[PDF] Top 20 Big Data: desarrollo, avance y aplicación en las Organizaciones de la era de la Información
Has 10000 "Big Data: desarrollo, avance y aplicación en las Organizaciones de la era de la Información" found on our website. Below are the top 20 most common "Big Data: desarrollo, avance y aplicación en las Organizaciones de la era de la Información".
Plasma tau in Alzheimer disease
... were age $60 years, MMSE score of 28 to 30, and fluent in Swedish. Exclusion criteria were the presence of subjective cognitive impairment, significant neurologic or psychiatric disease, dementia, or MCI. Patients ... See full document
6
Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation
... Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer’s. Several studies have indicated that restricted sleep ... See full document
140
Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
... human tau, ...full tau pathology with prominent tau aggregation and cognitive deterioration as described earlier [28], whereas the anti-aggregant mice have no tau aggregates and corresponding ... See full document
21
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
... Aβ42, tau, and ptau are important biomarkers for Alzheimer’s disease ...and tau change before clin- ical symptoms of AD are ...the disease progresses, and tau levels ...and tau ... See full document
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Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study
... comprised of phosphorylated microtubule associated protein tau (p-MAPT). Evidence suggests that both neuritic plaques (a subset of extracellular Aβ plaques demonstrating argyrophillic, p-MAPT-immunoreactive ... See full document
54
A novel Alzheimer disease locus located near the gene encoding tau protein
... Based on the observation that overexpression of human ApoE4 in transgenic mouse neurons results in hyperphosphorylation of tau, 37 it is possible that associations with AD-related loci in the chromosome 17q21.31 ... See full document
22
First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model
... same tau molecule or whether distinct subspecies of pathological tau display a variety of different phospho- ...of tau should attack a common denominator of the diseased tau proteome—the ... See full document
144
Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
... human disease [101], the gener- ation of genetically modified mice expressing mutations in genes that cause AD has enabled progress in under- standing its ...(a tau mutation causing frontotemporal de- ... See full document
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Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
... In summary, our results suggest that CSF HFABP re- flects intra-cranial lipid biology and associates with Aβ- associated neurodegeneration irrespective of tau. Clinic- ally, our findings suggest that HFABP may ... See full document
298
Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
... that tau PET is a more sensitive marker for detecting the earliest cognitive changes in AD than Aβ PET and cortical thickness ...gional tau PET and cortical thickness measures showed strong cognitive ... See full document
6
Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β
... (4R tau/Alexa 488 and RD3/Alexa 568) were captured by VS120 on motorized stage with 10 times objective lens in separate fluorescence channels, and put together to make a seamless broad image, covering the whole ... See full document
14
Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?
... Alzheimer’s Disease Cooperative Study-Activities of Daily Living ...in plasma A β -42 levels, but not A β -40 levels, were observed in patients treated with intravenous ...and plasma but no effect ... See full document
6
Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia
... of Tau from microtubules as a result of Tau phosphorylation could further promote the destabilization of microtubules, either by lack of stabilization and/or by loss of protection against ...severing. ... See full document
5
Caspase cleavage of tau is an early event in Alzheimer disease tangle pathology
... monitoring tau filamentous aggregates (38). Tau was incubated in the presence of heparin, which accelerates tau aggregation in vitro, so that we could assay filament formation in real time ... See full document
142
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX-
... neuronal tau as neurofibrillary tangles in the human brain is a hallmark of Alzheimer disease ...and tau- positive ...4-repeat tau as pretangles in neurons, and as coiled body-like ... See full document
33
Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome
... AD: Alzheimer ’ s disease;; ADNI: Alzheimer ’ s Disease Neuroimaging Initiative; AUC: area under the curve; BL: baseline; CSF: cerebrospinal fluid; CV: coefficient of variation; DS: Down ... See full document
9
Odor identification as a biomarker of preclinical AD in older adults at risk
... M.-E. Lafaille-Magnan has received research support from the Lazlo & Etelka Kollar fellowship fund. M.-E. Lafaille-Magnan is the Brain Reach High School program coordinator, for which she has received an award from ... See full document
17
Advances with RNA interference in Alzheimer’s disease research
... both tau hyperphosphorylation, which reduces the binding of tau to microtubules, and the sequestration of hyperphosphorylated tau into neurofibrillary tangles (NFTs), which reduces the amount of ... See full document
22
Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
... CSF tau and PET tau measures correlate, 6,10 but those results stem from populations mainly consisting of controls, including few cases with AD ...PET tau measures have similar or different di- ... See full document
30
Current radiotracers to image neurodegenerative diseases
... repeat tau isoform; 4R: Four repeat tau isoform; AChE: Acetylcholine esterase; AD: Alzheimer ’ s disease; A β : β - amyloid; bvFTD: Behavioural variant of frontotemporal dementia; CBD: ... See full document
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