[PDF] Top 20 Comparando modelos alternativos de precificação de ativos : uma análise do mercado brasileiro
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Design, Synthesis and Evaluation of Diphenyl ether Derivatives as Antitubercular and Antibacterial Agents
... the antitubercular drugs, the hepatotoxicity of the synthesised compounds was also evaluated by MTT assay using HepG2 ...300µg/mL. Antibacterial activity study was carried out by agar well diffusion ...no ... See full document
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Synthesis and biological evaluation of amino alcohol derivatives of 2 methylbenzimidazole as antitubercular and antibacterial agents
... Infectious microbial disease remains a pressing problem worldwide, because microbes have resisted prophylaxis or therapy longer than any other form of life. In recent decades, the prevalence of drug resistant bacteria is ... See full document
19
Design, Synthesis, Characterization and Biological Evaluation of Some Novel Isatin Derivatives as Antitubercular Agents.
... drug design have changed over time, exploiting and driving new technological advances to solve the varied bottlenecks found along the ...chemical synthesis of drug-like molecules, the emergence of ... See full document
8
Design, Synthesis, Characterization and Biological Evaluation of Some Novel Butyrolactone Derivatives of Chalcone as Antitubercular Agents.
... The process of drug discovery is very complex and requires an interdisciplinary effort to design effective and commercially feasible drugs. The current scenario of development of new drugs needs no emphasis in ... See full document
259
Design, Synthesis, Characterization and Biological Evaluation of Some Novel Antitubercular Agents.
... to design better ligands can profit from a better understanding of the degree to which known ligands are ,or fail to be ,complementary to the receptor as well as from a critical assessment of the degree to which ... See full document
2
Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents
... mimic diphenyl ether derivatives have been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis ...possess antitubercular activity ... See full document
7
Design and Synthesis of New Bioactive 1,2,4-Triazoles, Potential Antitubercular and Antimicrobial Agents
... 1,2,4-triazole derivatives were synthesized using appropriate synthetic route and structures were confirmed by infrared spectroscopy, proton nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, mass ... See full document
7
Synthesis, antimicrobial and cytotoxic activity of new heterocyclic hybrids based on 2,5-dimethylpyrrole and pyrrole scaffolds
... the synthesis of novel pyrrole derivatives and in vitro evaluation of antimicrobial (antibacterial and antifungal) and antitubercular activity against Mycobacterium tuberculosis H 37 Rv ... See full document
11
Novel pyrazolinyl thiocarboxamide derivatives: Design, synthesis and biological evaluation as antibacterial, antifungal and cytotoxic agents
... A mixture of 1, 5-bis (4-methylphenyl)-penta-1, 4-dien-3- one (600mg, 2.2mmol) and thiosemicarbazide (625mg, 6.87mmol) were dissolved in ethanol, 0.2 ml acetic acid was added and refluxed with stirring 10 h, while ... See full document
13
Design, Synthesis and Antiinflammatory Evaluation of 5(6)-(un)-substituted-1H-Benzimidazol-2-ylthioacetylpiperazine Derivatives
... synthesized derivatives with these amino acids were not ...synthesized derivatives with substitution of oxygen in heterocyclic ring and sulfonyl group attached to the aromatic ring, or to the amino group ... See full document
7
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PYRIMIDINE DERIVATIVES
... the synthesis of such compounds is of great interest in synthetic organic chemistry [1] ...pyrimidine derivatives occupy an important place in the present day therapeutics [2] ...their derivatives ... See full document
125
Synthesis and pharmacological evaluation of newer substituted 2-oxo/thiobarbiturinylbenzoxa/thiazepine derivatives as potent anticonvulsant agents.
... petroleum ether (40-60°C) and recrystallised from methanol/water to give compound 2a (90%), mp 240°C; IR (KBr) 3320 (NH), 1620 (CH=CH), 1730, 1720, 1715, 1680 (amidic (C=O),1580 (C…C of aromatic ring), 710 (C-Cl) ... See full document
5
Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity
... (Gram negative) and Candida albicans and Aspergillus niger by tube dilution method. MIC (mg/ml) was the concurrent reading obtained from the experiment which was done thrice and is given in Table 2. ... See full document
6
SYNTHESIS AND BIOLOGICAL EVALUATION OF SUBSTITUTED DIPHENYL IMIDAZOLE DERIVATIVES
... 1. The antibacterial activity was carried using agar plate technique. Ofloxacin was taken as the reference drug. Nutrient agar medium was sterilized in an autoclave at 121 0 C (15lbs/sq.in) for 20 minutes. It was ... See full document
15
Synthesis of Fluoroquinolones Derivatives as Antimicrobial Agents
... Fluoroquinolones are well known to have an anti-infective action. In the present study we have described the synthesis of novel florouquinolones derivative as antimicrobial agent. The biological test highlighted a ... See full document
19
Synthesis of New Chalcone Derivatives as Antibacterial Agents
... The increase in antibiotic resistance due to multiple factors has encouraged the search for new compounds which are active against multidrug-resistant pathogens. In a wide search program towards new and efficient ... See full document
52
SYNTHESIS AND PRELIMINARY EVALUATION OF NOVEL 1, 5-BENZOTHIAZEPINE DERIVATIVES AS ANTI-LUNG CANCER AGENTS
... 5-benzothiazepine derivatives having a biologically active thiazepine moiety was synthesized by the condensation of substituted chalcones with 2-aminothiophenol using conventional as well as non-conventional ... See full document
319
Synthesis and evaluation of antitubercular activity of some thiobenzimidazolyl derivatives
... thiobenzimidazole derivatives, a series of alkyl sulphonyl benzimidazole was prepared by oxidation of substituted sulphanyl benzimidazole, also a set of benzimidazoles bearing indole-2, 3-dione substituents was ... See full document
71
INSILICO DESIGN AND MOLECULAR DOCKING STUDIES OF NOVEL 1, 2, 4- TRIAZOLE DERIVATIVES AS CYP-51 INHIBITORS
... 7. Rohini Diwedi, Alexander S, Chandrasekar MJN. Rapid and efficient synthesis of microwave assisted synthesis of some bis-1,2,4-triazole derivatives and their antioxidant and anti-inflammatory ... See full document
6
Synthesis and Evaluation of 2 Amino 4H Pyran 3 Carbonitrile Derivatives as Antitubercular Agents
... 2.2. Evaluation of Antitubercular Activity The antitubercular activity of racemic 2-amino-4H-pyran- 3-carbonitriles 2a-2e, homochiral 2-amino-4H-pyran-3- carbonitriles (S)-2a, (S)-2d, (R)-2a, and ... See full document
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