: Estonian Genome Center, University of Tartu, Tartu, Estonia; M Fave´: Ontario Institute for Cancer Research, Toronto, Canada; L Franke: Department of Genetics University, Medical Centre Groningen, Groningen, The Netherlands; T Frayling: Exeter Medical School, University of Exeter, Exeter, United Kingdom; SA Gharib: Department of Medicine, University of Washington, Seattle, United States; G Gibson: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; G Hemani: MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; R Jansen: Vrije Universiteit, Amsterdam, The Netherlands; A Kalnapenkis: Estonian Genome Center, University of Tartu, Tartu, Estonia; S Kasela: Estonian Genome Center, University of Tartu, Tartu, Estonia; J Kettunen: University of Helsinki, Helsinki, Finland; Y Kim: Department of Computer Science, Johns Hopkins University, Baltimore, United States; H Kirsten: Institut fu¨r Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig ResearchCenter for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; P Kovacs: IFB Adiposity Diseases, Universita¨t Leipzig, Leipzig, Germany; K Krohn: Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universita¨t Leipzig, Leipzig, Germany; J Kronberg-Guzman: Estonian Genome Center, University of Tartu, Tartu, Estonia; V Kukushkina: Estonian Genome Center, University of Tartu, Tartu, Estonia; Z Kutalik: Lausanne University Hospital, Lausanne, Switzerland; M Ka¨ho¨nen: Department of Clinical Physiology and Faculty of Medicine and Life Sciences, Tampere University Hospital and University of Tampere, Tampere, Finland; B Lee: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; T Lehtima¨ki: Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; M Loeffler: Institut fu¨r Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; U Marigorta: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; A Metspalu: Estonian Genome Center, University of Tartu, Tartu, Estonia; J van Meurs: Department of Internal
Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands; L Milani: Estonian Genome Center, University of Tartu, Tartu, Estonia; M Mu¨ller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany; M Nauck: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; M Nivard: Vrije Universiteit, Amsterdam, The Netherlands; B Penninx: Vrije Universiteit, Amsterdam, The Netherlands; M Perola: National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland; N Pervjakova: Estonian Genome Center, University of Tartu, Tartu, Estonia; B Pierce: Department of Public Health Sciences, University of Chicago, Chicago, United States; J Powell: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; H Prokisch: Institute of Human Genetics, Helmholtz Zentrum Mu¨nchen, Mu¨nchen, Germany; BM Psaty: Departments of Epidemiology, Medicine, and Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, United States; O Raitakari: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital and University of Turku, Turku, Finland; S Ring: School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; S Ripatti: University of Helsinki, Helsinki, Finland; O Rotzschke: Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore; S Rue¨ger: Lausanne University Hospital, Lausanne, Switzerland; A Saha: Department of Computer Science, Johns Hopkins University, Baltimore, United States; M Scholz: Institut fu¨r Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; K Schramm: Institute of Genetic Epidemiology, Helmholtz Zentrum Mu¨nchen, German Research Center for Environmental Health, Neuherberg, Germany; I Seppa¨la¨: Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; M Stumvoll: Department of Medicine, Universita¨t Leipzig, Leipzig, Germany; P Sullivan: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; A Teumer: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; J Thiery: Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universita¨t Leipzig, Leipzig, Germany; L Tong: Department of Public Health Sciences, University of Chicago, Chicago, United States; A To¨njes: Department of Medicine, Universita¨ t Leipzig, Leipzig, Germany; J Verlouw: Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands; PM Visscher: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; U Vo˜sa: Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; U Vo¨lker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; H Yaghootkar: Exeter Medical School, University of Exeter, Exeter, United Kingdom; J Yang: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; B Zeng: School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States; F Zhang: Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
Competing interests
To˜nu Esko: Reviewing Editor, eLife. The other authors declare that no competing interests exist.
Funding
Funder Grant reference number Author
Medical Research Council DTP in Precision Medicine MR/N013166/1,HGU QTL in health and disease
Paul RHJ Timmers Andrew D Bretherick David W ClarkeQTLGen ConsortiumJames F Wilson Estonian Research Compe-
tency Council
PUT 1665 Kristi Lall
Krista Fischer Wellcome Trust PhD Training Fellowship for
Clinicians
Andrew D Bretherick
Edinburgh Clinical Academic Track
204979/Z/16/Z Andrew D Bretherick
Svenska Forskningsra˚det For- mas
Svenska Forskningsra˚det For- mas
2017-02543 Xia Shen
Schweizerischer Nationalfonds zur Fo¨rderung der Wis- senschaftlichen Forschung
31003A_169929 Zolta´n Kutalik
SystemsX.ch 51RTP0_151019 Zolta´n Kutalik
AXA Research Fund Peter K Joshi
The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
Author contributions
Paul RHJ Timmers, Ninon Mounier, Formal analysis, Investigation, Visualization, Writing—original draft; Kristi Lall, Formal analysis, Investigation, Writing—original draft; Krista Fischer, Xia Shen, Con- ceptualization, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing— original draft; Zheng Ning, Xiao Feng, Formal analysis, Visualization, Writing—review and editing; Andrew D Bretherick, David W Clark, Software, Formal analysis, Writing—review and editing; To˜nu Esko, Resources, Supervision, Funding acquisition, Writing—original draft; Zolta´n Kutalik, Conceptu- alization, Resources, Software, Investigation, Methodology, Writing—original draft; James F Wilson, Conceptualization, Resources, Supervision, Funding acquisition, Writing—original draft; Peter K Joshi, Conceptualization, Supervision, Validation, Methodology, Writing—original draft, Writing— review and editing
Author ORCIDs
Paul RHJ Timmers http://orcid.org/0000-0002-5197-1267 Xia Shen http://orcid.org/0000-0003-4390-1979
To˜nu Esko http://orcid.org/0000-0003-1982-6569 James F Wilson http://orcid.org/0000-0001-5751-9178 Peter K Joshi http://orcid.org/0000-0002-6361-5059
Ethics
Human subjects: This work used existing datasets, for which ethical approval had been gathered for genetic investigation at the time of collection.
Decision letter and Author response
Decision letterhttps://doi.org/10.7554/eLife.39856.047 Author responsehttps://doi.org/10.7554/eLife.39856.048