[PDF] Top 20 Estudio sistemático de una población de pacientes con hipertensión pulmonar
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Frequency of BCR-ABL Fusion Transcripts in Iranian Azeri Turkish patients with Chronic Myeloid Leukemia
... of BCR-ABL fusion transcripts in our ...of transcripts (b3a2 and b2a2) was found in ...the frequency of b3a2 and b2a2 transcripts in 75 Iranian patients with ... See full document
9
Frequency of Bcr Abl Fusion Oncogene Splice Variants Associated with Chronic Myeloid Leukemia (CML)
... the frequency of b3a2 and b2a2 was found to be ...the patients. Spleen was grossly enlarged in most of the patients and mildly enlarged in some but without any correlation to transcript ...the ... See full document
112
Molecular measurement of BCR-ABL transcript variations in chronic myeloid leukemia patients in cytogenetic remission
... the myeloid compart- ment, but the cells still retain the capacity to differenti- ate and function ...the myeloid compartment undergoes transformation, with an increased number of immature myeloid ... See full document
6
Targeted therapy: resistance and re-sensitization
... Inhibitors of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) EGFR represents a member of the cell surface receptor tyrosine kinase (RTK) molecular family, and it is activated upon ligand ... See full document
131
Clinical proteomics of myeloid leukemia
... of leukemia The identification of proteins in cancer is predominantly performed by mass spectrometry (MS) analysis of fractionated proteins, or indirectly through probing with wellcharacterized ...in ... See full document
5
Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
... CML-specific BCR-ABL ...the BCR-ABL fusion protein and can process and present peptides derived from the BCR-ABL junction on the cell surface in association with HLA class ... See full document
8
Effects of Purvalanol A on Imatinib-Sensitive and -Insensitive Chronic Myeloid Leukaemia Cell Lines
... However, the emergence of tyrosine kinase inhibitors (TKIs) totally changed the landscape for the treatment of CML. Imatinib mesylate (Gleevec, STI-571) was developed as a small molecule inhibitor of ABL kinase ... See full document
12
Molecular signatures of chronic myeloid leukemia stem cells
... Mouse BCR-ABL-expressing stem/progenitor cells ex- press a higher level of CD44, which contributes func- tional E-selectin ligands ...CML, BCR-ABL-transduced progenitors from CD44-mutant ... See full document
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BCR-ABL1 transcript types showed distinct laboratory characteristics in patients with chronic myeloid leukemia.
... the BCR and ABL genes have been described, more than 95% of patients with chronic myeloid leukemia (CML) produce an mRNA in which either the BCR exon 13 (e13) or ... See full document
270
A stochastic model of oncogene expression and the relevance of this model to cancer therapy
... We consider the cellular phenotypic entropy to remain constant during therapies that are observed to be reversi- ble. As an example for study, we chose chronic myeloge- nous leukemia because this model is ... See full document
5
Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
... of Bcr-Abl protein highlights a two-lobe catalytic domain: N- and C-lobes towards N- and C-terminus of the sequence, respectively ...the Bcr-Abl ... See full document
15
Targeting BCR-ABL-Independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition
... CP-CML patients, it is associated with considerable cardiovascular toxicity that may be ...of patients taking ponatinib already have or will develop BCR-ABL-independent mechanisms of ... See full document
Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms
... MSCV- BCR/ABL-PAC and MSCV-BCR/ABL-T315I-PAC ...BaF3- Bcr/Abl-T315I cell lines, cells were expanded and frozen; cells were not passaged for more than 6 months after re- ... See full document
5
Update on the management of Philadelphia chromosome positive chronic myelogenous leukemia: role of nilotinib
... Abstract: Chronic myelogenous leukemia (CML) is a pluripotent stem cell disease characterized by the presence of the Philadelphia chromosome and the bcr-abl ...of patients in ... See full document
9
Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib
... of patients receiving 600 mg twice daily: this increase was not accompanied by an increase in levels of amino-transferase or evidence of increased ...of patients and grade 3 elevation of amylase level was ... See full document
5
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR ABL activity
... affecting BCR-ABL similar to those leading to acquired resistance could desensitize BCR-ABL to ...some patients with CCR har- bor imatinib-resistant BCR-ABL kinase domain ... See full document
160
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia
... master regulator [46]. It binds directly near or within 793 genes thereby affecting more than 2300 genes that make up the gene signatures for normal and leukemic stem/pro- genitor cells and myeloid development. ... See full document
61
Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice
... propidium iodide (PI) to allow dead cells to be excluded from both analyses and sorting procedures. Monoclonal antibodies were obtained from Pharmingen and included: Lineage markers (CD45R/B220, for B lineage staining; ... See full document
22
Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy
... of BCR-ABL protein present in these cells ...of BCR- ABL in stem cell antigen 1 (Sca1)-positive cells, the authors generated a murine CML intrinsically resistant to IM ...the ... See full document
23
Masked inv dup(22)(q11.23), tetrasomy 8 and trisomy 19 in a blast crisis-chronic myeloid leukemia after interrupted Imatinib-treatment
... CML-CP patients, in which the complete hematologic re- sponse rate was more than 90 %, and the complete cyto- genetic response rate 70-80 ...of BCR-ABL1 kinase domain, BCR-ABL1 amplifica- tion or ... See full document
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