[PDF] Top 20 Derecho del trabajo y defensa de la competencia.
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High PD-L1 Expression Is Closely Associated With Tumor-Infiltrating Lymphocytes and Leads to Good Clinical Outcomes in Chinese Triple Negative Breast Cancer Patients
... of PD-L1 to a poor outcome have been shown in a number of researches on mixed ...The PD-L1 expression was assessed as an index of adverse prognostic factor for other pernicious cancers, ... See full document
6
High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
... between tumor growth and host surveillance, finally promoting tumor ...metastasis. PD-1/PD-L1 checkpoint antibodies help to reconstruct the balance between the host and tumor, ... See full document
72
PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer
... of PD-1/PD-L1 expression status demonstrated that the expression of PD-1 was associ- ated favorable survival of breast cancer patients while ... See full document
16
Should Tumor Infiltrating Lymphocyes, Androgen Receptor, and FOXA1 expression predict Clinical Outcome in Triple Negative Breast Cancer Patients?
... the tumor aggressiveness is also highlighted by the correlation between AR and cNHERF1, a marker of tumor progression in BCs [25,38], and involved in different signaling pathway ...more ... See full document
10
<p>Expression of PD-1 and PD-L1 on Tumor-Infiltrating Lymphocytes Predicts Prognosis in Patients with Small-Cell Lung Cancer</p>
... higher expression levels of CD3, CD4, CD8, and FOXP3 were associated with better survival, suggesting that TILs could increase anti- tumor ef fi ...22 High expression of CD3 has been ... See full document
23
Clinical significance of tumor-infiltrating lymphocytes in breast cancer
... Tumor infiltrating lymphocytes (TIL) play an essential role in mediating response to chemotherapy and improving clinical outcomes in all subtypes of breast ...cancer. ... See full document
6
Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer
... for cancer therapy, is CTLA-4 [16, ...ecule closely related to CD28) results in inhibition of im- mune responses, and exhausted T cells, which are less able to proliferate or to secrete T helper 1 (Th1) ... See full document
50
PD-L1 and PD-1 expression are correlated with distinctive clinicopathological features in papillary thyroid carcinoma
... The background disease was classified as CLT and non-CLT in the present study. According to Mizukami’s definition, CLT was divided into four groups: chronic thyroiditis, oxyphilic; chronic thyroiditis, mixed; chronic ... See full document
6
Programmed death-ligand 1 expression in gastric adenocarcinoma is a poor prognostic factor in a high CD8+ tumor infiltrating lymphocytes group
... Tissue microarray (TMA) blocks were constructed using tissue cores with 0. 2-mm diameters punched from the representative tumor area of the donor block. The TMA blocks were paired with normal-tissue controls. ... See full document
135
34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 2
... TCGA-AML patients into two distinct clusters expressing genes associated with adaptive immune re- sponses and an interferon (IFN)-gamma-dominant tumor microenvir- onment (TME) and gene modules ... See full document
8
The clinical promise of immunotherapy in triple-negative breast cancer
... targeting PD-1 or PD-L1 have become a focus of moving immune- checkpoint blockade into many ...lung cancer, Hodgkin’s lymphoma, bladder cancer, gastroesophageal cancer, primary ... See full document
154
The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
... For immunofluorescence, sections were thawed and dried at room temperature and rinsed in PBS. For fix- ation, cells were washed with PBS and followed by 4% PFA for 5 min. Samples were permeabilized with 0.25% Triton ... See full document
883
Effect of neoadjuvant chemotherapy on tumor infiltrating lymphocytes and PD L1 expression in breast cancer and its clinical significance
... and PD-L1 expression also correlated; stromal TILs were sig- nificantly higher in the PD-L1-positive cases (p = ...analysis, PD-L1 positivity was sig- nificantly higher in ... See full document
9
Small breast epithelial mucin tumor tissue expression is associated with increased risk of recurrence and death in triple-negative breast cancer patients
... Normal breast tissues were in general weakly or ...relevant clinical cut-off point and the standard evaluation methods reported for SBEM in the ...of tumor cells staining with/without weakly stained ... See full document
5
Research Paper Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer In Ah Park , Sun-Hee Heo , In Hye Song , Young-Ae Kim , Hye Seon Park
... a high cytoplasmic expression of HMGs is significantly positively correlated with larger amounts of TILs in TNBC ...Cytoplasmic expression of the ERS molecules XBP-1 and p-eIF2a was also found to be ... See full document
8
Original Article Tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) in pretherapeutic breast cancer core biopsies: Anti-tumoral effect of immune cells associated with neoadjuvant chemotherapy
... addition, high TIL score of PNB was correlated with smaller post-NAC tumor size, lower post-NAC pathologic T stage and higher pCR ...eliminate cancer cells and are a predictor of response to NAC ... See full document
24
Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma
... the clinical data of the 13 patients and measured the expression of programmed death-ligand 1 (PD-L1) in tumors using immunohistochemical ...eight patients with LELCC were ... See full document
151
PD-L1 expression on stromal tumor-infiltrating lymphocytes is a favorable prognostic factor in ovarian serous carcinoma
... 270 patients with primary epithelial ovarian cancer who underwent explorative laparotomy at the Department of Gynecology of Pusan National University Hospital from 1998 to 2013 were included in the ...All ... See full document
7
Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers
... gene expression occurs less frequent in genomic stable (GS) and chromosomal instable (CIN) GCs, we also noted the presence of PD-L1 expression in inflammatory cells in a significant minority ... See full document
8
The frequency of high PD-L1 expression is low in lung adenocarcinoma patients from Northeast Brazil
... of PD-L1 expression (TPS ≥50%) in the present study compared to published data in the literature is likely related to distinct methods and anti- bodies ...different PD-L1 IHC assays ... See full document
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