[PDF] Top 20 Derecho y políticas ambientales en Navarra
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Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers
... tumor cell intrinsic and extrinsic mecha- ...for cell proliferation and apoptosis ...by small molecule inhibitors led to the transcriptional activation of p53, which in turn activates the expression ... See full document
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Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications
... guide therapeutic strategies, accumulation of large volume sequencing data from a specific tumor type would also enable discovery of novel oncogenic mutations that have not been well-described in the tested tumor ... See full document
5
CXCR4/CXCL12 Axis in Non Small Cell Lung Cancer (NSCLC) Pathologic Roles and Therapeutic Potential
... of lung cancer is based on the TNM clas- sification system ...Pathologically lung cancer is classified into non-small cell lung cancer (NSCLC) accounting for 80% of cases, and ... See full document
7
Potential Oncogenic Role of the Papillary Renal Cell Carcinoma Gene in Non Small Cell Lung Cancers
... Three different PRCC-specific siRNAs (siPRCC-1, siPRCC-2, and siPRCC-3) were purchased from Invitrogen (Carlsbad, CA). Their sequences were as follows: siPRCC-1, UUG AUU UCU UCU CUC CCU CGG UUC CGGA ACC GAG GGA ... See full document
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<p>Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade</p>
... stem cell factor receptor (c-Kit), has been developed independently in ...tumor cell growth, proliferation, angiogenesis, and metastasis in several human cancers, including ... See full document
19
A meta-analysis for CXCR4 as a prognostic marker and potential drug target in non-small cell lung cancer
... tissues; 2) researches revealing the relationship between CXCR4 expression and NSCLC clinicopathological parameters and prognosis; and 3) studies providing sufficient information to estimate hazard ratio (HR) ... See full document
8
Epithelial cell migration as a potential therapeutic target in early lung cancer
... Rho-GTPase-dependent cell migration (figure ...addition, human melanocytes with mutated TP53 demonstrated an almost five-fold increase in GTP-bound RhoA activity, coupled with increased migratory capacity ... See full document
171
Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer
... tissue and its near absence from circulating lymphocytes, combined with its presence in 16% of NSCLC patient biopsies suggest a significant therapeutic window for CD70 targeted therapy. Moreover, we have ... See full document
81
Integrated molecular portrait of non-small cell lung cancers
... Human lung cancers are classified into two major sub- types, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), with the latter ... See full document
9
Therapeutic vaccines in non-small cell lung cancer
... breast, lung, colon, pancreatic, and ovarian cancers that is believed to be involved in tumor cell migration and resistance to chemotherapy-related ...attractive target for immune ... See full document
5
HSP90 as a novel molecular target in non-small-cell lung cancer
... Table 2. These compounds have demonstrated significant potential in NSCLC in both preclinical and human ...to target multiple oncogenes at the same time. The GALAXY-2 study ... See full document
12
Original Article Diagnostic significance of circulating let-7c-5p and its potential target gene network in non-small cell lung cancers
... NSCLC cell proliferation by inducing G1 arrest and suppress tumorigene- ...This cell growth inhibitory function was achieved via targeting different genes, such as HOXA1 [33], ITGB3, MAP4K3 [21], ABCC2, ... See full document
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The epidermal growth factor (EGFR) in non small cell lung cancer (NSCLC) : biomarker and therapeutic target
... main potential drawback o f CISH compared with FISH is that most CISH studies have been performed on frozen sections, and only a single colour can be developed per section, meaning that one is not able to evaluate ... See full document
21
Epiregulin as a therapeutic target in non-small-cell lung cancer
... various human cancers and has been implicated in tumor progres- sion and ...expression. Non-small-cell lung cancers (NSCLCs) harboring KRAS, BRAF, or EGFR mutations ... See full document
7
Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity
... Abstract: Worldwide prevalence of obesity has nearly doubled since 1980. Obesity is the result of interactions among the environmental factors, genetic predisposition, and human behavior. Even modest weight ... See full document
6
Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model
... 5-year relative survival of 18% [3]. Depending on the stage of cancer, treatment options for people with NSCLC include surgical resection, chemotherapy, radia- tion therapy, targeted therapy and immunotherapy [4, 5]. ... See full document
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Original Article MicroRNA-140 inhibits tumor progression in nasopharyngeal carcinoma by targeting CXCR4
... We performed apoptosis assay to determine the effects of miR-140 on apoptosis of CNE-1 and HONE-1 cells. Briefly, after 48 h of transfec- tion with lentivirus, the cells were harvested, washed with phosphate-buffered ... See full document
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Multiparametric profiling of non–small-cell lung cancers reveals distinct immunophenotypes
... B cell infiltrate and also B cells from matched normal lung and generated RNA sequencing (RNAseq) data with single-cell resolution (29, ...normal lung, 83 from tumor) passed our quality ... See full document
5
<p>The Clinical Diagnostic and Prognostic Value of Dickkopf-1 in Cancer</p>
... with non-small cell lung cancer through Western blotting, and detected DKK1 autoantibodies in the serum by indirect ...of non-small cell lung ...in ... See full document
25
Outcome and prognostic factors of multimodal therapy for pulmonary large-cell neuroendocrine carcinomas
... consensus on whether LCNEC should be treated accord- ing to SCLC or NSCLC protocols [13]. Among others, Sun et al. claimed that LCNEC should receive treatment similar to SCLC, while Varlotto et al. insisted on treat- ing ... See full document
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