• No se han encontrado resultados

20.201 Drug Metabolism Problem Set 1

N/A
N/A
Info
Descargar
Protected

Academic year: 2023

Share "20.201 Drug Metabolism Problem Set 1 "

Copied!
3
0
0

Cargando.... (Ver texto completo ahora)

Descargar ahora ( 3 página )

Texto completo

(1)

20.201 Drug Metabolism Problem Set 1

O Hydrolysis

1.

O

2.

O Oxidation

NH2

O

3.

GST/GSH

NH2

NH2

4.

N N Reduction

NH2 S O H2N

Oxidation

5.

N

Oxidation

6.

O

Oxidation

7.

N N O

Oxidation O

8.

N H

1

(2)

Hypoperamericillin

O F

HO F

N

HO N

S H N

OH O

There are 3 sites in this molecule that can be activated to electrophilic intemediates. Each electrophile in turncanbedeactivatedbymorethanonePhase2enzyme.Identifythesitesanddrawthestructuresof

the electrophiles. Then identify the Phase 2 enzmes for each detoxication reaction, and draw the final detoxified products.

2

(3)

MIT OpenCourseWare http://ocw.mit.edu

20.201 Mechanisms of Drug Actions

Fall 2013

For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.

Referencias

Descargar ahora ( PDF - 3 página - 511.34 KB )

Documento similar

7.344 Directed Evolution:

MIT OpenCourseWare http://ocw.mit.edu 7.344 Directed Evolution: Engineering Biocatalysts Spring 2008 For information about citing these materials or our Terms of Use, visit:

PCR mutagenesis

MIT OpenCourseWare http://ocw.mit.edu 7.344 Directed Evolution: Engineering Biocatalysts Spring 2008 For information about citing these materials or our Terms of Use, visit:

Evolution of an aspartate aminotransferase

MIT OpenCourseWare http://ocw.mit.edu 7.344 Directed Evolution: Engineering Biocatalysts Spring 2008 For information about citing these materials or our Terms of Use, visit:

In vitro compartmentalization

MIT OpenCourseWare http://ocw.mit.edu 7.344 Directed Evolution: Engineering Biocatalysts Spring 2008 For information about citing these materials or our Terms of Use, visit:

First, explain what the 'picture-in-the-head' theory is supposed to be

MIT OpenCourseWare http://ocw.mit.edu 24.08J / 9.48J Philosophical Issues in Brain Science Spring 2009 For information about citing these materials or our Terms of Use, visit:

5.04 Principles of Inorganic Chemistry II ��

MIT OpenCourseWare http://ocw.mit.edu 5.04 Principles of Inorganic Chemistry II �� Fall 2008 For information about citing these materials or our Terms of Use, visit:

5.04 Principles of Inorganic Chemistry II ��

MIT OpenCourseWare http://ocw.mit.edu 5.04 Principles of Inorganic Chemistry II �� Fall 2008 For information about citing these materials or our Terms of Use, visit:

5.04 Principles of Inorganic Chemistry II ��

MIT OpenCourseWare http://ocw.mit.edu 5.04 Principles of Inorganic Chemistry II �� Fall 2008 For information about citing these materials or our Terms of Use, visit: