[PDF] Top 20 El compromiso de China con el desarrollo del Tercer Mundo : caso Angola
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Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
... of nintedanib on ECM metabolism. We found that nintedanib induced the activity and protein levels of MMP-2, and reduced the levels of ...duced lung fibrosis in mice was primarily due to TIMP ... See full document
513
Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls
... isolated from IPF patients show particular properties such as insufficient autophagy [9, ...affects fibrosis [12]. Autophagy inhibition in lung fibroblasts induced protea- somal ... See full document
23
Impact of novel antifibrotic therapy on patient outcomes in idiopathic pulmonary fibrosis: patient selection and perspectives
... Abstract: Patients with idiopathic pulmonary fibrosis, an incurable, progressive fibrotic interstitial lung disease, suffer an impaired quality of life due to symptoms, resultant ... See full document
6
Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib
... Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with no clear etiology and a paucity of therapeutic ...options. Nintedanib ... See full document
7
Progression of fibrosing interstitial lung disease
... and nintedanib are antifibrotic medications indicated for the treatment of IPF based on high-quality randomized placebo-controlled trials [18, 19, 48, ...of fibroblasts, which are key cells in the ... See full document
9
Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity
... the effects of nintedanib on the fibrocyte-induced proliferation of lung ...by nintedanib mainly at a con- centration of 100 nM or more ...of fibroblasts, whereas VEGF-A did not ... See full document
8
A high content, phenotypic ‘scar-in-a-jar’ assay for rapid quantification of collagen fibrillogenesis using disease-derived pulmonary fibroblasts
... as pulmonary fibrosis, chronic kidney disease (CKD) and non-alcoholic steato- hepatitis (NASH) [1, ...the lung, idiopathic pulmon- ary fibrosis (IPF) presents as a chronic, progressive ... See full document
8
Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
... bleomycin-induced fibrosis in rodents resembles rather poorly the IPF in humans [16, 17], and further, the pulmonary anatomy and cellular components of ro- dents and other experimental animals are very ... See full document
204
Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis
... among patients with SSc-ILD in clinical trials [60, ...data from retrospective studies or case series as well as expert opinion, and drugs are often used off-label [62, ...that patients randomised to ... See full document
13
The world is not enough – the value of increasing registry data in idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is a rare, progressive interstitial lung disease (ILD) with a poor prognosis ...of anti-fibrotic medication on slowing down lung ... See full document
32
Original Article Dihydroartemisinin supresses inflammation and fibrosis in bleomycine-induced pulmonary fibrosis in rats
... of pulmonary fibrosis by dihydroartemisinin maybe at least partially attributed to its inhibi- tory effect on fibrogenic cytokine production, which thereby modulates collagen ...experimental lung ... See full document
425
Temporal echocardiographic assessment of pulmonary hypertension in idiopathic pulmonary fibrosis patients treated with nintedanib with or without oxygen therapy
... Among patients in the IPF cohort of the Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, between November 2015 and September 2017, IPF patients who started ... See full document
38
1 Acute exacerbation of Idiopathic Pulmonary Fibrosis 2
... Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis.. Bräunlich J, Beyer D, Mai D, et al[r] ... See full document
5
Efficacy and safety of nintedanib in advanced idiopathic pulmonary fibrosis
... of patients was relatively small and patients in the ad- vanced group were more frequently excluded from the efficacy analysis than those in the non-advanced ...remaining patients might be ... See full document
11
Obstacles to early treatment of idiopathic pulmonary fibrosis: current perspectives
... positive effects on end points of FVC% decline, 6-minute walk distance, and dyspnea scores, when compared with ...baseline lung function, experienced disease progression at 12 months, though pirfenidone ... See full document
6
C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
... RNA from lung and other tissues was homoge- nized in guanidium-phenol-chloroform and isolated by using an RNeasy mini kit (Qiagen, Hilden, ...RNA from cells in vitro was isolated by using a ... See full document
9
Lung transplantation in chronic obstructive pulmonary disease: patient selection and special considerations
... which patients with COPD will benefit most from lung transplant and at what point in the course of the disease listing should ...which lung transplant is performed, COPD has a slower rate of ... See full document
15
Safety, tolerability and appropriate use of nintedanib in idiopathic pulmonary fibrosis
... for patients with intermittent diarrhea over a prolonged period, some investigators may have reported this as sev- eral events and others as a single event, reducing the precision of our estimate of the number and ... See full document
9
Anti glomerular basement membrane glomerulonephritis following nintedanib for idiopathic pulmonary fibrosis: a case report
... Despite nintedanib being increasingly used to treat pa- tients with IPF, this is the first reported case of an asso- ciation with ...because anti-GBM disease is not only a rare disease but also the ... See full document
14
Review Article IPF and lung cancer: homologous but different endings, the progress in the correlation research
... that idiopathic pulmonary fibrosis is inclined to combine with lung cancer in recent ...of lung cancer in pulmonary fibrosis patients among doctors and ...of ... See full document
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