[PDF] Top 20 Concurrencia de culpas en la responsabilidad patrimonial de la Administración Pública
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Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease
... The inclusion criteria for HNC in the present study were as follows: (1) the absence of memory complaints, (2) normal general cognition (within 1 standard devi- ation (SD) of the age- and education-adjusted norms of the ... See full document
11
HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease
... the amyloid hypothesis in Alzheimer ’ s disease (AD) first elaborated in 1991, has yet to provide positive outcomes notwithstanding the billions spent on clinical trials ...extracellular ... See full document
7
The “rights” of precision drug development for Alzheimer’s disease
... dysfunction, neurodegeneration, ...positive amyloid PET and low levels of tau as shown by tau PET, fMRI measures of the default mode network (DMN) reveal hyperactive circuit ...elevated amyloid and ... See full document
20
FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study
... to neurodegeneration and was labeled as “N” biomarkers as the research framework ...precise, blood-brain barrier (BBB) transport, abnormality ...Alzheimer’s Disease Neuroimaging Initiative (ADNI) ... See full document
31
Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies
... In the context of this study, we also sought to deter- mine whether enrichment strategies could improve the sensitivity to change over time of these ADAS-Cog vari- ants. Since the introduction of enrichment as part of ... See full document
55
Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease
... Even though a link between microglial activation and synaptic degeneration can be postulated, we found no correlation between neurogranin and YKL-40 in our study. As detailed above, YKL-40 is a rather unspecific marker ... See full document
8
The overlap between vascular disease and Alzheimer’s disease - lessons from pathology
... harbor neurodegeneration without Aβ burden, but as- sociation of neurodegenerative lesions with CVD can emerge through non-Aβ pathways within regions most affected by AD ... See full document
18
IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology
... the blood of AD patients compared to controls ...brain amyloid pathology and found no significant reduction of either Aβ40 or Aβ42 in both soluble and insoluble protein frac- tions from treated mice, ... See full document
99
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
... levels. Blood samples were collected by cardiac puncture, processed to plasma, frozen on dry ice and stored at -80°C until determination of compound levels by ... See full document
400
Apolipoprotein E ε4 Does Not Modulate Amyloid β–Associated Neurodegeneration in Preclinical Alzheimer Disease
... the Alzheimer Disease Neuroimaging Initia- tive (ADNI) (National Institutes of Health Grant U01 ...Janssen Alzheimer Immunotherapy Research & Development LLC, Johnson & Johnson Pharmaceutical ... See full document
91
Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 ... See full document
5
Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
... of Alzheimer ’ s disease ...of amyloid beta (A β ) plaques and ...A β in the cerebral vasculature is closely associated with cognitive decline, and disruption of the ... See full document
98
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... to β-amyloid (Aβ) protein in the blood vessel walls [5] and likely responsive to corticosteroid or other immunosuppres- sive agents ...9]. Amyloid-related imaging abnormalities (ARIA) ... See full document
9
Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report
... AD: Alzheimer ’ s disease; ADMA: Asymmetric dimethylarginine; A β 40: Beta- amyloid peptide with 40 amino acids; A β 42: Beta-amyloid peptide with 42 amino acids; BBB: ... See full document
6
Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease
... A β deposits shows that the differences between AD and controls are not only quantitative, but also related to the specific compartments of brain parenchyma and vascula- ture where IsoD-A β and pE3-A ... See full document
46
Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice
... of Alzheimer ’ s disease (AD), including altered CV ...prevents amyloid-beta (A β )-induced damage to brain endothelial cells in ...A β levels using an AD-Tg model that ... See full document
40
Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
... circulating amyloid-aggregation-prone factors were produced by regional changes of CBF or that regional manipulation of CBF results in global im- pairment of Aβ clearance and thus increased overall amyloid ... See full document
6
Post-mortem assessment in vascular dementia: advances and aspirations
... It is widely accepted that, by analogy with spontan- eous intracerebral haemorrhage, the pathological pro- cesses underlying microbleeds differ according to their location in the brain, with CAA being the most notable ... See full document
21
18F-florbetaben Aβ imaging in mild cognitive impairment
... is associated with altered activity patterns in the default network during memory encoding tasks [46], WMH are associated with a faster decline in global cognitive performance, executive function and ... See full document
114
Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
... AD: Alzheimer ’ s disease; ADNC: AD neuropathologic change; ADNI: Alzheimer ’ s Disease Neuroimaging Initiative; ALFA: Alzheimer and Families; AUC: Area under the curve; A ... See full document
6
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