20.201 DM Prob Set # 2

20.201 DM Prob Set # 2

October 2013

1

Identify the likely sites for aliphatic hydroxylation by P450

S Tolbutamide

NH O

O

H

C C NH CH

CH

CH

CH

O

OH

Testosterone

N O S

NH O

Pioglitazone O

O

(use asterisks to identify sites)

2

Pindolol

1.Show products that lead to formaldehyde 2. Show products that lead to isopropylamine

3

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20.201 Mechanisms of Drug Actions

Fall 2013

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